2.5.1.72: quinolinate synthase
This is an abbreviated version!
For detailed information about quinolinate synthase, go to the full flat file.
Word Map on EC 2.5.1.72
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2.5.1.72
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nada
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nicotinamide
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dihydroxyacetone
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iminoaspartate
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iron-sulfur
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pyrococcus
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dhap
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horikoshii
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qa
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cluster-containing
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oxygen-sensitive
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desulfurase
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drug development
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synthesis
- 2.5.1.72
-
nada
- nicotinamide
- dihydroxyacetone
- iminoaspartate
-
iron-sulfur
-
pyrococcus
- dhap
- horikoshii
- qa
-
cluster-containing
-
oxygen-sensitive
-
desulfurase
- drug development
- synthesis
Reaction
Synonyms
Fe4S4 quinolinate synthase, NadA, Old5, PfQS, quinolinate synthetase, SufE3, TM_1644
ECTree
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Substrates Products
Substrates Products on EC 2.5.1.72 - quinolinate synthase
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REACTION DIAGRAM
dihydroxyacetone phosphate + iminoaspartate
? + H2O + phosphate
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?
dihydroxyacetone phosphate + iminoaspartate
? + H2O + phosphate
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-
-
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?
pyridine-2,3-dicarboxylate + 2 H2O + phosphate
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-
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?
glycerone phosphate + iminosuccinate
pyridine-2,3-dicarboxylate + 2 H2O + phosphate
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-
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?
glycerone phosphate + iminosuccinate
pyridine-2,3-dicarboxylate + 2 H2O + phosphate
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condensation of dihydroxyacetone phosphate (DHAP) and aspartate-enamine by the action of quinolinate synthase, NadA
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?
glycerone phosphate + iminosuccinate
pyridine-2,3-dicarboxylate + 2 H2O + phosphate
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-
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?
glycerone phosphate + iminosuccinate
pyridine-2,3-dicarboxylate + 2 H2O + phosphate
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
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?
?
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residues C291 and C294 of the C291XXC294XXC297 motif undergo reversible disulfide formation, which regulates the activity of the enzyme
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?
additional information
?
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the enzyme has a triose phosphate isomerase activity catalyzing the reversible isomerization of glycerol 3-phosphate into dihydroxyacetone phosphate in an Fe/S-dependent manner. Only dihydroxyacetone phosphate can then condense with iminoaspartate to form quinolinate. If glycerol 3-phosphate is not converted to dihydroxyacetone phosphate no quinolinate can be produced. The enzyme as triose phosphate isomerase is more efficient in the direction of dihydroxyacetone phosphate production
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-
?
additional information
?
-
the enzyme has a triose phosphate isomerase activity catalyzing the reversible isomerization of glycerol 3-phosphate into dihydroxyacetone phosphate in an Fe/S-dependent manner. Only dihydroxyacetone phosphate can then condense with iminoaspartate to form quinolinate. If glycerol 3-phosphate is not converted to dihydroxyacetone phosphate no quinolinate can be produced. The enzyme as triose phosphate isomerase is more efficient in the direction of dihydroxyacetone phosphate production
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?