2.5.1.59: protein geranylgeranyltransferase type I

This is an abbreviated version!
For detailed information about protein geranylgeranyltransferase type I, go to the full flat file.

Reaction

Synonyms

CAAX geranylgeranyltransferase, CaaX prenyltransferase, CaGGTase-I, CDC43, geranylgeranyl protein transferase type I, geranylgeranyltransferase I, geranylgeranyltransferase type I, geranylgeranyltransferase type-I, geranylgeranyltransferase-1, geranylgeranyltransferase-I, geranylgeranyltransferaseI, GGT, GGT I, GGTalpha, GGTase, GGTase I, Ggtase-1, GGTase-I, GGTaseI, GGTbeta, GGTI, mammalian GGTase-I, PGGT, PGGT beta, PGGT I, PGGT-I, PGGTase-I, PGGTaseI, Ppggb, protein geranylgeranyltransferase, protein geranylgeranyltransferase I, protein geranylgeranyltransferase type I, protein geranylgeranyltransferase type-I, protein geranylgeranyltransferase-I, type I protein geranylgeranyltransferase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.59 protein geranylgeranyltransferase type I

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Results	in table
2	Activating Compound
1401	AA Sequence
7	Application
1	CAS Registry Number
19	Cloned(Commentary)
5	Crystallization (Commentary)
346	Disease/ Diagnostics
32	General Information
41	IC50 Value
117	Inhibitors
4	kcat/KM [mM/s]
14	Ki Value [mM]
28	KM Value [mM]
12	Localization
30	Metals/Ions
14	Molecular Weight [Da]
57	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
73	Organism
150	PDB ID
3	pH Optimum
1	pH Range
1	pH Stability
1	Posttranslational Modification
15	Protein Variants
15	Purification (Commentary)
17	Reaction
73	Reference
58	Source Tissue
3	Specific Activity [micromol/min/mg]
162	Substrates and Products (Substrate)
18	Subunits
105	Synonyms
1	Systematic Name
32	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.5.1.59 - protein geranylgeranyltransferase type I

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SYSTEMATIC NAME

IUBMB Comments

geranylgeranyl-diphosphate:protein-cysteine geranyltransferase

This enzyme, along with protein farnesyltransferase (EC 2.5.1.58) and protein geranylgeranyltransferase type II (EC 2.5.1.60), constitutes the protein prenyltransferase family of enzymes. Catalyses the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. These protein acceptors have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine; serine, methionine, alanine or glutamine makes the protein a substrate for EC 2.5.1.58. The enzymes are relaxed in specificity for A1, but cannot act if A2 is aromatic. Known targets of this enzyme include most gamma-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. A zinc metalloenzyme. The Zn2+ is required for peptide, but not for isoprenoid, substrate binding.