2.5.1.9: riboflavin synthase

This is an abbreviated version!
For detailed information about riboflavin synthase, go to the full flat file.

Reaction

2 6,7-dimethyl-8-(1-D-ribityl)lumazine =

Synonyms

heavy riboflavin synthase, light riboflavin synthase, lumazine synthase/riboflavin synthase complex, RibD, RibE1, riboflavin synthase, riboflavin synthetase, riboflavine synthase, riboflavine synthetase, synthase, riboflavin

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.9 riboflavin synthase

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Results	in table
14	Activating Compound
18084	AA Sequence
6	Application
1	CAS Registry Number
18	Cloned(Commentary)
1	Cofactor
10	Crystallization (Commentary)
3	Expression
5	General Information
5	General Stability
11	IC50 Value
130	Inhibitors
63	Ki Value [mM]
16	KM Value [mM]
5	Metals/Ions
28	Molecular Weight [Da]
75	Natural Substrates/ Products (Substrates)
268	Organism
1	Oxidation Stability
8	Pathway
93	PDB ID
20	pH Optimum
2	pH Range
4	pH Stability
39	Protein Variants
21	Purification (Commentary)
30	Reaction
1	Reaction Type
88	Reference
14	Source Tissue
38	Specific Activity [micromol/min/mg]
8	Storage Stability
128	Substrates and Products (Substrate)
36	Subunits
17	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
2	Temperature Range [°C]
6	Temperature Stability [°C]
7	Turnover Number [1/s]

General Information

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General Information on EC 2.5.1.9 - riboflavin synthase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

drug target

Brucella abortus

-

the enzyme from Brucella abortus constitutes a suitable target for alternative antibacterial therapy, notably against strains resistant to conventional antibiotic treatments. A high-throughput screening for inhibitors of riboflavin synthase identifies antimicrobial compounds to treat brucellosis

759180

metabolism

Aquifex aeolicus

-

lumazine synthase forms specific inclusion complexes with riboflavin synthase when both proteins are co-expressed in a heterologous host. Encapsulation of specific enzymes in self-assembling protein cages is a hallmark of bacterial compartments that function as counterparts to eukaryotic organelles

759481

physiological function

3 entries

physiological function

Mycobacterium tuberculosis

-

the product of the enzyme, riboflavin (also known as vitamin B2) is the central component of the cofactors FAD and FMN, enzyme plays a key role in energy production, and is required for the metabolism of fats, carbohydrates, and proteins

705302

physiological function

Escherichia coli

P0AFU8

the product of the enzyme, riboflavin (also known as vitamin B2) is the central component of the cofactors FAD and FMN, enzyme plays a key role in energy production, and is required for the metabolism of fats, carbohydrates, and proteins

705302

physiological function

Oryza sativa

-

enzyme overexpression in transgenic tobacco leads to enhanced resistance to tobacco mosaic virus in correlation with enhanced expression of defence response genes

737968