2.5.1.73: O-phospho-L-seryl-tRNA:Cys-tRNA synthase
This is an abbreviated version!
For detailed information about O-phospho-L-seryl-tRNA:Cys-tRNA synthase, go to the full flat file.
Word Map on EC 2.5.1.73
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2.5.1.73
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cys-trnacys
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methanogen
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archaea
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o-phosphoseryl-trna
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seprs
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cysteinyl-trna
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o-phosphoserine
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sulfur
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cysrs
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trna-dependent
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cysteinyl-trnacys
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jannaschii
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methanocaldococcus
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selenocysteine
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pyridoxal
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methanosarcina
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sec
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aminoacylation
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misacylated
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acetivorans
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auxotrophy
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persulfide
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relay
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sep-trna:sec-trna
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homocysteine
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fulgidus
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isoacceptors
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aminoacyl-trnas
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archaeoglobus
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trna-bound
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maripaludis
- 2.5.1.73
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cys-trnacys
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methanogen
- archaea
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o-phosphoseryl-trna
- seprs
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cysteinyl-trna
- o-phosphoserine
- sulfur
- cysrs
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trna-dependent
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cysteinyl-trnacys
- jannaschii
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methanocaldococcus
- selenocysteine
- pyridoxal
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methanosarcina
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sec
- aminoacylation
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misacylated
- acetivorans
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auxotrophy
- persulfide
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relay
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sep-trna:sec-trna
- homocysteine
- fulgidus
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isoacceptors
- aminoacyl-trnas
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archaeoglobus
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trna-bound
- maripaludis
Reaction
Synonyms
MJ1678, Sep-tRNA-Cys-tRNA synthase, Sep-tRNA:Cys-tRNA synthase, SepCysS
ECTree
2.5.1.73 O-phospho-L-seryl-tRNA:Cys-tRNA synthaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.5.1.73 - O-phospho-L-seryl-tRNA:Cys-tRNA synthase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
O-phospho-L-seryl-tRNACys + sulfate
L-cysteinyl-tRNACys + phosphate
evolutionary history of Cys-tRNACys formation, overview
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?
O-phospho-L-seryl-tRNACys + sulfate
L-cysteinyl-tRNACys + phosphate
the in vivo sulfur donor is not determined
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?
O-phospho-L-seryl-tRNACys + sulfate
L-cysteinyl-tRNACys + phosphate
evolutionary history of Cys-tRNACys formation, overview
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?
O-phospho-L-seryl-tRNACys + sulfate
L-cysteinyl-tRNACys + phosphate
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evolutionary history of Cys-tRNACys formation, overview
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?
O-phospho-L-seryl-tRNACys + sulfate
L-cysteinyl-tRNACys + phosphate
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evolutionary history of Cys-tRNACys formation, overview
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?
O-phospho-L-seryl-tRNACys + sulfide
L-cysteinyl-tRNACys + phosphate
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the natural sulfur donor is not characterized, the activity of SepCysS provides a means by which both cysteine and selenocysteine can be added to the genetic code, the enzyme is responsible for Cys-tRNACys synthesis together with the O-phosphoseryl-tRNA synthetase in the organism lacking the cysteinyl-tRNACys synthase, EC 6.1.1.16, overview
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?
O-phospho-L-seryl-tRNACys + sulfide
L-cysteinyl-tRNACys + phosphate
Methanocaldococcus jannaschii synthesizes Cys-tRNACys by an indirect pathway, whereby O-phosphoseryltRNA synthetase (SepRS) acylates tRNACys with phosphoserine (Sep), and Sep-tRNACys-tRNA synthase (SepCysS) converts the tRNA-bound phosphoserine to cysteine
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?
O-phospho-L-seryl-tRNACys + sulfide
L-cysteinyl-tRNACys + phosphate
the natural sulfur donor is not characterized, the activity of SepCysS provides a means by which both cysteine and selenocysteine can be added to the genetic code, the enzyme is responsible for Cys-tRNACys synthesis together with the O-phosphoseryl-tRNA synthetase in the organism containing a dispensable cysteinyl-tRNACys synthase, EC 6.1.1.16, overview
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?
O-phospho-L-seryl-tRNACys + sulfide
L-cysteinyl-tRNACys + phosphate
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the sulfur donor for this enzyme is unknown though in vitro sulfide is sufficient. Methanococcus maripaludis encodes both the direct and indirect paths for Cys-tRNACys synthesis. While sepS (encoding SepRS) can be deleted when the organism is grown in the presence of Cys, pscS (encoding SepCysS) cannot. SepCysS may possess an additional function in Methanococcus maripaludis that is essential
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?
additional information
?
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two-step Cys-tRNACys formation: in organisms like Archaeoglobus fulgidus lacking a canonical cysteinyl-tRNA synthetase for the direct Cys-tRNACys formation, Cys-tRNACys is produced by the indirect pathway, in which the non-canonical O-phosphoseryl-tRNA synthetase, SepRS, ligates the non-canonical amino acid O-phosphoserine, Sep, to tRNACys, and the Sep-tRNA:Cys-tRNA synthase converts the produced Sep-tRNACys to Cys-tRNACys, overview, the SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism
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?
additional information
?
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two-step Cys-tRNACys formation: in organisms like Archaeoglobus fulgidus lacking a canonical cysteinyl-tRNA synthetase for the direct Cys-tRNACys formation, Cys-tRNACys is produced by the indirect pathway, in which the non-canonical O-phosphoseryl-tRNA synthetase, SepRS, ligates the non-canonical amino acid O-phosphoserine, Sep, to tRNACys, and the Sep-tRNA:Cys-tRNA synthase converts the produced Sep-tRNACys to Cys-tRNACys, overview, the SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism
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