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2.5.1.68: (2Z,6E)-farnesyl diphosphate synthase

This is an abbreviated version!
For detailed information about (2Z,6E)-farnesyl diphosphate synthase, go to the full flat file.

Word Map on EC 2.5.1.68

Reaction

geranyl diphosphate
+
isopentenyl diphosphate
=
diphosphate
+
(2Z,6E)-farnesyl diphosphate

Synonyms

cis-farnesyl diphosphate synthase, cis-FPS, Mvan 4662, omega,E,Z-FPP, Rv1086, short (C15) chain Z-isoprenyl diphosphate synthase, Z,E-FPP synthase, Z-farnesyl diphosphate synthase, Z-FPP synthase, ZPT1

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.68 (2Z,6E)-farnesyl diphosphate synthase

Engineering

Engineering on EC 2.5.1.68 - (2Z,6E)-farnesyl diphosphate synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L84A
potentially important in limiting chain length. The mutant L84A is not expressed in a soluble form
L84A/L85F
V107G
L84A
-
potentially important in limiting chain length. The mutant L84A is not expressed in a soluble form
-
L84A/L85F
I59A
-
change in product chain-length, produces prenyl products with chain length up to C50
I59F
-
inactive mutant enzyme
I59M
-
change in product chain-length, produces prenyl products with chain length up to C50
I59V
-
change in product chain-length, produces prenyl products with chain length up to C50