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2.5.1.73: O-phospho-L-seryl-tRNA:Cys-tRNA synthase

This is an abbreviated version!
For detailed information about O-phospho-L-seryl-tRNA:Cys-tRNA synthase, go to the full flat file.

Word Map on EC 2.5.1.73

Reaction

O-phospho-L-seryl-tRNACys
+
Sulfide
=
L-Cysteinyl-tRNACys
+
phosphate

Synonyms

MJ1678, Sep-tRNA-Cys-tRNA synthase, Sep-tRNA:Cys-tRNA synthase, SepCysS

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.73 O-phospho-L-seryl-tRNA:Cys-tRNA synthase

Activating Compound

Activating Compound on EC 2.5.1.73 - O-phospho-L-seryl-tRNA:Cys-tRNA synthase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
translation factor SepCysE
essential for methanococcal Cys biosynthesis. Its deletion in Methanococcus maripaludiscauses Cys auxotrophy. SepCysE acts as a scaffold for O-phospho-L-serine—tRNA ligase (EC 6.1.1.27) and O-phospho-L-seryl-tRNA:Cys-tRNA synthase to form a stable high-affinity complex for tRNACys causing a 14fold increase in the initial rate of Cys-tRNACys formation
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