2.5.1.89: tritrans,polycis-undecaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
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For detailed information about tritrans,polycis-undecaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific], go to the full flat file.
Reaction
Synonyms
tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific], undecaprenyl diphosphate synthase, UPPs
ECTree
2.5.1.89 tritrans,polycis-undecaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]Advanced search results
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results (Substrates Products
Substrates Products on EC 2.5.1.89 - tritrans,polycis-undecaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate
8 diphosphate + ditrans,octacis-undecaprenyl diphosphate
about 35% of the activity with geranylgeranyl diphosphate
-
-
?
all-trans-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + hexatrans,tetracis-undecaprenyl diphosphate
geranylgeranyl diphosphate + 7 isopentenyl diphosphate
7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate
-
-
-
?
all-trans-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + hexatrans,tetracis-undecaprenyl diphosphate
-
i.e. (Z,Z,Z,Z,Z,Z,E,E,E,E)-UPP [(2Z,6Z,10Z,14Z,18Z,22Z,26E,30E,34E,38E)-3,7,11,15,19,23,27,31,35,39,43-undecamethyl-2,6,10,14,18,22,26,30,34,38,42-tetratetracontaundecaen-1-yl diphosphate]
-
?
all-trans-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + hexatrans,tetracis-undecaprenyl diphosphate
-
-
-
?
additional information
?
-
the undecaprenyl diphosphate synthase from Aeropyrum pernix that has anomalous substrate specificity, due to the fact that only dimethylallyl diphosphate and geranylfarnesyl diphosphate, both of which are unusual substrates for known cis-prenyltransferases, are likely available as an allylic primer substrate for the archaeal enzyme
-
-
?
additional information
?
-
the enzyme is a cis-prenyltransferas, determination of substrate specificity, product chain-length, and cofactor requirement, overview. The most preferred allylic substrates are farnesyl diphosphate and geranylfarnesyl diphosphate, the main product is UPP, regardless of the substrate. When the ratio of IPP to geranylfarnesyl diphosphate is decreased to 1, the UPP synthase predominately yields shorter C30-45 products. When the ratio is increased to 100, the main product is C60 dodecaprenyl diphosphate. The chain-length of the product of UPP synthase, which determines the structure of the glycosyl carrier lipid, is variable depending on the substrate ratio in the cells of Aeropyrum pernix. A 10fold increase in the substrate ratio results in a significant rise in the production of all-trans-hexaprenyl diphosphate. No activity with dimethylallyl diphosphate. The enzyme also shows the activity of hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific], EC 2.5.1.82, and of geranylgeranyl diphosphate synthase, EC 2.5.1.29
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-
?
additional information
?
-
the undecaprenyl diphosphate synthase from Aeropyrum pernix that has anomalous substrate specificity, due to the fact that only dimethylallyl diphosphate and geranylfarnesyl diphosphate, both of which are unusual substrates for known cis-prenyltransferases, are likely available as an allylic primer substrate for the archaeal enzyme
-
-
?
additional information
?
-
the enzyme is a cis-prenyltransferas, determination of substrate specificity, product chain-length, and cofactor requirement, overview. The most preferred allylic substrates are farnesyl diphosphate and geranylfarnesyl diphosphate, the main product is UPP, regardless of the substrate. When the ratio of IPP to geranylfarnesyl diphosphate is decreased to 1, the UPP synthase predominately yields shorter C30-45 products. When the ratio is increased to 100, the main product is C60 dodecaprenyl diphosphate. The chain-length of the product of UPP synthase, which determines the structure of the glycosyl carrier lipid, is variable depending on the substrate ratio in the cells of Aeropyrum pernix. A 10fold increase in the substrate ratio results in a significant rise in the production of all-trans-hexaprenyl diphosphate. No activity with dimethylallyl diphosphate. The enzyme also shows the activity of hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific], EC 2.5.1.82, and of geranylgeranyl diphosphate synthase, EC 2.5.1.29
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-
?
additional information
?
-
dimethylallyl diphosphate and geranyl diphosphate scarcely react
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-
?
