2.5.1.81: geranylfarnesyl diphosphate synthase
This is an abbreviated version!
For detailed information about geranylfarnesyl diphosphate synthase, go to the full flat file.
Word Map on EC 2.5.1.81
Reaction
Synonyms
AtIDS1, AtIDS10, AtIDS6, AtIDS7, AtIDS9, C25 farnesylgeranyl diphosphate synthase, C25 FGPP synthase, farnesyl diphosphate synthase, farnesylgeranyl diphosphate synthase, FGPP synthase, Fgs, GFDP synthase, GFDP-forming enzyme, GFDPS, GFPS, IDS3, Lc-GFDPS, MM_0789
ECTree
2.5.1.81 geranylfarnesyl diphosphate synthaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.5.1.81 - geranylfarnesyl diphosphate synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
dimethylallyl diphosphate + 4 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate
farnesyl diphosphate + 2 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
geranyl diphosphate + 3 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
Aeropyrum pernix does not possess geranylgeranyl diphosphate synthase and has only C25-C25 ether lipids, but no C20-containing ether lipids. Aeropyrum pernix farnesylgeranyl diphosphate synthase is important in the biosynthesis of the hydrocarbon moiety of membrane lipids
-
-
?
(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
farnesyl diphosphate is the allylic substrate with the highest activity
-
-
?
(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
-
farnesyl diphosphate shows 93% of the activity with geranylgeranyl diphosphate. Stereochemistry of farnesylgeranyl diphosphate synthesized by FGPP synthase is unclear, but may be an all-E isomer because the same isomer is produced when dimethylallyl diphosphate, geranyl diphosphate, and (all-E)-farnesyl diphosphate, as well as (all-E)-geranylgeranyl diphosphate, are used as substrates. The stereochemistry of the C25 moiety of C20,C25-diether lipids is identical with that of the C20 moiety
-
-
?
dimethylallyl diphosphate + 4 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate
dimethylallyl diphosphate shows 28% of the activity with farnesyl diphosphate
large amounts of intermediates are formed: geranyl diphosphate, farnesyl diphosphate, geranylgeranyl diphosphate
-
?
dimethylallyl diphosphate + 4 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate
-
dimethylallyl diphosphate shows 51% of the activity with farnesyl diphosphate. Stereochemistry of farnesylgeranyl diphosphate synthesized by FGPP synthase is unclear, but may be an all-E isomer because the same isomer is produced when dimethylallyl diphosphate, geranyl diphosphate, and (all-E)-farnesyl diphosphate, as well as (all-E)-geranylgeranyl diphosphate, are used as substrates. The stereochemistry of the C25 moiety of C20,C25-diether lipids is identical with that of the C20 moiety
large amounts of intermediates are formed: geranyl diphosphate, farnesyl diphosphate, geranylgeranyl diphosphate
-
?
farnesyl diphosphate + 2 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis
-
-
?
farnesyl diphosphate + 2 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
the enzyme prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate is the main product, a considerable amount of geranylgeranyl diphosphate as an intermediate is also observed
-
?
geranyl diphosphate + 3 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate
geranyl diphosphate shows 72% of the activity with farnesyl diphosphate
-
-
?
geranyl diphosphate + 3 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate
slight activity
-
-
?
geranyl diphosphate + 3 isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate
-
geranyl diphosphate shows 81% of the activity with farnesyl diphosphate. Stereochemistry of farnesylgeranyl diphosphate synthesized by FGPP synthase is unclear, but may be an all-E isomer because the same isomer is produced when dimethylallyl diphosphate, geranyl diphosphate, and (all-E)-farnesyl diphosphate, as well as (all-E)-geranylgeranyl diphosphate, are used as substrates. The stereochemistry of the C25 moiety of C20,C25-diether lipids is identical with that of the C20 moiety
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
geranylgeranyl diphosphate shows 65% of the activity with farnesyl diphosphate
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
among mutants, in which the bulky residues that constitute the bottom of the product-accommodating cavity is replaced with alanine, those having mutations on an alpha-helix existing at the subunit interface yield longer products
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
the enzyme prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
the enzyme may synthesize a precursor for the C25 moiety of C20,C25 diether lipids
-
-
?
geranylgeranyl diphosphate + isopentenyl diphosphate
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
geranylgeranyl diphosphate is the allylic substrate with the highest activity. Stereochemistry of farnesylgeranyl diphosphate synthesized by FGPP synthase is unclear, but may be an all-E isomer because the same isomer is produced when dimethylallyl diphosphate, geranyl diphosphate, and (all-E)-farnesyl diphosphate, as well as (all-E)-geranylgeranyl diphosphate, are used as substrates. The stereochemistry of the C25 moiety of C20,C25-diether lipids is identical with that of the C20 moiety
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-
?
additional information
?
-
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
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-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29
-
-
?
additional information
?
-
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
the enzyme also shows geranylgeranyl diphosphate synthase activity, EC 2.5.1.29. The GFDP synthase is not part of a heterodimeric geranylgeranyl diphosphate synthase
-
-
?
additional information
?
-
dimethylally diphosphate is not accepted as substrate
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-
?
additional information
?
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-
dimethylally diphosphate is not accepted as substrate
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-
?
additional information
?
-
the residues in chain length determination region III are the predominant factor in the determination of the product specificity
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-
?
additional information
?
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the residues in chain length determination region III are the predominant factor in the determination of the product specificity
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-
?
