2.5.1.87: ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]

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For detailed information about ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific], go to the full flat file.

Reaction

Synonyms

AcpT, anther-66, cis-prenyltransferase, cis-PTase, CPT1, Dedol-PP synthase, DedolPP synthase, dehydrodolichyl diphosphate synthase, dehydrodolichyl diphosphate synthase 1, DHDDS, NgBR, Nogo-B receptor, RER2, Rer2p, Rer2p Z-prenyltransferase, SlCPT3, SRT1, Srt1p, Srt2p Z-prenyltransferase, Tk-IdsB

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.87 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]

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Results	in table
2	Activating Compound
3232	AA Sequence
15	Cloned(Commentary)
1	Crystallization (Commentary)
170	Disease/ Diagnostics
5	Expression
23	General Information
2	Inhibitors
13	KM Value [mM]
19	Localization
7	Metals/Ions
6	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
26	Organism
5	Pathway
18	PDB ID
6	pH Optimum
2	pI Value
11	Protein Variants
2	Purification (Commentary)
1	Reaction
24	Reference
16	Source Tissue
2	Storage Stability
30	Substrates and Products (Substrate)
5	Subunits
47	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
2	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 2.5.1.87 - ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]

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SYSTEMATIC NAME

IUBMB Comments

(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 10–55 isopentenyl units)

The enzyme is involved in biosynthesis of dolichol (a long-chain polyprenol) with a saturated alpha-isoprene unit, which serves as a glycosyl carrier in protein glycosylation [1]. The yeast Saccharomyces cerevisiae has two different enzymes that catalyse this reaction. Rer2p synthesizes a well-defined family of polyprenols of 13--18 isoprene residues with dominating C(80) (16 isoprene residues) extending to C(120), while Srt1p synthesizes mainly polyprenol with 22 isoprene subunits. Largest Srt1p products reach C(290) [2]. The enzyme from Arabidopsis thaliana catalyses the formation of polyprenyl diphosphates with predominant carbon number C(120) [4].