2.5.1.58: protein farnesyltransferase
This is an abbreviated version!
For detailed information about protein farnesyltransferase, go to the full flat file.
Word Map on EC 2.5.1.58
-
2.5.1.58
-
farnesylation
-
prenylation
-
geranylgeranylation
-
isoprenoids
-
beta-subunits
-
isoprenylation
-
15-carbon
-
lamins
-
manumycin
-
geranylgeranyltransferase-i
-
farnesyl-protein
-
h-ras
-
medicine
-
peptidomimetic
-
prelamin
-
ggtase-i
-
p21ras
-
tetrapeptide
-
farnesol
-
tetrahydroquinoline
-
ras-dependent
-
pharmacology
-
progerin
-
3hmevalonate
-
ras-induced
-
lovastatin
-
tipifarnib
-
drug development
-
ras-mediated
-
ras-transformed
-
lonafarnib
-
hutchinson-gilford
-
dimethylallyl
-
geranylgeraniol
-
isoprene
-
analysis
- 2.5.1.58
-
farnesylation
-
prenylation
-
geranylgeranylation
-
isoprenoids
- beta-subunits
-
isoprenylation
-
15-carbon
- lamins
- manumycin
-
geranylgeranyltransferase-i
-
farnesyl-protein
- h-ras
- medicine
-
peptidomimetic
-
prelamin
- ggtase-i
-
p21ras
- tetrapeptide
- farnesol
- tetrahydroquinoline
-
ras-dependent
- pharmacology
-
progerin
-
3hmevalonate
-
ras-induced
- lovastatin
- tipifarnib
- drug development
-
ras-mediated
-
ras-transformed
- lonafarnib
-
hutchinson-gilford
-
dimethylallyl
- geranylgeraniol
- isoprene
- analysis
Reaction
Synonyms
AfFTase, CAAX farnesyltransferase, EhFT, Era1, farnesyl protein transferase, farnesyltransferase, farnesyltransferase ternary complex part II, farnesyltransferase, farnesyl pyrophosphate-protein, farnesyltransferase, protein, FntA, FntB, FPT, fptase, FTase, hFTase, HIT5, Pf-PFT, PfPFT, PFT, PFTase, prenyl transferase, prenylprotein transferase, prenyltransferase, protein cysteine farnesyltransferase, protein farnesyl transferase, protein farnesyltransferase, protein prenyltransferase, protein-farnesyltransferase, R-PFT, Ram1, RAS farnesyltransferase, Ras protein farnesyltransferase, rFPTase, rFTase, rPFTase, TbFTase, yPFTase
ECTree
2.5.1.58 protein farnesyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.5.1.58 - protein farnesyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(1E)-1-[(2E,6E,10E)-12-azido-3,7,11-trimethyldodeca-2,6,10-trien-1-ylidene]-2-oxodiphosphane + protein-cysteine
?
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-(2,3,5,6-tetrafluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(2,3,5,6-tetrafluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-(phenylamino)octa-2,6-dien-1-yl diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-(phenylamino)octa-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-(phenylsulfanyl)octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-(phenylsulfanyl)octa-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CCIQ
?
-
-
-
?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CGGDD
?
-
-
-
?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CSVL
?
-
-
-
?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CTIQ
?
-
-
-
?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CVIS
?
-
-
-
?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CVLL
?
-
-
-
?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CVLS
?
-
-
-
?
(2E,6E)-3,7-dimethyl-8-phenoxyocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-phenoxyocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-[(2-methylphenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[(2-methylphenyl)amino]octa-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-[(3,4,5-trimethoxybenzyl)oxy]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[(3,4,5-trimethoxybenzyl)oxy]octa-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-[(3-methylphenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[(3-methylphenyl)amino]octa-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-[(4-methylphenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[(4-methylphenyl)amino]octa-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-[(4-nitrophenyl)amino]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[(4-nitrophenyl)amino]octa-2,6-dien-1-y)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-[3-(1-methylethyl)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[3-(1-methylethyl)phenoxy]octa-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-[3-(trifluoromethoxy)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[3-(trifluoromethoxy)phenoxy]octa-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-[3-(trifluoromethyl)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[3-(trifluoromethyl)phenoxy]octa-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-[4-(1-methylethyl)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[4-(1-methylethyl)phenoxy]octa-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-[4-(trifluoromethoxy)phenoxy]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[4-(trifluoromethoxy)phenoxy]octa-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-[[2-(trifluoromethyl)phenyl]amino]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[[2-(trifluoromethyl)phenyl]amino]octa-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-[[3-(trifluoromethoxy)phenyl]amino]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[[3-(trifluoromethoxy)phenyl]amino]octa-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-8-[[4-(trifluoromethoxy)phenyl]amino]octa-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-8-[[4-(trifluoromethoxy)phenyl]amino]octa-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-3,7-dimethyl-9-phenylnona-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-3,7-dimethyl-9-phenylnona-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(2,3-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(2,3-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(2,6-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(2,6-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(2-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(2-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(2-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(2-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(2-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(2-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yll)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(2-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(2-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(3,4-dichlorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3,4-dichlorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(3,4-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3,4-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(3,5-dichlorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3,5-dichlorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(3,5-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3,5-difluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(3-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(3-cyanophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3-cyanophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(3-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(3-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yll)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(3-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(3-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(4-benzylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(4-benzylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(4-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(4-bromophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(4-cyanophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(4-cyanophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(4-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(4-ethylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(4-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(4-fluorophenoxy)-3,7-dimethylocta-2,6-dien-1-yll)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(4-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(4-iodophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(4-nitrophenoxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(4-nitrophenoxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(benzyloxy)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(benzyloxy)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-(isoxazol-3-ylamino)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-(isoxazol-3-ylamino)-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-[(2-ethylphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(2-ethylphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-[(2-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(2-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-[(2-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(2-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-[(3-bromophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(3-bromophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-[(3-cyanophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(3-cyanophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-[(3-ethylphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(3-ethylphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-[(3-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(3-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-[(3-iodophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(3-iodophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-[(3-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(3-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-[(4-bromophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(4-bromophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-[(4-cyanophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(4-cyanophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-[(4-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(4-fluorophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-[(4-iodophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(4-iodophenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-[(4-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[(4-methoxyphenyl)amino]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-[3-(hydroxymethyl)phenoxy]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[3-(hydroxymethyl)phenoxy]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-8-[4-(hydroxymethyl)phenoxy]-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-8-[4-(hydroxymethyl)phenoxy]-3,7-dimethylocta-2,6-dien-1-yl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine
S-(2E,6E)-farnesyl protein + diphosphate
(2E,6E)-farnesyl diphosphate + CCIQ
S-(2E,6E)-farnesyl-CCIQ + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + CGGDD
S-(2E,6E)-farnesyl-CGGDD + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + CSVL
S-(2E,6E)-farnesyl-CSVL + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + CTIQ
S-(2E,6E)-farnesyl-CTIQ + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + CVIS
S-(2E,6E)-farnesyl-CVIS + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + CVLL
S-(2E,6E)-farnesyl-CVLL + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + CVLS
S-(2E,6E)-farnesyl-CVLS + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + dansyl-CGVLS
dansyl-G-(S-(2E,6E)-farnesyl)CVLS
-
assay at pH 7.5, 37°C
-
-
?
(2E,6E)-farnesyl diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-farnesyl)CVLS + diphosphate
(2E,6E)-farnesyl diphosphate + K Ras-cysteine
S-(2E,6E)-farnesyl-[K Ras]-L-cysteine + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + KGCVIM
S-(2E,6E)-farnesyl-KGCVIM + diphosphate
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + KGCVVM
S-(2E,6E)-farnesyl-KGCVVM + diphosphate
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + [H Ras]-L-cysteine
S-(2E,6E)-farnesyl-[H Ras]-L-cysteine + diphosphate
(2E,6E)-farnesyl diphosphate + [K Ras]-L-cysteine
S-(2E,6E)-farnesyl-[K Ras]-L-cysteine + diphosphate
(2E,6E)-farnesyl diphosphate + [N Ras]-L-cysteine
S-(2E,6E)-farnesyl-[N Ras]-L-cysteine + diphosphate
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
[protein]-S-((2E,6E)-farnesyl)-L-cysteine + diphosphate
-
assay at pH 7.5, 30°C
-
-
?
(2E,6E)-farnesyl diphosphate + [Rho]-L-cysteine
S-(2E,6E)-farnesyl-[Rho]-L-cysteine + diphosphate
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CCIQ
?
-
-
-
?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CGGDD
?
-
-
-
?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CSVL
?
-
-
-
?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CTIQ
?
-
-
-
?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CVIS
?
-
-
-
?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CVLL
?
-
-
-
?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CVLS
?
-
-
-
?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CCIQ
?
-
-
-
?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CGGDD
?
-
-
-
?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CSVL
?
-
-
-
?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CTIQ
?
-
-
-
?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CVIS
?
-
-
-
?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CVLL
?
-
-
-
?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CVLS
?
-
-
-
?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CCIQ
?
-
-
-
?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CGGDD
?
-
-
-
?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CSVL
?
-
-
-
?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CTIQ
?
-
-
-
?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CVIS
?
-
-
-
?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CVLL
?
-
-
-
?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CVLS
?
-
-
-
?
(2Z)-geranylgeranyl diphosphate + protein cysteine
diphosphate + S-(2Z)-geranylgeranylcysteinyl protein
-
-
-
-
?
10-benzyloxy-3-methyl-2-decen-1-ol-diphosphate + N-dansyl-Gly-Cys-Val-Leu-Ser
diphosphate + N-dansyl-Gly-S-(10-benzyloxy-3-methyl-2-decenyl)-Cys-Val-Leu-Ser
-
-
-
-
?
12-propargoxyfarnesyl diphosphate + N-dansyl-Gly-Cys-Val-Ile-Ala-OH
diphosphate + propargoxyfarnesyl N-dansyl-Gly-Cys-Val-Ile-Ala-OH
-
-
-
-
?
3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate + dansyl-Gly-Cys-Lys-Thr-Gln
? + diphosphate
-
-
-
-
?
3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate + dansyl-Gly-Cys-Lys-Val-Leu
? + diphosphate
-
-
-
-
?
3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate + dansyl-Gly-Cys-Val-Ile-Met
? + diphosphate
-
-
-
-
?
3-(3-methyl-2-butenyl)-7,11-dimethyldodeca-2(Z),6(E),10-triene 1-diphosphate + dansyl-Gly-Cys-Val-Leu-Ser
? + diphosphate
-
-
-
-
?
3-(azidomethyl)-N-[(2E,6E,8E)-2,6-dimethyl-8-(oxodiphosphanylidene)octa-2,6-dien-1-yl]aniline + protein-cysteine
?
-
-
-
-
?
3-(azidomethyl)-N-[(4E,8E,10E)-4,8-dimethyl-10-(oxodiphosphanylidene)deca-4,8-dien-1-yl]aniline + protein-cysteine
?
-
-
-
-
?
6-benzyloxy-3-methyl-2-hexen-1-ol-diphosphate + N-dansyl-Gly-Cys-Val-Leu-Ser
diphosphate + N-dansyl-Gly-S-(6-benzyloxy-3-methyl-2-hexenyl)-Cys-Val-Leu-Ser
-
-
-
-
?
7-benzyloxy-3-methyl-2-hepten-1-ol-diphosphate + N-dansyl-Gly-Cys-Val-Leu-Ser
diphosphate + N-dansyl-Gly-S-(7-benzyloxy-3-methyl-2-heptenyl)-Cys-Val-Leu-Ser
-
-
-
-
?
8-benzyloxy-3-methyl-2-octen-1-ol-diphosphate + N-dansyl-Gly-Cys-Val-Leu-Ser
diphosphate + N-dansyl-Gly-S-(8-benzyloxy-3-methyl-2-octenyl)-Cys-Val-Leu-Ser
-
-
-
-
?
9-benzyloxy-3-methyl-2-nonen-1-ol-diphosphate + N-dansyl-Gly-Cys-Val-Leu-Ser
diphosphate + N-dansyl-Gly-S-(9-benzyloxy-3-methyl-2-nonenyl)-Cys-Val-Leu-Ser
-
-
-
-
?
CALQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CALQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CALV + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CALV + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CAVQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CAVQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CCIF + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CCIF + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CCIL + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CCIL + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CDVK + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CDVK + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CEIQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CEIQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CFLS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CFLS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CFPS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CFPS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CFTN + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CFTN + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CFVN + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CFVN + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CGIA + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CGIA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CGIM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CGIM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CGLF + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CGLF + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CGLY + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CGLY + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CGVV + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CGVV + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CHIM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CHIM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CHIQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CHIQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CHLM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CHLM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CHLS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CHLS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CHVM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CHVM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CHVQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CHVQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CIVA + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CIVA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CKIF + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CKIF + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CKIS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CKIS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CKIV + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CKIV + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CLIT + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CLIT + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CLLM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CLLM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CLLV + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CLLV + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CLML + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CLML + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CLTS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CLTS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CLVM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CLVM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CNIM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CNIM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CNLF + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CNLF + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CNLK + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CNLK + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CNLM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CNLM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CNLQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CNLQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CQTA + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CQTA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CRIS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CRIS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CSFM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSFM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CSIM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSIM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CSIS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSIS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CSLA + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSLA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CSLC + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSLC + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CSLG + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSLG + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CSLH + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSLH + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CSLM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSLM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CSVQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSVQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CSVS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CSVS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CTII + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTII + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CTIV + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTIV + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CTKF + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTKF + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CTLA + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTLA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CTLM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTLM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CTLQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTLQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CTMS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTMS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CTTQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTTQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CTVF + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTVF + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CTVS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTVS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CTVV + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CTVV + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CVHF + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CVHF + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CVLA + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CVLA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CVLH + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CVLH + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CVLQ + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CVLQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CVQM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CVQM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CVVT + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CVVT + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CYIS + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CYIS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CYLA + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CYLA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CYPD + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CYPD + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
CYVM + (2E,6E)-farnesyl diphosphate
S-(2E,6E)-farnesyl-CYVM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVAA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVAA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVAM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVAM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVAQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVAQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVAS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVAS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVCA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVCA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVCM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVCM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVCQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVCQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVCS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVCS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVDA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVDA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVDM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVDM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVDQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVDQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVDS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVDS + diphosphate
dansyl-GCVEA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVEA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVEM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVEM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVEQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVEQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVES + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVES + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVFA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVFA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVFM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVFM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVFQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVFQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVFS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVFS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVGA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVGA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVGM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVGM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVGQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVGQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVGS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVGS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVHA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVHA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVHM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVHM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVHQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVHQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVHS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVHS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVIA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVIA + diphosphate
dansyl-GCVIA + 1-(4,5-dimethoxy-nitrophenyl)ethyl (2E,6E)-farnesyl diphosphate
?
-
7.6% enzyme activity, specific activity 0.058 microM/min
-
-
?
dansyl-GCVIA + 2-nitrophenyl (2E,6E)-farnesyl diphosphate
?
-
14% enzyme activity, specific activity 0.104 microM/min
-
-
?
dansyl-GCVIM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVIM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVIQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVIQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVIS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVIS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVKA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVKA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVKLQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVLQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVKM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVKM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVKQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVKQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVKS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVKS + diphosphate
dansyl-GCVLA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVLA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVLM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVLM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVLS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVLS + diphosphate
dansyl-GCVLS + (E)-[4-[(3,7-dimethylocta-2,6-dien-1-yl)oxy]phenyl]-methanyl diphosphate
dansyl-G-(S-(E)-[4-[(3,7-dimethylocta-2,6-dien-1-yl)oxy]phenyl]-methanyl)CVLS + diphosphate
-
-
-
-
?
dansyl-GCVLS + [3-[(3-phenoxyphenoxy)methyl]phenyl]-methanyl diphosphate
dansyl-G-(S-[3-[(3-phenoxyphenoxy)methyl]phenyl]-methanyl)CVLS + diphosphate
-
-
-
-
?
dansyl-GCVMA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVMA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVMM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVMM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVMQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVMQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVMS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVMS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVNA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVNA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVNM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVNM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVNQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVNQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVNS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVNS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVPA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVPA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVPM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVPM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVPQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVPQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVPS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVPS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVQA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVQA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVQM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVQM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVQQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVQQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVQs + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVQS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVSA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVSA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVSM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVSM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVSQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVSQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVSS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVSS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVTA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVTA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVTM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVTM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVTQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVTQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVTS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVTS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVVA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVVA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVVM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVVM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVVQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVVQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVVS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVVS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVWA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVWA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVWM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVWM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVWQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVWQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVWS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVWS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVYA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVYA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVYM + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVYM + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVYQ + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVYQ + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVYS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVYS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
farnesyl diphosphate + dansyl-GCEV
diphosphate + farnesyl dansyl-GCEV
-
-
-
?
farnesyl diphosphate + dansyl-GCFT
diphosphate + farnesyl dansyl-GCFT
-
-
-
?
farnesyl diphosphate + dansyl-GCII
diphosphate + farnesyl dansyl-GCII
-
-
-
?
farnesyl diphosphate + dansyl-GCLL
diphosphate + farnesyl dansyl-GCLL
-
-
-
?
farnesyl diphosphate + dansyl-GCNV
diphosphate + farnesyl dansyl-GCNV
-
-
-
?
farnesyl diphosphate + dansyl-GCQL
diphosphate + farnesyl dansyl-GCQL
-
-
-
?
farnesyl diphosphate + dansyl-GCRL
diphosphate + farnesyl dansyl-GCRL
-
-
-
?
farnesyl diphosphate + dansyl-GCSV
diphosphate + farnesyl dansyl-GCSV
-
-
-
?
farnesyl diphosphate + dansyl-GCTV
diphosphate + farnesyl dansyl-GCTV
-
-
-
?
farnesyl diphosphate + dansyl-GCVL
diphosphate + farnesyl dansyl-GCVL
-
-
-
?
farnesyl diphosphate + dansyl-GCWI
diphosphate + farnesyl dansyl-GCWI
-
-
-
?
farnesyl diphosphate + dansyl-GCYL
diphosphate + farnesyl dansyl-GCYL
-
-
-
?
farnesyl diphosphate + dansyl-Gly-Cys-Lys-Thr-Gln
dansyl-Gly-S-farnesyl-Cys-Lys-Thr-Gln + diphosphate
-
-
-
-
?
farnesyl diphosphate + dansyl-Gly-Cys-Lys-Val-Leu
dansyl-Gly-S-farnesyl-Cys-Lys-Val-Leu + diphosphate
-
-
-
-
?
farnesyl diphosphate + dansyl-Gly-Cys-Val-Ile-Met
dansyl-Gly-S-farnesyl-Cys-Val-Ile-Met + diphosphate
-
-
-
-
?
farnesyl diphosphate + dansyl-Gly-Cys-Val-Leu-Ser
dansyl-Gly-S-farnesyl-Cys-Val-Leu-Ser + diphosphate
-
-
-
-
?
farnesyl diphosphate + GCVLS
Gly-S-farnesyl-Cys-Val-Leu-Ser + diphosphate
-
-
-
-
?
farnesyl diphosphate + GST-CIIL
diphosphate + S-farnesyl-GST-Cys-Ile-Ile-Ser
-
-
-
-
?
farnesyl diphosphate + GST-CIIS
?
-
GST-CIIS is glutathione S-transferase fused to the C-terminal 12 amino acids of yeast RAS2 protein
-
-
?
farnesyl diphosphate + human recombinant wild-type H-Ras-CVLS
diphosphate + ?
-
-
-
?
farnesyl diphosphate + mutant H-Ras-CVLL
diphosphate + ?
20fold less active than human recombinant wild-type H-Ras-CVLS
-
-
?
farnesyl diphosphate + N-dansyl-GCVLS
S-farnesyl-N-dansyl-GCVLS + diphosphate
-
-
-
-
?
farnesyl diphosphate + N-dansyl-Gly-Cys-Val-Leu-Ser
diphosphate + N-dansyl-Gly-S-farnesyl-Cys-Val-Leu-Ser
-
the best substrate
-
-
?
farnesyl diphosphate + Ras oncoprotein p21
diphosphate + Ras-S-farnesyl oncoprotein p21
-
-
-
-
?
farnesyl diphosphate + Ras protein
diphosphate + S-farnesyl Ras protein
-
-
-
-
?
farnesyl diphosphate + Ras-Cys-Val-Leu-Met
diphosphate + Ras-S-farnesyl-Cys-Val-Leu-Met
-
-
-
-
?
farnesyl diphosphate + Thr-Lys-Cys-Val-Ile-Leu
Thr-Lys-S-farnesyl-Cys-Val-Ile-Leu + diphosphate
-
-
-
-
?
farnesyl diphosphate + Thr-Lys-Cys-Val-Ile-Met
Thr-Lys-S-farnesyl-Cys-Val-Ile-Met + diphosphate
-
-
-
-
?
farnesyl diphosphate + Thr-Lys-Cys-Val-Ile-Phe
Thr-Lys-S-farnesyl-Cys-Val-Ile-Phe + diphosphate
-
-
-
-
?
farnesyl diphosphate + Thr-Lys-Cys-Val-Ile-Ser
Thr-Lys-S-farnesyl-Cys-Val-Ile-Ser + diphosphate
-
-
-
-
?
farnesyl diphosphate + Thr-Lys-Cys-Val-Leu-Ala
Thr-Lys-S-farnesyl-Cys-Val-Leu-Ala + diphosphate
-
-
-
-
?
farnesyl diphosphate + [GST]-Cys-Ile-Ile-Ser
diphosphate + S-farnesyl-[GST]-Cys-Ile-Ile-Ser
-
-
-
-
?
farnesyl diphosphate + [protein]-L-cysteine
[protein]-S-((2E,6E)-farnesyl)-L-cysteine + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
farnesyl monophosphate + Gly-Cys-Val-Leu-Ser
phosphate + Gly-S-farnesyl-Cys-Val-Leu-Ser
-
-
-
-
?
farnesyl triphosphate + [Ras]-Cys-Val-Ile-Met
triphosphate + [Ras]-S-farnesyl-Cys-Val-Ile-Met
-
-
-
-
?
geranyl alkyne diphosphate + N-dansyl-GCVIA
N-dansyl-G-(alkyne geranyl)CVIA + diphosphate
-
-
-
-
ir
geranyl diphosphate + dansyl-GCVLS
dansyl-G-(S-geranyl)CVLS + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + N-dansyl-Gly-Cys-Val-Leu-Ser
diphosphate + N-dansyl-Gly-S-geranylgeranyl-Cys-Val-Leu-Ser
-
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
diphosphate + S-geranylgeranylcysteinyl protein
-
-
-
-
?
YRASNRSCAIM + farnesyl diphosphate
YRASNRS-(S-farnesyl)CAIM + diphosphate
-
-
-
-
?
[(4E,8E,10E)-4,8-dimethyl-10-(oxodiphosphanylidene)deca-4,8-dien-1-yl]oxyacetonitrile + protein-cysteine
?
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine
S-(2E,6E)-farnesyl protein + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine
S-(2E,6E)-farnesyl protein + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + (protein)-L-cysteine
S-(2E,6E)-farnesyl protein + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-farnesyl)CVLS + diphosphate
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + dansyl-GCVLS
dansyl-G-(S-(2E,6E)-farnesyl)CVLS + diphosphate
-
assay at pH 7.5, 30°C
-
-
?
(2E,6E)-farnesyl diphosphate + [H Ras]-L-cysteine
S-(2E,6E)-farnesyl-[H Ras]-L-cysteine + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + [H Ras]-L-cysteine
S-(2E,6E)-farnesyl-[H Ras]-L-cysteine + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + [K Ras]-L-cysteine
S-(2E,6E)-farnesyl-[K Ras]-L-cysteine + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + [K Ras]-L-cysteine
S-(2E,6E)-farnesyl-[K Ras]-L-cysteine + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + [N Ras]-L-cysteine
S-(2E,6E)-farnesyl-[N Ras]-L-cysteine + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + [N Ras]-L-cysteine
S-(2E,6E)-farnesyl-[N Ras]-L-cysteine + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
-
the reaction is catalyzed by protein farnesyltransferase on protein substrates bearing the C-terminal CaaX motif
-
-
?
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
-
-
-
-
?
(2E,6E)-farnesyl diphosphate + [Rho]-L-cysteine
S-(2E,6E)-farnesyl-[Rho]-L-cysteine + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate + [Rho]-L-cysteine
S-(2E,6E)-farnesyl-[Rho]-L-cysteine + diphosphate
-
-
-
?
dansyl-GCVDS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVDS + diphosphate
-
poor substrate for wild-type
-
-
?
dansyl-GCVDS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVDS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVIA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVIA + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVIA + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVIA + diphosphate
-
100% enzyme activity, specific activity 0.765 microM/min
-
-
?
dansyl-GCVKS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVKS + diphosphate
-
poor substrate for wild-type
-
-
?
dansyl-GCVKS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVKS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
dansyl-GCVLS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVLS + diphosphate
-
-
-
-
?
dansyl-GCVLS + (2E,6E)-farnesyl diphosphate
dansyl-G-(S-(2E,6E)-farnesyl)CVLS + diphosphate
-
assay at pH 7.8, 25°C
-
-
?
farnesyl diphosphate + biotin-YRASNRSCAIM
diphosphate + biotin-YRASNRS-(S-farnesyl)CAIM
-
-
-
-
?
farnesyl diphosphate + biotin-YRASNRSCAIM
diphosphate + biotin-YRASNRS-(S-farnesyl)CAIM
-
-
-
-
?
farnesyl diphosphate + dansyl-GCVLS
diphosphate + S-farnesyl dansyl-GCVLS
-
-
-
?
farnesyl diphosphate + dansyl-GCVLS
diphosphate + S-farnesyl dansyl-GCVLS
-
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins, the reactive cysteine is located in the C-terminal Ca1a2X motif in which C is the modified cysteine, a1 and a2 are often an aliphatic residue, and X is Ser, Met, Ala or Gln
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
substrate: Ras-CVIM and GST-PEP
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
-
ir
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
Ftase has an autonomous recognition sequence, referred to as the CAAX box, where C is a cysteine, A is usually an aliphatic amino acid, and X can be a variety of amino acids
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
enzyme prefers Gln and Met at the X position but not Ser, Thr or Cys, which are good substrates for mammalian enzyme
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins, the reactive cysteine is located in the C-terminal Ca1a2X motif in which C is the modified cysteine, a1 and a2 are often an aliphatic residue, and X is Ser, Met, Ala or Gln
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
prenylation, farnesylation, substrates are Ras, nuclear lamins, transducin gamma subunit, protein substrate motif: Cys-aliphatic-aliphatic-X, X: M, S, Q, A, F
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins, the reactive cysteine is located in the C-terminal Ca1a2X motif in which C is the modified cysteine, a1 and a2 are often an aliphatic residue, and X is Ser, Met, Ala or Gln
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins, the reactive cysteine is located in the C-terminal Ca1a2X motif in which C is the modified cysteine, a1 and a2 are often an aliphatic residue, and X is Ser, Met, Ala or Gln
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins, the reactive cysteine is located in the C-terminal Ca1a2X motif in which C is the modified cysteine, a1 and a2 are often an aliphatic residue, and X is Ser, Met, Ala or Gln
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins, the reactive cysteine is located in the C-terminal Ca1a2X motif in which C is the modified cysteine, a1 and a2 are often an aliphatic residue, and X is Ser, Met, Ala or Gln
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins, the reactive cysteine is located in the C-terminal Ca1a2X motif in which C is the modified cysteine, a1 and a2 are often an aliphatic residue, and X is Ser, Met, Ala or Gln
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins, the reactive cysteine is located in the C-terminal Ca1a2X motif in which C is the modified cysteine, a1 and a2 are often an aliphatic residue, and X is Ser, Met, Ala or Gln
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins, the reactive cysteine is located in the C-terminal Ca1a2X motif in which C is the modified cysteine, a1 and a2 are often an aliphatic residue, and X is Ser, Met, Ala or Gln
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
Ha-Ras-CVLS, which is a good substrate for mammalian enzyme, not farnesylated by the parasite enzyme, only the mammalian enzyme substrate RAS1-CVIM farnesylated by parasite enzyme
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
substrate are: Ras superfamiliy and Ras-related proteins for example Rap, Rab, Rac and Ral, large G proteins, nuclear lamins, rhodopsin kinase and the retinal cGMP phosphodiesterase
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
substrate are: Ras superfamiliy and Ras-related proteins for example Rap, Rab, Rac and Ral, large G proteins, nuclear lamins, rhodopsin kinase and the retinal cGMP phosphodiesterase
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
enzyme prefers linear residues in the X position of the CaaX box over branched residues, enzyme prefers Gln, Met and Ser at the X position
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
substrates are cellular proteins such as Ras at a cysteine residue near their carboxy-terminus
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
prenylation, farnesylation, substrates are Ras, nuclear lamins, transducin gamma subunit, protein substrate motif: Cys-aliphatic-aliphatic-X, X: M, S, Q, A, F
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
prenylation, farnesylation, substrates are Ras, nuclear lamins, transducin gamma subunit, protein substrate motif: Cys-aliphatic-aliphatic-X, X: M, S, Q, A, F
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
prenylation, farnesylation, substrates are Ras, nuclear lamins, transducin gamma subunit, protein substrate motif: Cys-aliphatic-aliphatic-X, X: M, S, Q, A, F
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
prenylation, farnesylation, substrates are Ras, nuclear lamins, transducin gamma subunit, protein substrate motif: Cys-aliphatic-aliphatic-X, X: M, S, Q, A, F
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
prenylation, farnesylation, substrates are Ras, nuclear lamins, transducin gamma subunit, protein substrate motif: Cys-aliphatic-aliphatic-X, X: M, S, Q, A, F
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
prenylation, farnesylation, substrates are Ras, nuclear lamins, transducin gamma subunit, protein substrate motif: Cys-aliphatic-aliphatic-X, X: M, S, Q, A, F
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
prenylation, farnesylation, substrates are Ras, nuclear lamins, transducin gamma subunit, protein substrate motif: Cys-aliphatic-aliphatic-X, X: M, S, Q, A, F
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
prenylation, farnesylation, substrates are Ras, nuclear lamins, transducin gamma subunit, protein substrate motif: Cys-aliphatic-aliphatic-X, X: M, S, Q, A, F
-
ir
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
preferred CaaX-substrate: CAIM
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
-
-
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
prenylation, farnesylation, substrates are Ras, nuclear lamins, transducin gamma subunit, protein substrate motif: Cys-aliphatic-aliphatic-X, X: M, S, Q, A, F
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
prenylation, farnesylation, substrates are Ras, nuclear lamins, transducin gamma subunit, protein substrate motif: Cys-aliphatic-aliphatic-X, X: M, S, Q, A, F
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
preferred CaaX-substrate: CAIM
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
the specific CAQQ motif of the ANJ1 protein has a low affinity for enzyme in vitro, enzyme specifically farnesylated the RasB-CVIM peptide substrate
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
substrate: Biotin lamin-B protein
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
Ha-Ras-CVLS, which is a good substrate for mammalian enzyme, not farnesylated by the parasite enzyme, only the mammalian enzyme substrate RAS1-CVIM farnesylated by parasite enzyme
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
enzyme prefers Gln and Met at the X position but not Ser, Thr or Cys, which are good substrates for mammalian enzyme
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
enzyme prefers Gln and Met at the X position but not Ser, Thr or Cys, which are good substrates for mammalian enzyme
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
-
Ha-Ras-CVLS, which is a good substrate for mammalian enzyme, not farnesylated by the parasite enzyme, only the mammalian enzyme substrate RAS1-CVIM farnesylated by parasite enzyme
-
?
farnesyl diphosphate + protein-cysteine
diphosphate + S-farnesyl protein
enzyme prefers Gln and Met at the X position but not Ser, Thr or Cys, which are good substrates for mammalian enzyme
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
-
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
process required for the transforming activity of oncogenic variants of Ras, making enzyme a prime target for anticancer therapeutics
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
process necessary for the subcellular localisation of substrate to the plasma membrane
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
the enzyme catalyzes posttranslational modification of proteins, the farnesyl moieties attached to the substrates are direcly involved in protein-protein interactions as well as in protein-membrane interactions
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
substrate motif: carboxy-terminal -Ca1a2X box
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
protein farnesylation is essential for early embryonic proliferation but dispensable for postnatal development and adult homeostasis. Ablation of FTase during tumor progression results in significant tumor reduction
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
potential role for plant enzyme in cell cycle regulation
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
potential role for plant enzyme in cell cycle regulation
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
potential role for cell cycle
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
-
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
process required for the transforming activity of oncogenic variants of Ras, making enzyme a prime target for anticancer therapeutics
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
process necessary for the subcellular localisation of substrate to the plasma membrane
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
enzyme responsible for catalysing isoprene lipid modifications
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
A series of steps modifies the C-terminus of Ras. Enzyme catalyses the first of these steps by transferring the farnesyl group from farnesyl diphosphates to the cysteine side chain in the CAAX sequence motif at the C-terminus of Ras
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
catalyzes the post-translational modification of many important cellular proteins
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
-
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
process required for the transforming activity of oncogenic variants of Ras, making enzyme a prime target for anticancer therapeutics
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
process necessary for the subcellular localisation of substrate to the plasma membrane
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
a possible role for the enzyme during fruit development
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
enzyme responsible for catalysing isoprene lipid modifications
-
-
?
farnesyl diphosphate + Ras-Cys-Val-Ile-Met
diphosphate + Ras-S-farnesyl-Cys-Val-Ile-Met
-
-
-
-
?
farnesyl diphosphate + Ras-Cys-Val-Ile-Met
diphosphate + Ras-S-farnesyl-Cys-Val-Ile-Met
-
-
-
-
?
farnesyl diphosphate + Ras-Cys-Val-Ile-Met
diphosphate + Ras-S-farnesyl-Cys-Val-Ile-Met
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farnesyl diphosphate + Ras-Cys-Val-Ile-Met
diphosphate + Ras-S-farnesyl-Cys-Val-Ile-Met
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best substrate
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farnesyl diphosphate + Ras-Cys-Val-Ile-Met
diphosphate + Ras-S-farnesyl-Cys-Val-Ile-Met
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best substrate
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farnesyl diphosphate + Ras-Cys-Val-Ile-Met
diphosphate + Ras-S-farnesyl-Cys-Val-Ile-Met
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farnesyl diphosphate + Ras-Cys-Val-Ile-Met
diphosphate + Ras-S-farnesyl-Cys-Val-Ile-Met
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additional information
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protein farnesytransferase catalyzes the farnesylation of proteins with a C-terminal tetrapeptide sequence denoted as a Ca1a2X box, determination of substrate recognition sequences, and substrate specificity, screening of the CVa2X library with alkyne-functionalized isoprenoid substrates, detailed overview
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additional information
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biotin-GPP is not transferred to the peptide substrate to any measurable extent
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additional information
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FTase-I can transfer isoprenoids to intracellular proteins that contain CAAX motifs. The isoprenoid groups can be selectively recognized by GGTase-I. The 15-carbon isoprenoid geranylgeranyl from its donor farnesyldiphosphate (FPP) is specific to FTase-I. Residues Lysalpha164, Hisbeta248, Argbeta291 and Tyrbeta300 in FTase can form hydrogen bonds with farnesyl diphosphate. When FTase is inhibited by a FTI, N-Ras and K-Ras can be alternatively prenylated by GGTase-I, EC 2.5.1.59, but H-Ras cannot
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additional information
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FTase-I can transfer isoprenoids to intracellular proteins that contain CAAX motifs. The isoprenoid groups can be selectively recognized by GGTase-I. The 15-carbon isoprenoid geranylgeranyl from its donor farnesyldiphosphate (FPP) is specific to FTase-I. Residues Lysalpha164, Hisbeta248, Argbeta291 and Tyrbeta300 in FTase can form hydrogen bonds with farnesyl diphosphate. When FTase is inhibited by a FTI, N-Ras and K-Ras can be alternatively prenylated by GGTase-I, EC 2.5.1.59, but H-Ras cannot
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additional information
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enzyme-substrate interaction study using synthetic peptides as substrates, modelling of the enzyme interaction with substrate protein tyrosine phosphatase, protein-protein docking and molecular dynamics simulation, overview
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additional information
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although farnesyl diphosphate and geranylgeranyl diphosphate bind competitively, the geranyl geranyl diphosphate is not transferred efficiently to the protein substrate by enzyme
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additional information
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steady-state kinetics for modification of peptide substrates shows that the multiple-turnover activity depends on the analogue structure. Analogues in which the first isoprene is replaced with a benzyl group and an analogue in which each isoprene is replaced with an aryl group are good substrates. The single-turnover rate constant for alkylation depends on the Ca1a2X peptide sequence. The isoprenoid transition-state conformation is preferred over the inactive E-FPP-Ca1a2X ternary complex conformation and the farnesyl binding site in the exit groove may be significantly more selective for the farnesyl diphosphate substrate than the active site binding pocket
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additional information
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ligand interaction analysis with FTase alpha subunit, mass spectrometry, overview. The enzyme alpha-subunit interacts with Vps4A protein in vitro and in vivo
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additional information
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analogues of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase, reactivity of four alkyne-containing analogs of farnesyl diphosphate with purified protein farnesyltransferase and a small library of dansylated peptides using an in vitro continuous spectrofluorimetric assay, overview. Activity with CGGDD, CVLL, and CSVL peptides is low with farnesyl diphosphate as well as with its analogues
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additional information
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FTase-I can transfer isoprenoids to intracellular proteins that contain CAAX motifs. The isoprenoid groups can be selectively recognized by GGTase-I. The 15-carbon isoprenoid geranylgeranyl from its donor farnesyldiphosphate (FPP) is specific to FTase-I. Residues Lysalpha164, Hisbeta248, Argbeta291 and Tyrbeta300 in FTase can form hydrogen bonds with farnesyl diphosphate. When FTase is inhibited by a FTI, N-Ras and K-Ras can be alternatively prenylated by GGTase-I, EC 2.5.1.59, but H-Ras cannot
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additional information
?
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FTase-I can transfer isoprenoids to intracellular proteins that contain CAAX motifs. The isoprenoid groups can be selectively recognized by GGTase-I. The 15-carbon isoprenoid geranylgeranyl from its donor farnesyldiphosphate (FPP) is specific to FTase-I. Residues Lysalpha164, Hisbeta248, Argbeta291 and Tyrbeta300 in FTase can form hydrogen bonds with farnesyl diphosphate. When FTase is inhibited by a FTI, N-Ras and K-Ras can be alternatively prenylated by GGTase-I, EC 2.5.1.59, but H-Ras cannot
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additional information
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protein farnesytransferase catalyzes the farnesylation of proteins with a C-terminal tetrapeptide sequence denoted as a Ca1a2X box, determination of substrate recognition sequences, and substrate specificity, screening of the CVa2X library with alkyne-functionalized isoprenoid substrates, detailed overview
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additional information
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protein farnesytransferase catalyzes the farnesylation of proteins with a C-terminal tetrapeptide sequence denoted as a Ca1a2X box, determination of substrate recognition sequences, and substrate specificity, screening of the CVa2X library with alkyne-functionalized isoprenoid substrates, detailed overview
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additional information
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enzyme prefers farnesyl diphosphate over geranylgeranyl diphosphate, but catalyzes the reactions of both substrates, i.e. reactions of EC 2.5.1.58 and EC 2.5.1.59, respectively
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additional information
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ligand interaction analysis with FTase alpha subunit, mass spectrometry, overview. The enzyme alpha-subunit interacts with Vps4A protein in vitro and in vivo
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additional information
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protein farnesytransferase catalyzes the farnesylation of proteins with a C-terminal tetrapeptide sequence denoted as a Ca1a2X box, determination of substrate recognition sequences, and substrate specificity, screening of the CVa2X library with alkyne-functionalized isoprenoid substrates, detailed overview
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additional information
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protein farnesytransferase catalyzes the farnesylation of proteins with a C-terminal tetrapeptide sequence denoted as a Ca1a2X box, determination of substrate recognition sequences, and substrate specificity, screening of the CVa2X library with alkyne-functionalized isoprenoid substrates, detailed overview
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