2.5.1.68: (2Z,6E)-farnesyl diphosphate synthase
This is an abbreviated version!
For detailed information about (2Z,6E)-farnesyl diphosphate synthase, go to the full flat file.
Word Map on EC 2.5.1.68
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2.5.1.68
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tuberculosis
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synthases
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decaprenyl
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allylic
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lipoarabinomannan
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neryl
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chain-length
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isoprene
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mycolyl-arabinogalactan-peptidoglycan
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cis-prenyltransferase
- 2.5.1.68
- tuberculosis
- synthases
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decaprenyl
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allylic
- lipoarabinomannan
-
neryl
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chain-length
- isoprene
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mycolyl-arabinogalactan-peptidoglycan
- cis-prenyltransferase
Reaction
Synonyms
cis-farnesyl diphosphate synthase, cis-FPS, Mvan 4662, omega,E,Z-FPP, Rv1086, short (C15) chain Z-isoprenyl diphosphate synthase, Z,E-FPP synthase, Z-farnesyl diphosphate synthase, Z-FPP synthase, ZPT1
ECTree
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Engineering
Engineering on EC 2.5.1.68 - (2Z,6E)-farnesyl diphosphate synthase
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L84A
potentially important in limiting chain length. The mutant L84A is not expressed in a soluble form
L84A/L85F
V107G
L84A
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potentially important in limiting chain length. The mutant L84A is not expressed in a soluble form
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L84A/L85F
I59A
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change in product chain-length, produces prenyl products with chain length up to C50
I59M
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change in product chain-length, produces prenyl products with chain length up to C50
I59V
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change in product chain-length, produces prenyl products with chain length up to C50
mutant enzyme has a Km-value for geranyl diphosphate of 0.15 mM compared to 0.038 mM for wild-type Rv108612
L84A/L85F
well expressed and active. Mutant protein is capable of synthesizing prenyl diphosphates containing 20 carbon atoms when geranyl diphosphate is used as the allylic substrate and 50 carbon atoms when EE-farnesyl diphosphate is used as the allylic substrate
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mutant enzyme has a Km-value for geranyl diphosphate of 0.15 mM compared to 0.038 mM for wild-type Rv108612
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L84A/L85F
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well expressed and active. Mutant protein is capable of synthesizing prenyl diphosphates containing 20 carbon atoms when geranyl diphosphate is used as the allylic substrate and 50 carbon atoms when EE-farnesyl diphosphate is used as the allylic substrate
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