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2.5.1.87: ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]

This is an abbreviated version!
For detailed information about ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific], go to the full flat file.

Word Map on EC 2.5.1.87

Reaction

(2E,6E)-farnesyl diphosphate
+ n isopentenyl diphosphate = n diphosphate +
ditrans,polycis-polyprenyl diphosphate (n: 10-55)

Synonyms

AcpT, anther-66, cis-prenyltransferase, cis-PTase, CPT1, Dedol-PP synthase, DedolPP synthase, dehydrodolichyl diphosphate synthase, dehydrodolichyl diphosphate synthase 1, DHDDS, NgBR, Nogo-B receptor, RER2, Rer2p, Rer2p Z-prenyltransferase, SlCPT3, SRT1, Srt1p, Srt2p Z-prenyltransferase, Tk-IdsB

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.87 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]

Natural Substrates Products

Natural Substrates Products on EC 2.5.1.87 - ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + 13 isopentenyl diphosphate
13 diphosphate + di-trans,poly-cis-hexadecaprenyl diphosphate
show the reaction diagram
(2E,6E)-farnesyl diphosphate + 14 isopentenyl diphosphate
14 diphosphate + di-trans,poly-cis-heptadecaprenyl diphosphate
show the reaction diagram
-
di-trans,poly-cis-hexadecaprenyl diphosphate and di-trans,poly-cis-heptadecaprenyl diphosphate are the main products
-
?
(2E,6E)-farnesyl diphosphate + 19 isopentenyl diphosphate
19 diphosphate + di-trans,poly-cis-docosaprenyl diphosphate
show the reaction diagram
-
dominating polyprenol with 22 isoprene residues, Srt1p products reaching C290 indicate the failure of a strict bacterial-like chain length control
-
?
(2E,6E)-farnesyl diphosphate + 21 isopentenyl diphosphate
21 diphosphate + di-trans,poly-cis tetracosaprenyl diphosphate
show the reaction diagram
trans,trans-farnesyl diphosphate is a better substrate than geranylgeranyl diphosphate. The enzyme catalyzes the formation of polyprenyl diphosphates with predominant carbon number C120. In vitro rubber biosynthesis analysis indicates that the Arabidopsis cis-prenyltransferase itself could not catalyze the formation of high molecular weight polyprenyl diphosphate such as natural rubber
-
-
?
(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate
5 diphosphate + di-trans,poly-cis-octaprenyl diphosphate
show the reaction diagram
the polyprenol product of Srt1p is longer in chain length than that of Rer2p and is not sufficiently converted to dolichol and dolichyl phosphate, unlike that of Rer2p
di-trans,poly-cis-octaprenyl diphosphate and di-trans,poly-cis-nonaprenyl diphosphate are the main products
-
?
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate
6 diphosphate + di-trans,poly-cis-nonaprenyl diphosphate
show the reaction diagram
the polyprenol product of Srt1p is longer in chain length than that of Rer2p and is not sufficiently converted to dolichol and dolichyl phosphate, unlike that of Rer2p
di-trans,poly-cis-octaprenyl diphosphate and di-trans,poly-cis-nonaprenyl diphosphate are the main products
-
?
(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate
n diphosphate + di-trans,poly-cis-polyprenyl diphosphate
show the reaction diagram
-
the enzyme preferably utilizes both geranyl diphosphate and farnesyl diphosphate as the starting substrate
-
-
?
(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate
n diphosphate + ditrans,polycis-polyprenyl diphosphate
show the reaction diagram
(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate
n diphosphate + ditrans,polycis-polyprenyl diphosphate (n: 10-55)
show the reaction diagram
geranyl diphosphate + n isopentenyl diphosphate
n diphosphate + di-trans,poly-cis-polyprenyl diphosphate
show the reaction diagram
-
the enzyme preferably utilizes both geranyl diphosphate and farnesyl diphosphate as the starting substrate
-
-
?