2.5.1.59: protein geranylgeranyltransferase type I
This is an abbreviated version!
For detailed information about protein geranylgeranyltransferase type I, go to the full flat file.
Word Map on EC 2.5.1.59
-
2.5.1.59
-
geranylgeranylation
-
prenylation
-
farnesyltransferase
-
farnesylation
-
ftase
-
isoprenoids
-
prenyltransferases
-
gtpases
-
rhoa
-
peptidomimetic
-
rab
-
mevalonate
-
isoprenylation
-
ggtis
-
h-ras
-
geranylgeraniol
-
farnesylpyrophosphate
-
rap1a
-
lovastatin
-
geranylgeranylpyrophosphate
-
20-carbon
-
escort
-
medicine
-
molecular biology
-
k-ras4b
-
pharmacology
- 2.5.1.59
-
geranylgeranylation
-
prenylation
-
farnesyltransferase
-
farnesylation
- ftase
-
isoprenoids
- prenyltransferases
- gtpases
- rhoa
-
peptidomimetic
- rab
- mevalonate
-
isoprenylation
-
ggtis
- h-ras
- geranylgeraniol
-
farnesylpyrophosphate
- rap1a
- lovastatin
-
geranylgeranylpyrophosphate
-
20-carbon
-
escort
- medicine
- molecular biology
- k-ras4b
- pharmacology
Reaction
Synonyms
CAAX geranylgeranyltransferase, CaaX prenyltransferase, CaGGTase-I, CDC43, geranylgeranyl protein transferase type I, geranylgeranyltransferase I, geranylgeranyltransferase type I, geranylgeranyltransferase type-I, geranylgeranyltransferase-1, geranylgeranyltransferase-I, geranylgeranyltransferaseI, GGT, GGT I, GGTalpha, GGTase, GGTase I, Ggtase-1, GGTase-I, GGTaseI, GGTbeta, GGTI, mammalian GGTase-I, PGGT, PGGT beta, PGGT I, PGGT-I, PGGTase-I, PGGTaseI, Ppggb, protein geranylgeranyltransferase, protein geranylgeranyltransferase I, protein geranylgeranyltransferase type I, protein geranylgeranyltransferase type-I, protein geranylgeranyltransferase-I, type I protein geranylgeranyltransferase
ECTree
2.5.1.59 protein geranylgeranyltransferase type IAdvanced search results
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Reference on EC 2.5.1.59 - protein geranylgeranyltransferase type I
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Casey, P.J.; Seabra, M.C.
Protein prenyltransferases
J. Biol. Chem.
271
5289-5292
1996
Saccharomyces cerevisiae
Yokoyama, K.; Gelb, M.H.
Purification of a mammalian protein geranylgeranyltransferase. Formation and catalytic properties of an enzyme-geranylgeranyl pyrophosphate complex
J. Biol. Chem.
268
4055-4060
1993
Bos taurus
Yokoyama, K.; McGeady, P.; Gelb, M.H.
Mammalian protein geranylgeranyltransferase-I: Substrate specificity, kinetic mechanism, metal requirements, and affinity labeling
Biochemistry
34
1344-1354
1995
Bos taurus
Zhang, F.L.; Moomaw, J.F.; Casey, P.J.
Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I
J. Biol. Chem.
269
23465-23470
1994
Rattus norvegicus
Zhang, F.L.; Casey, P.J.
Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I
Biochem. J.
320
925-932
1996
Rattus norvegicus
-
Zhang, F.L.; Kirschmeier, P.; Carr, D.; James, L.; Bond, R.W.; Wang, L.; Patton, R.; Windsor, W.T.; Syto, R.; Zhang, R.; Bishop, W.R.
Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I
J. Biol. Chem.
272
10232-10239
1997
Homo sapiens
Stirtan, W.G.; Poulter, C.D.
Yeast protein geranylgeranyltransferase type-I: overproduction, purification, and characterization
Arch. Biochem. Biophys.
321
182-190
1995
Saccharomyces cerevisiae
Stirtan, W.G.; Poulter, C.D.
Yeast protein geranylgeranyltransferase type-I: steady-state kinetics and substrate binding
Biochemistry
36
4552-4557
1997
Saccharomyces cerevisiae
Kim, H.; Koo, S.H.; Choi, H.J.; Yang, C.H.
Characterization of yeast geranylgeranyl transferase type I expressed in Escherichia coli
Mol. Cell
6
602-608
1996
Bos taurus, Saccharomyces cerevisiae
-
Kim, H.; Yang, C.H.
Active site determination of yeast geranylgeranyl protein transferase type I expressed in Escherichia coli
Eur. J. Biochem.
265
105-111
1999
Saccharomyces cerevisiae
Ohya, Y.; Caplin, B.E.; Qadota, H.; Tibbetts, M.F.; Anraku, Y.; Pringle, J.R.; Marshall, M.S.
Mutational analysis of the beta-subunit of yeast geranylgeranyl transferase I
Mol. Gen. Genet.
252
1-10
1996
Saccharomyces cerevisiae
Boutin, J.A.; Marande, W.; Goussard, M.; Loynel, A.; Canet, E.; Fauchere, J.L.
Chromatographic assay and peptide substrate characterization of partially purified farnesyl- and geranylgeranyltransferases from rat brain cytosol
Arch. Biochem. Biophys.
354
83-94
1998
Rattus norvegicus
Arellano, M.; Coll, P.M.; Yang, W.; Duran, A.; Tamanol, F.; Perez, P.
Characterization of the geranylgeranyl transferase type I from Schizosaccharomyces pombe
Mol. Microbiol.
29
1357-1367
1998
Schizosaccharomyces pombe
Wilson, A.L.; Erdman, R.A.; Castellano, F.; Maltese, W.A.
Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases
Biochem. J.
333
497-504
1998
Rattus norvegicus
-
Reid, T.S.; Long, S.B.; Beese, L.S.
Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes
Biochemistry
43
9000-9008
2004
Rattus norvegicus
Taylor, J.S.; Reid, T.S.; Terry, K.L.; Casey, P.J.; Beese, L.S.
Structure of mammalian protein geranylgeranyltransferase type-I
EMBO J.
22
5963-5974
2003
Rattus norvegicus
Maurer-Stroh, S.; Washietl, S.; Eisenhaber, F.
Protein prenyltransferases
Genome Biol.
4
212
2003
Homo sapiens
Hartman, H.L.; Bowers, K.E.; Fierke, C.A.
Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium
J. Biol. Chem.
279
30546-30553
2004
Rattus norvegicus
Johnson, C.D.; Chary, S.N.; Chernoff, E.A.; Zeng, Q.; Running, M.P.; Crowell, D.N.
Protein geranylgeranyltransferase I is involved in specific aspects of abscisic acid and auxin signaling in Arabidopsis
Plant Physiol.
139
722-733
2005
Arabidopsis thaliana
Courdavault, V.; Burlat, V.; St-Pierre, B.; Giglioli-Guivarc'h, N.
Characterisation of CaaX-prenyltransferases in Catharanthus roseus: relationships with the expression of genes involved in the early stages of monoterpenoid biosynthetic pathway
Plant Sci.
168
1097-1107
2005
Catharanthus roseus (Q6EMC1), Catharanthus roseus (Q6EZ49)
Hartman, H.L.; Hicks, K.A.; Fierke, C.A.
Peptide specificity of protein prenyltransferases is determined mainly by reactivity rather than binding affinity
Biochemistry
44
15314-15324
2005
Escherichia coli
Hicks, K.A.; Hartman, H.L.; Fierke, C.A.
Upstream polybasic region in peptides enhances dual specificity for prenylation by both farnesyltransferase and geranylgeranyltransferase type I
Biochemistry
44
15325-15333
2005
Escherichia coli
Terry, K.L.; Casey, P.J.; Beese, L.S.
Conversion of protein farnesyltransferase to a geranylgeranyltransferase
Biochemistry
45
9746-9755
2006
Homo sapiens
Carrico, D.; Blaskovich, M.A.; Bucher, C.J.; Sebti, S.M.; Hamilton, A.D.
Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I
Bioorg. Med. Chem.
13
677-688
2005
Homo sapiens
Epifano, F.; Curini, M.; Genovese, S.; Blaskovich, M.; Hamilton, A.; Sebti, S.M.
Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I
Bioorg. Med. Chem. Lett.
17
2639-2642
2007
Homo sapiens
Dursina, B.; Reents, R.; Delon, C.; Wu, Y.; Kulharia, M.; Thutewohl, M.; Veligodsky, A.; Kalinin, A.; Evstifeev, V.; Ciobanu, D.; Szedlacsek, S.E.; Waldmann, H.; Goody, R.S.; Alexandrov, K.
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids
J. Am. Chem. Soc.
128
2822-2835
2006
Homo sapiens
Castellano, S.; Fiji, H.D.; Kinderman, S.S.; Watanabe, M.; de Leon, P.; Tamanoi, F.; Kwon, O.
Small-molecule inhibitors of protein geranylgeranyltransferase type I
J. Am. Chem. Soc.
129
5843-5845
2007
Homo sapiens
Philips, M.R.; Cox, A.D.
Geranylgeranyltransferase I as a target for anti-cancer drugs
J. Clin. Invest.
117
1223-1225
2007
Mus musculus
Lane, K.T.; Beese, L.S.
Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I
J. Lipid Res.
47
681-699
2006
Rattus norvegicus
Machida, S.; Usuba, K.; Blaskovich, M.A.; Yano, A.; Harada, K.; Sebti, S.M.; Kato, N.; Ohkanda, J.
Module assembly for protein-surface recognition: geranylgeranyltransferase I bivalent inhibitors for simultaneous targeting of interior and exterior protein surfaces
Chemistry
14
1392-1401
2008
Homo sapiens, Rattus norvegicus
Hast, M.A.; Beese, L.S.
Structure of protein geranylgeranyltransferase-I from the human pathogen Candida albicans complexed with a lipid substrate
J. Biol. Chem.
283
31933-31940
2008
Candida albicans (Q9Y765), Candida albicans
Watanabe, M.; Fiji, H.D.; Guo, L.; Chan, L.; Kinderman, S.S.; Slamon, D.J.; Kwon, O.; Tamanoi, F.
Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds
J. Biol. Chem.
283
9571-9579
2008
Rattus norvegicus
Yokoyama, K.; Gillespie, J.R.; Van Voorhis, W.C.; Buckner, F.S.; Gelb, M.H.
Protein geranylgeranyltransferase-I of Trypanosoma cruzi
Mol. Biochem. Parasitol.
157
32-43
2008
Trypanosoma cruzi (A7Y1U8), Trypanosoma cruzi
Courdavault, V.; Burlat, V.; St-Pierre, B.; Giglioli-Guivarch, N.
Proteins prenylated by type I protein geranylgeranyltransferase act positively on the jasmonate signalling pathway triggering the biosynthesis of monoterpene indole alkaloids in Catharanthus roseus
Plant Cell Rep.
28
83-93
2009
Catharanthus roseus
Suzuki, T.; Ito, M.; Ezure, T.; Shikata, M.; Ando, E.; Utsumi, T.; Tsunasawa, S.; Nishimura, O.
Protein prenylation in an insect cell-free protein synthesis system and identification of products by mass spectrometry
Proteomics
7
1942-1950
2007
Homo sapiens
Peterson, Y.K.; Wang, X.S.; Casey, P.J.; Tropsha, A.
Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation
J. Med. Chem.
52
4210-4220
2009
Mammalia, Rattus norvegicus
Chen, S.; Fu, L.; Raja, S.M.; Yue, P.; Khuri, F.R.; Sun, S.Y.
Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis
Mol. Cancer
9
23
2010
Homo sapiens
Rao, P.V.; Peterson, Y.K.; Inoue, T.; Casey, P.J.
Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork
Invest. Ophthalmol. Vis. Sci.
49
2464-2471
2008
Homo sapiens, Sus scrofa
Ghavami, S.; Mutawe, M.; Schaafsma, D.; Yeganeh, B.; Unruh, H.; Klonisch, T.; Halayko, A.
Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle
Am. J. Physiol. Lung Cell Mol. Physiol.
302
L420-L428
2012
Homo sapiens
Qiao, Y.; Gao, J.; Qiu, Y.; Wu, L.; Guo, F.; Lo, K.K.; Li, D.
Design, synthesis, and characterization of piperazinedione-based dual protein inhibitors for both farnesyltransferase and geranylgeranyltransferase-I
Eur. J. Med. Chem.
46
2264-2273
2011
Rattus norvegicus
Zhou, X.; Qian, J.; Hua, L.; Shi, Q.; Liu, Z.; Xu, Y.; Sang, B.; Mo, J.; Yu, R.
Geranylgeranyltransferase I promotes human glioma cell growth through Rac1 membrane association and activation
J. Mol. Neurosci.
49
130-139
2013
Homo sapiens
Wu, K.; Zhou, X.; Luo, Z.
Geranylgeranyltransferase I is essential for dendritic development of cerebellar Purkinje cells
Mol. Brain
3
18
2010
Rattus norvegicus
Gangopadhyay, S.A.; Losito, E.L.; Hougland, J.L.
Targeted reengineering of protein geranylgeranyltransferase type I selectivity functionally implicates active-site residues in protein-substrate recognition
Biochemistry
53
434-446
2014
Rattus norvegicus (P53610), Rattus norvegicus (Q04631)
Shen, M.; Pan, P.; Li, Y.; Li, D.; Yu, H.; Hou, T.
Farnesyltransferase and geranylgeranyltransferase I: structures, mechanism, inhibitors and molecular modeling
Drug Discov. Today
20
267-276
2015
Homo sapiens (P49354), Homo sapiens (P53609), Rattus norvegicus (P53610), Rattus norvegicus (Q04631)
Selvig, K.; Ballou, E.R.; Nichols, C.B.; Alspaugh, J.A.
Restricted substrate specificity for the geranylgeranyltransferase-I enzyme in Cryptococcus neoformans: implications for virulence
Eukaryot. Cell
12
1462-1471
2013
Cryptococcus neoformans (J9VNV2), Cryptococcus neoformans
Li, Z.; Sun, C.; Zhang, T.; Mo, J.; Shi, Q.; Zhang, X.; Yuan, M.; Chen, L.; Mao, X.; Yu, R.; Zhou, X.
Geranylgeranyltransferase I mediates BDNF-induced synaptogenesis
J. Neurochem.
125
698-712
2013
Rattus norvegicus (P53610), Rattus norvegicus (Q04631), Rattus norvegicus Sprague-Dawley (P53610), Rattus norvegicus Sprague-Dawley (Q04631)
Gao, S.; Yu, R.; Zhou, X.
The role of geranylgeranyltransferase I-mediated protein prenylation in the brain
Mol. Neurobiol.
53
6925-6937
2015
Homo sapiens (P49354), Homo sapiens (P53609), Rattus norvegicus (P53610), Rattus norvegicus (Q04631), Mus musculus (Q61239), Mus musculus (Q8BUY9)
Thole, J.M.; Perroud, P.F.; Quatrano, R.S.; Running, M.P.
Prenylation is required for polar cell elongation, cell adhesion, and differentiation in Physcomitrella patens
Plant J.
78
441-451
2014
Physcomitrium patens
Lu, J.; Yoshimura, K.; Goto, K.; Lee, C.; Hamura, K.; Kwon, O.; Tamanoi, F.
Nanoformulation of geranylgeranyltransferase-I inhibitors for cancer therapy: liposomal encapsulation and pH-dependent delivery to cancer cells
PLoS ONE
10
e0137595
2015
Homo sapiens (P49354), Homo sapiens (P53609), Homo sapiens
Sun, Q.; Xiong, K.; Yuan, Y.; Yu, J.; Yang, L.; Shen, C.; Su, C.; Lu, Y.
Inhibiting fungal echinocandin resistance by small-molecule disruption of geranylgeranyltransferase type i activity
Antimicrob. Agents Chemother.
64
e02046-19
2020
[Candida] glabrata, Candida parapsilosis, Candida tropicalis, Candida albicans (Q9Y764), Candida albicans
Ashok, S.; Hildebrandt, E.R.; Ruiz, C.S.; Hardgrove, D.S.; Coreno, D.W.; Schmidt, W.K.; Hougland, J.L.
Protein farnesyltransferase catalyzes unanticipated farnesylation and geranylgeranylation of shortened target sequences
Biochemistry
59
1149-1162
2020
Rattus norvegicus (Q04631 AND Q02293)
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