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2.5.1.80: 7-dimethylallyltryptophan synthase

This is an abbreviated version!
For detailed information about 7-dimethylallyltryptophan synthase, go to the full flat file.

Word Map on EC 2.5.1.80

Reaction

dimethylallyl diphosphate
+
L-tryptophan
=
diphosphate
 +
7-(3-methylbut-2-enyl)-L-tryptophan

Synonyms

7-dimethylallyl tryptophan synthase, 7-dimethylallyltryptophan synthase, 7-DMATS, 7-DMATSNeo, ANI_1_660114, CAK41583, dimethylallyltryptophan synthase, tryptophan C7-prenyltransferase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.80 7-dimethylallyltryptophan synthase

General Information

General Information on EC 2.5.1.80 - 7-dimethylallyltryptophan synthase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
metabolism
the enzyme is involved in the biosynthesis of astechrome
physiological function
additional information
-
analysis of the structural basis of the regioselective prenylation of L-tryptophan at the C7 position by comparison of the three-dimensional structural models of 7-DMATSNeo with FgaPT2 (4-DMATS), EC 2.5.1.34, from Aspergillus fumigatus. Construction of three-dimensional structural models of 7 DMATSNeo and FgaPT2 (4-DMATS). Docking studies of potential substrates, overview. Residues F129, L130, E138, F226, F243 are involved in binding of L-tryptophan, residue Y393 is involved in stabilization of the allylic cation via cation-Pi interactions. Residues R154, K239, Y241, R311, K313, K391, Y393, K454, and Y460 are involved in diphosphate coordination