2.5.1.59: protein geranylgeranyltransferase type I
This is an abbreviated version!
For detailed information about protein geranylgeranyltransferase type I, go to the full flat file.
Word Map on EC 2.5.1.59
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2.5.1.59
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geranylgeranylation
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prenylation
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farnesyltransferase
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farnesylation
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ftase
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isoprenoids
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prenyltransferases
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gtpases
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rhoa
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peptidomimetic
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rab
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mevalonate
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isoprenylation
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ggtis
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h-ras
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geranylgeraniol
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farnesylpyrophosphate
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rap1a
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lovastatin
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geranylgeranylpyrophosphate
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20-carbon
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escort
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medicine
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molecular biology
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k-ras4b
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pharmacology
- 2.5.1.59
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geranylgeranylation
-
prenylation
-
farnesyltransferase
-
farnesylation
- ftase
-
isoprenoids
- prenyltransferases
- gtpases
- rhoa
-
peptidomimetic
- rab
- mevalonate
-
isoprenylation
-
ggtis
- h-ras
- geranylgeraniol
-
farnesylpyrophosphate
- rap1a
- lovastatin
-
geranylgeranylpyrophosphate
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20-carbon
-
escort
- medicine
- molecular biology
- k-ras4b
- pharmacology
Reaction
Synonyms
CAAX geranylgeranyltransferase, CaaX prenyltransferase, CaGGTase-I, CDC43, geranylgeranyl protein transferase type I, geranylgeranyltransferase I, geranylgeranyltransferase type I, geranylgeranyltransferase type-I, geranylgeranyltransferase-1, geranylgeranyltransferase-I, geranylgeranyltransferaseI, GGT, GGT I, GGTalpha, GGTase, GGTase I, Ggtase-1, GGTase-I, GGTaseI, GGTbeta, GGTI, mammalian GGTase-I, PGGT, PGGT beta, PGGT I, PGGT-I, PGGTase-I, PGGTaseI, Ppggb, protein geranylgeranyltransferase, protein geranylgeranyltransferase I, protein geranylgeranyltransferase type I, protein geranylgeranyltransferase type-I, protein geranylgeranyltransferase-I, type I protein geranylgeranyltransferase
ECTree
2.5.1.59 protein geranylgeranyltransferase type IAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 2.5.1.59 - protein geranylgeranyltransferase type I
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
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the enzyme catalyzes postttranslational modification of proteins, the farnesyl moieties attached to the substrates are direcly involved in protein-protein interactions as well as in protein-membrane interactions
-
-
?
geranylgeranyl diphosphate + Cdc420-cysteine
S-geranylgeranyl-Cdc420 + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl protein + diphosphate
-
the enzyme catalyzes posttranslational modification of proteins, the farnesyl moieties attached to the substrates are direcly involved in protein-protein interactions as well as in protein-membrane interactions
-
-
?
geranylgeranyl diphosphate + Rac GTPase-cysteine
S-geranylgeranyl-Rac GTPase + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Ras-CVLL
S-geranylgeranyl-Ras-CVLL + diphosphate
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tritium labelled geranylgeranyl diphosphate for enzyme assay, His-tagged geranylgeranyl diphosphate
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-
?
geranylgeranyl diphosphate + Rho GTPase-cysteine
S-geranylgeranyl-Rho GTPase + diphosphate
geranylgeranyl diphosphate + Rho10-cysteine
S-geranylgeranyl-Rho10 + diphosphate
-
-
-
?
geranylgeranyl diphosphate + RhoA GTPase-cysteine
S-geranylgeranyl-RhoA GTPase + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Cdc42-cysteine
S-geranylgeranyl-Cdc42 + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Cdc42-cysteine
S-geranylgeranyl-Cdc42 + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Cdc42-cysteine
S-geranylgeranyl-Cdc42 + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Cdc42-cysteine
S-geranylgeranyl-Cdc42 + diphosphate
-
-
-
?
geranylgeranyl diphosphate + K Ras-cysteine
S-geranylgeranyl-K Ras + diphosphate
-
-
-
?
geranylgeranyl diphosphate + K Ras-cysteine
S-geranylgeranyl-K Ras + diphosphate
-
-
-
?
geranylgeranyl diphosphate + N-Ras-cysteine
S-geranylgeranyl-N-Ras + diphosphate
-
-
-
?
geranylgeranyl diphosphate + N-Ras-cysteine
S-geranylgeranyl-N-Ras + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
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the enzyme negatively regulates abscisic acid signaling in guard cells. The enzyme is specifically involved in negative regulation of auxin-induced lateral root initiation
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-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
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enzyme catalyses the transfer of the 20-carbon prenyl group from geranylgeranyl diphosphate to the cysteine residue near the C-termini of a variety of eukaryotic proteins
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-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
the enzyme adds a C20 geranylgeranyl group to proteins such as RhoA, RhoC, Rap1 and Ral at the cysteine within the carboxy-terminal tetrapeptide consensus sequence CAAL (C is cysteine, A is an aliphatic amino acid, and the C-terminal residue is leucine or phenylalanine)
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
GGTase-I catalyzes C-terminal lipidation of more than 100 proteins, including many GTP-binding regulatory proteins
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
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this prenylation is necessary for many proteins to interact with membrane localized at proper intracellular sites
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
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yeast enzyme is essential for yeast cell growth
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-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
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this prenylation is necessary for many proteins to interact with membrane localized at proper intracellular sites
-
-
?
geranylgeranyl diphosphate + Rac-cysteine
S-geranylgeranyl-Rac + diphosphate
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-
-
?
geranylgeranyl diphosphate + Rac-cysteine
S-geranylgeranyl-Rac + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Rac-cysteine
S-geranylgeranyl-Rac + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Rac-cysteine
S-geranylgeranyl-Rac + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Rap-cysteine
S-geranylgeranyl-Rap + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Rap-cysteine
S-geranylgeranyl-Rap + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Rap1A-cysteine
S-geranylgeranyl-Rap1A + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Rap1A-cysteine
S-geranylgeranyl-Rap1A + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Rap1A-cysteine
S-geranylgeranyl-Rap1A + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Rap1A-cysteine
S-geranylgeranyl-Rap1A + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Ras protein
S-geranylgeranyl-Ras protein + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + Ras protein
S-geranylgeranyl-Ras protein + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + Rho GTPase-cysteine
S-geranylgeranyl-Rho GTPase + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Rho GTPase-cysteine
S-geranylgeranyl-Rho GTPase + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Rho-cysteine
S-geranylgeranyl-Rho + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Rho-cysteine
S-geranylgeranyl-Rho + diphosphate
-
-
-
?
additional information
?
-
the enzyme modifies proteins by attaching a 20-carbon isoprenoid group to a cysteine residue near the C-terminus of a target protein. The enzyme requires a C-terminal Ca1a2X sequence on its substrates, with the a1, a2, and X residues serving as substrate-recognition elements for GGTase-I. Crystallographic structures of rat GGTase-I show a tightly packed and hydrophobic a2 residue binding pocket, consistent with a preference for moderately sized a2 residues in GGTase-I substrates, peptide substrate structure-activity relationship, overview. Identification of specific active-site residues within rat GGTase-I involved in substrate recognition
-
-
?
additional information
?
-
the enzyme modifies proteins by attaching a 20-carbon isoprenoid group to a cysteine residue near the C-terminus of a target protein. The enzyme requires a C-terminal Ca1a2X sequence on its substrates, with the a1, a2, and X residues serving as substrate-recognition elements for GGTase-I. Crystallographic structures of rat GGTase-I show a tightly packed and hydrophobic a2 residue binding pocket, consistent with a preference for moderately sized a2 residues in GGTase-I substrates, peptide substrate structure-activity relationship, overview. Identification of specific active-site residues within rat GGTase-I involved in substrate recognition
-
-
?
