2.5.1.65: O-phosphoserine sulfhydrylase

This is an abbreviated version!
For detailed information about O-phosphoserine sulfhydrylase, go to the full flat file.

Reaction

Synonyms

APE1586, ApOPSS, CysK2, CysM, O-acetyl-L-serine sulfhydrylase, O-acetylserine sulfhydrylase, O-phospho-L-serine sulfhydrylase, O-phospho-L-serine-dependent S-sulfocysteine synthase, O-phosphoserine S-sulfocysteine synthase, O-phosphoserine specific cysteine synthase, O-phosphoserine(thiol)-lyase, OASS, OPSS, Rv1336, S-sulfocysteine synthase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.65 O-phosphoserine sulfhydrylase

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Results	in table
1	Activating Compound
70	AA Sequence
1	CAS Registry Number
11	Cloned(Commentary)
12	Cofactor
8	Crystallization (Commentary)
8	General Information
23	Inhibitors
12	kcat/KM [mM/s]
29	KM Value [mM]
3	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
20	Organism
9	Pathway
30	PDB ID
7	pH Optimum
4	pH Stability
23	Protein Variants
9	Purification (Commentary)
10	Reaction
2	Reaction Type
15	Reference
7	Specific Activity [micromol/min/mg]
1	Storage Stability
59	Substrates and Products (Substrate)
8	Subunits
32	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
3	Temperature Stability [°C]
22	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.5.1.65 - O-phosphoserine sulfhydrylase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

3-chloro-D-alanine

Aeropyrum pernix

-

18% inhibition of the O-acetyl-L-serine sulfhydrylation reaction

655576

3-Cyano-L-alanine

Aeropyrum pernix

-

42% inhibition of the O-acetyl-L-serine sulfhydrylation reaction

655576

Cd2+

Aeropyrum pernix

-

slightly inhibites both O-acetyl-L-serine sulfhydrylation and O-phospho-L-serine sulfhydrylation

655576

CdCl2

Aeropyrum pernix

-

25°C, 10 min, 26% inhibition of the O-phospho-L-serine sulfhydrylation reaction, 15% inhibition of the O-acetyl-L-serine sulfhydrylation reaction

655576

Co2+

Aeropyrum pernix

-

strongly inhibits O-acetyl-L-serine sulfhydrylation, moderately inhibites O-phospho-L-serine sulfhydrylation

655576

CoCl2

Aeropyrum pernix

-

25°C, 10 min, 61% inhibition of the O-phospho-L-serine sulfhydrylation reaction, 98.8% inhibition of the O-acetyl-L-serine sulfhydrylation reaction

655576

Cu2+

Aeropyrum pernix

-

strongly inhibits O-acetyl-L-serine sulfhydrylation, moderately inhibites O-phospho-L-serine sulfhydrylation

655576

CuCl2

Aeropyrum pernix

-

25°C, 10 min, 79% inhibition of the O-phospho-L-serine sulfhydrylation reaction, 98.7% inhibition of the O-acetyl-L-serine sulfhydrylation reaction

655576

Fe2+

Aeropyrum pernix

-

slightly inhibites both O-acetyl-L-serine sulfhydrylation and O-phospho-L-serine sulfhydrylation

655576

Fe3+

Aeropyrum pernix

-

strongly inhibits O-acetyl-L-serine sulfhydrylation, slightly inhibites O-phospho-L-serine sulfhydrylation

655576

FeCl2

Aeropyrum pernix

-

25°C, 10 min, 20% inhibition of the O-phospho-L-serine sulfhydrylation reaction, 27% inhibition of the O-acetyl-L-serine sulfhydrylation reaction

655576

FeCl3

Aeropyrum pernix

-

25°C, 10 min, 25% inhibition of the O-phospho-L-serine sulfhydrylation reaction, 96.1% inhibition of the O-acetyl-L-serine sulfhydrylation reaction

655576

Hg2+

Aeropyrum pernix

-

strongly inhibites both O-acetyl-L-serine sulfhydrylation and O-phospho-L-serine sulfhydrylation

655576

HgCl2

Aeropyrum pernix

-

25°C, 10 min, 98.3% inhibition of the O-phospho-L-serine sulfhydrylation reaction, 80% inhibition of the O-acetyl-L-serine sulfhydrylation reaction

655576

Ni2+

Aeropyrum pernix

-

strongly inhibits O-acetyl-L-serine sulfhydrylation, slightly inhibites O-phospho-L-serine sulfhydrylation

655576

NiCl2

Aeropyrum pernix

-

25°C, 10 min, 15% inhibition of the O-phospho-L-serine sulfhydrylation reaction, almost complete inhibition of the O-acetyl-L-serine sulfhydrylation reaction

655576

O-benzyl-L-serine

Aeropyrum pernix

-

36% inhibition of the O-acetyl-L-serine sulfhydrylation reaction

655576

O-tert-butyl-L-serine

Aeropyrum pernix

-

49% inhibition of the O-acetyl-L-serine sulfhydrylation reaction

655576

Pb(CH3COO)2

Aeropyrum pernix

-

25°C, 10 min, 95% inhibition of the O-phospho-L-serine sulfhydrylation reaction, 88% inhibition of the O-acetyl-L-serine sulfhydrylation reaction

655576

Pb2+

Aeropyrum pernix

-

strongly inhibites both O-acetyl-L-serine sulfhydrylation and O-phospho-L-serine sulfhydrylation

655576

Zn2+

Aeropyrum pernix

-

slightly inhibites both O-acetyl-L-serine sulfhydrylation and O-phospho-L-serine sulfhydrylation

655576

ZnCl2

Aeropyrum pernix

-

25°C, 10 min, 23% inhibition of the O-phospho-L-serine sulfhydrylation reaction, 25% inhibition of the O-acetyl-L-serine sulfhydrylation reaction

655576

additional information

Aeropyrum pernix

-

no inhibition by O-phospho-D-serine, EDTA, 2-mercaptoethanol, DTT, NEM, PCMB, and Gd3+, while Ca2+, K+, Na+, Mn2+, and Mg2+ are poor inhibitors; no inhibition of the O-acetyl-L-serine sulfhydrylation reaction by O-phospho-D-serine

655576

-