2.5.1.68: (2Z,6E)-farnesyl diphosphate synthase
This is an abbreviated version!
For detailed information about (2Z,6E)-farnesyl diphosphate synthase, go to the full flat file.
Word Map on EC 2.5.1.68
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2.5.1.68
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tuberculosis
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synthases
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decaprenyl
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allylic
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lipoarabinomannan
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neryl
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chain-length
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isoprene
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mycolyl-arabinogalactan-peptidoglycan
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cis-prenyltransferase
- 2.5.1.68
- tuberculosis
- synthases
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decaprenyl
-
allylic
- lipoarabinomannan
-
neryl
-
chain-length
- isoprene
-
mycolyl-arabinogalactan-peptidoglycan
- cis-prenyltransferase
Reaction
Synonyms
cis-farnesyl diphosphate synthase, cis-FPS, Mvan 4662, omega,E,Z-FPP, Rv1086, short (C15) chain Z-isoprenyl diphosphate synthase, Z,E-FPP synthase, Z-farnesyl diphosphate synthase, Z-FPP synthase, ZPT1
ECTree
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Inhibitors
Inhibitors on EC 2.5.1.68 - (2Z,6E)-farnesyl diphosphate synthase
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(1-[[(3E)-4,8-dimethylnona-3,7-dien-1-yl](hydroxy)phosphoryl]-1-ethylpropyl)phosphonic acid
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(E)-1-ethyl-1-[(4,8-dimethyl-3,7-nonadienyl)hydroxyphosphoryl] propyl phosphonic acid tripotassium salt
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(E)-geranyl diphosphate analogues
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design and synthesis of substrate analogue inhibitors, overview
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Mn2+
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optimal at 0.1 mM, the enzyme absolutely requires a divalent cation, inhibition by Mn2+ at higher concentration of 5.0 mM
additional information
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no inhibition by dipotassium salt of (E)-1-[(3,7-methyl-2,6-octadienyl)aminocarbonyl] propyl phosphonic acid, dipotassium salt of (E)-1-[[(3,7-methyl-2,6-octadienyl)oxy]aminocarbonyl] propyl phosphonic acid, and dipotassium salt of (E)-2-oxo-2-[(3,7-methyl-2,6-octadienyl)oxy-[amino]ethyl]phosphonic acid
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