2.5.1.59: protein geranylgeranyltransferase type I

This is an abbreviated version!
For detailed information about protein geranylgeranyltransferase type I, go to the full flat file.

Word Map on EC 2.5.1.59

2.5.1.59

geranylgeranylation

prenylation

farnesyltransferase

farnesylation

ftase

isoprenoids

prenyltransferases

gtpases

rhoa

peptidomimetic

rab

mevalonate

isoprenylation

ggtis

h-ras

geranylgeraniol

farnesylpyrophosphate

rap1a

lovastatin

geranylgeranylpyrophosphate

20-carbon

escort

medicine

molecular biology

k-ras4b

pharmacology

Reaction

Synonyms

CAAX geranylgeranyltransferase, CaaX prenyltransferase, CaGGTase-I, CDC43, geranylgeranyl protein transferase type I, geranylgeranyltransferase I, geranylgeranyltransferase type I, geranylgeranyltransferase type-I, geranylgeranyltransferase-1, geranylgeranyltransferase-I, geranylgeranyltransferaseI, GGT, GGT I, GGTalpha, GGTase, GGTase I, Ggtase-1, GGTase-I, GGTaseI, GGTbeta, GGTI, mammalian GGTase-I, PGGT, PGGT beta, PGGT I, PGGT-I, PGGTase-I, PGGTaseI, Ppggb, protein geranylgeranyltransferase, protein geranylgeranyltransferase I, protein geranylgeranyltransferase type I, protein geranylgeranyltransferase type-I, protein geranylgeranyltransferase-I, type I protein geranylgeranyltransferase

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.59 protein geranylgeranyltransferase type I

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Results	in table
2	Activating Compound
1401	AA Sequence
7	Application
1	CAS Registry Number
19	Cloned(Commentary)
5	Crystallization (Commentary)
346	Disease/ Diagnostics
32	General Information
41	IC50 Value
117	Inhibitors
4	kcat/KM [mM/s]
14	Ki Value [mM]
28	KM Value [mM]
12	Localization
30	Metals/Ions
14	Molecular Weight [Da]
57	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
73	Organism
150	PDB ID
3	pH Optimum
1	pH Range
1	pH Stability
1	Posttranslational Modification
15	Protein Variants
15	Purification (Commentary)
17	Reaction
73	Reference
58	Source Tissue
3	Specific Activity [micromol/min/mg]
162	Substrates and Products (Substrate)
18	Subunits
105	Synonyms
1	Systematic Name
32	Turnover Number [1/s]

KM Value

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KM Value on EC 2.5.1.59 - protein geranylgeranyltransferase type I

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0.00027 - 0.025

(biotin-CONH-(CH2)5-CO-)-NPFREKKFFCAI-Leu

3 entries

0.00003

3,7,11-trimethyl-12-(7-nitro-benzo[1,2,5]-oxadiazo-4-ylamino)-dodeca-2,6,10-trien-1-diphosphate

Homo sapiens

674196

0.00002

Arg-Arg-Cys-Val-Leu-Leu

Rattus norvegicus

pH 7.6, 30°C

636548

0.00000133

Asp-Asp-Pro-Thr-Ala-Ser-Ala-Cys-Val-Leu-Leu

Homo sapiens

at 30°C

672214

0.0018 - 0.0024

dansyl-Gly-Cys-Ile-Ile-Leu

2 entries

0.000003 - 0.001

geranylgeranyl diphosphate

5 entries

0.016

GST-CDC42

Bos taurus

pH 7.0, 30°C, prenyl donor: geranylgeranyl diphosphate

636539

0.042

GST-RhoA

Homo sapiens

674196

0.0088

Ki-Ras4A

Homo sapiens

pH 7.5, 37°C

636542

0.012

Ki-Ras4B

Homo sapiens

pH 7.5, 37°C

636542

0.00013

Lys-Lys-Cys-Ile-Ile-Met

Rattus norvegicus

pH 7.6, 30°C

636548

0.002

Lys-Pro-Cys-Val-Val-Met

Rattus norvegicus

pH 7.6, 30°C

636548

0.0021

N-Ras

Homo sapiens

pH 7.5, 37°C

636542

0.002

Phe-Phe-Cys-Ala-Ile-Leu

Rattus norvegicus

pH 7.6, 30°C

636548

0.0009 - 0.0012

Ras-Cys-Val-Leu-Leu

2 entries

0.0002

Ser-Ser-Cys-Ile-Leu-Leu

Bos taurus

pH 7.4, 30°C

636538

0.00143

[glutathione S-transferase]-GCVKIKKCVIL

Saccharomyces cerevisiae

pH 7.5, 37°C

636545

additional information

3 entries