2.5.1.58: protein farnesyltransferase
This is an abbreviated version!
For detailed information about protein farnesyltransferase, go to the full flat file.
Word Map on EC 2.5.1.58
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2.5.1.58
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farnesylation
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prenylation
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geranylgeranylation
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isoprenoids
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beta-subunits
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isoprenylation
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15-carbon
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lamins
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manumycin
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geranylgeranyltransferase-i
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farnesyl-protein
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h-ras
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medicine
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peptidomimetic
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prelamin
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ggtase-i
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p21ras
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tetrapeptide
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farnesol
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tetrahydroquinoline
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ras-dependent
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pharmacology
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progerin
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3hmevalonate
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ras-induced
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lovastatin
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tipifarnib
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drug development
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ras-mediated
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ras-transformed
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lonafarnib
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hutchinson-gilford
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dimethylallyl
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geranylgeraniol
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isoprene
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analysis
- 2.5.1.58
-
farnesylation
-
prenylation
-
geranylgeranylation
-
isoprenoids
- beta-subunits
-
isoprenylation
-
15-carbon
- lamins
- manumycin
-
geranylgeranyltransferase-i
-
farnesyl-protein
- h-ras
- medicine
-
peptidomimetic
-
prelamin
- ggtase-i
-
p21ras
- tetrapeptide
- farnesol
- tetrahydroquinoline
-
ras-dependent
- pharmacology
-
progerin
-
3hmevalonate
-
ras-induced
- lovastatin
- tipifarnib
- drug development
-
ras-mediated
-
ras-transformed
- lonafarnib
-
hutchinson-gilford
-
dimethylallyl
- geranylgeraniol
- isoprene
- analysis
Reaction
Synonyms
AfFTase, CAAX farnesyltransferase, EhFT, Era1, farnesyl protein transferase, farnesyltransferase, farnesyltransferase ternary complex part II, farnesyltransferase, farnesyl pyrophosphate-protein, farnesyltransferase, protein, FntA, FntB, FPT, fptase, FTase, hFTase, HIT5, Pf-PFT, PfPFT, PFT, PFTase, prenyl transferase, prenylprotein transferase, prenyltransferase, protein cysteine farnesyltransferase, protein farnesyl transferase, protein farnesyltransferase, protein prenyltransferase, protein-farnesyltransferase, R-PFT, Ram1, RAS farnesyltransferase, Ras protein farnesyltransferase, rFPTase, rFTase, rPFTase, TbFTase, yPFTase
ECTree
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Reaction
Reaction on EC 2.5.1.58 - protein farnesyltransferase
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kinetic mechanism
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farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate
kinetic mechanism
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farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate
enzyme constitutes the protein prenyltransferase family of enzymes
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farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate
enzyme constitutes the protein prenyltransferase family of enzymes
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farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate
farnesyl diphosphate binds exclusively to the beta subunit
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farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate
leucine makes the protein a substrate for EC 2.5.1.59. The enzymes are relaxed in specificity for A1, but cannot act if A2 is aromatic. Substrates of prenyltransferases include Ras, Rho, Rab, other Ras-related small GTP-binding proteins, gamma-subunits of heteotrimeric G-proteins, nuclear lamins, centromeric proteins and many proteins involved in visual signal transduction. A zinc metalloenzyme that requires Mg2+ for activity
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farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate
farnesyl diphosphate binds the enzyme in a two step process that may involve an enzyme conformational change, the enzyme-substrate complex then rapidly reacts with the peptide substrate to form a product, and product release is the rate-limiting step in catalysis
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farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate
farnesyl diphosphate binds the enzyme in a two step process that may involve an enzyme conformational change, the enzyme-substrate complex then rapidly reacts with the peptide substrate to form a product, and product release is the rate-limiting step in catalysis
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farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate
both subunits would appear to have a role in binding and orienting the leaving group of farnesyl diphosphate approximately for catalysis
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farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate
The enzyme preferentially farnesylates CaaX sequences ending in methionine, cysteine or serine. Enzyme also attaches geranylgeraniol to some CaaX sequences ending in methionine, leucine and cysteine. Substrate overlap may occur between the Saccharomyces cerevisae farnesyl transferase and geranylgeranyltransferase types I in vivo
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farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate
This enzyme, along with geranylgeranyltransferase types I, EC 2.5.1.59 and II, EC 2.5.1.60, constitutes the protein prenyltransferase family of enzymes. Catalyses the formation of a thioether linkage between the C-1 of an isoprenyl group and a cysteine residue fourth from the C-terminus of the protein. These protein acceptors have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably serine, methionine, alanine or glutamine
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