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2.5.1.58: protein farnesyltransferase

This is an abbreviated version!
For detailed information about protein farnesyltransferase, go to the full flat file.

Word Map on EC 2.5.1.58

Reaction

farnesyl diphosphate
+
protein-cysteine
=
S-farnesyl protein
 +
diphosphate

Synonyms

AfFTase, CAAX farnesyltransferase, EhFT, Era1, farnesyl protein transferase, farnesyltransferase, farnesyltransferase ternary complex part II, farnesyltransferase, farnesyl pyrophosphate-protein, farnesyltransferase, protein, FntA, FntB, FPT, fptase, FTase, hFTase, HIT5, Pf-PFT, PfPFT, PFT, PFTase, prenyl transferase, prenylprotein transferase, prenyltransferase, protein cysteine farnesyltransferase, protein farnesyl transferase, protein farnesyltransferase, protein prenyltransferase, protein-farnesyltransferase, R-PFT, Ram1, RAS farnesyltransferase, Ras protein farnesyltransferase, rFPTase, rFTase, rPFTase, TbFTase, yPFTase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.58 protein farnesyltransferase

IC50 Value

IC50 Value on EC 2.5.1.58 - protein farnesyltransferase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.09
(1aR,2S,3aS,6aR,7aR)-2,6-dimethyl-1a-[(1E)-3-oxobut-1-en-1-yl]octahydro-5H-oxireno[4,5]cyclohepta[1,2-b]furan-5-one
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.1
(1aR,2S,3aS,6aR,7aR)-2-methyl-6-methylidene-1a-[(1E)-3-oxobut-1-en-1-yl]octahydro-5H-oxireno[4,5]cyclohepta[1,2-b]furan-5-one
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.066
(1aS,2S,3aS,6aR,7aS)-2,6-dimethyl-1a-[(1E)-3-oxobut-1-en-1-yl]octahydro-5H-oxireno[4,5]cyclohepta[1,2-b]furan-5-one
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.5
(1aS,2S,3aS,6aR,7aS)-2-methyl-6-methylidene-1a-[(1E)-3-oxobut-1-en-1-yl]octahydro-5H-oxireno[4,5]cyclohepta[1,2-b]furan-5-one
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.0018
(1R,4aR,5R,7S)-5-[[(1R,4aR,8aS)-8a-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-6-methoxy-5,8-dioxo-1,4,4a,5,8,8a-hexahydronaphthalen-1-yl]methyl]-7-hydroxy-1,4a-dimethyl-6-methylidenedecahydronaphthalene-1-carbaldehyde
Rattus norvegicus
-
30°C, pH 7.5
0.04
(1R,4aR,5R,7S)-5-[[(1R,4aR,8aS)-8a-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-6-methoxy-5,8-dioxo-1,4,4a,5,8,8a-hexahydronaphthalen-1-yl]methyl]-7-hydroxy-1,4a-dimethyl-6-methylidenedecahydronaphthalene-1-carboxylic acid
Rattus norvegicus
-
30°C, pH 7.5
0.00053
(2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-1-[2-(methylsulfanyl)ethyl]hydrazinyl)acetic acid
Trypanosoma brucei
-
pH and temperature not specified in the publication
0.0065 - 0.016
(2E)-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylidene]butanedioic acid
0.9
(2E)-3-[(3aR,7S,8aS)-3,7-dimethyl-2-oxo-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-6-yl]-1-methylprop-2-en-1-yl acetate
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.04 - 0.13
(2E,4E,8E)-5,9,13-trimethyltetradeca-2,4,8,12-tetraenoic acid
0.012 - 0.175
(2Z,4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-2,4,8,12-tetraenoic acid
0.000016
(2Z,6E)-3-(3-methylbut-2-enyl)-7,11-dimethyldodeca-2,6,10-triene monophosphate
Homo sapiens
-
IC50: 16 nM
0.000013
(2Z,6E)-3-tert-butyl-7,11-dimethyldodeca-2,6,10-triene monophosphate
Homo sapiens
-
IC50: 13 nM
0.21
(3aR,7S,8aS)-3,7-dimethyl-6-[(1E)-3-oxobut-1-en-1-yl]-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one
Saccharomyces cerevisiae
-
30°C, pH 7.5
1
(3aR,7S,8aS)-6-[(1E)-3-hydroxybut-1-en-1-yl]-3,7-dimethyl-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one
Saccharomyces cerevisiae
-
value above, 30°C, pH 7.5
0.1
(3aR,7S,8aS)-7-methyl-3-methylidene-6-[(1E)-3-oxobut-1-en-1-yl]-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one
Saccharomyces cerevisiae
-
30°C, pH 7.5
1
(3aR,8S,9aS)-6-acetyl-3,8-dimethyl-3,3a,4,8,9,9a-hexahydro-2H-cyclohepta[1,2-b:4,5-b']difuran-2-one
Saccharomyces cerevisiae
-
value above, 330°C, pH 7.5
0.24
(3R,3aR,7S,8aS)-3,7-dimethyl-6-(3-oxobutyl)-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one
Saccharomyces cerevisiae
-
30°C, pH 7.5
1
(3R,3aR,7S,8aS)-6-(3-hydroxybutyl)-3,7-dimethyl-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one
Saccharomyces cerevisiae
-
value above, 30°C, pH 7.5
0.086
(4aS,5R,8aR)-4a-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxy-5-[[(1S,3S,7S,8aS)-1,3,7-trihydroxy-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]methyl]-4a,5,8,8a-tetrahydronaphthalene-1,4-dione
Rattus norvegicus
-
30°C, pH 7.5
0.0032
(4aS,5R,8aR)-4a-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxy-6-methyl-5-[[(1R,8aS)-5,5,8a-trimethyl-2-methylidene-3-oxodecahydronaphthalen-1-yl]methyl]-4a,5,8,8a-tetrahydronaphthalene-1,4-dione
Rattus norvegicus
-
30°C, pH 7.5
0.01
(4aS,5R,8aR)-4a-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-5-[[(1R,3S,5R,8aS)-3-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]methyl]-2-methoxy-4a,5,8,8a-tetrahydronaphthalene-1,4-dione
Rattus norvegicus
-
30°C, pH 7.5
0.04
(4aS,5R,8aR)-4a-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-5-[[(1R,3S,7S,8aS)-3,7-dihydroxy-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]methyl]-2-methoxy-4a,5,8,8a-tetrahydronaphthalene-1,4-dione
Rattus norvegicus
-
30°C, pH 7.5
0.0057
(4aS,5R,8aR)-4a-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-5-[[(1R,3S,8aS)-3-hydroxy-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]methyl]-2-methoxy-4a,5,8,8a-tetrahydronaphthalene-1,4-dione
Rattus norvegicus
-
30°C, pH 7.5
0.003
(4aS,5R,8aR)-4a-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxy-6-methyl-5-[[(1R,8aS)-5,5,8a-trimethyl-2-methylidene-3-oxodecahydronaphthalen-1-yl]methyl]-4a,5,8,8a-tetrahydronaphthalene-1,4-dione
Rattus norvegicus
-
30°C, pH 7.5
0.017
(4aS,5S,8aR)-4a-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-5-[[(1R,2R,7S,8aS)-2,7-dihydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]methyl]-6-hydroxy-2-methoxy-4a,5,8,8a-tetrahydronaphthalene-1,4-dione
Rattus norvegicus
-
30°C, pH 7.5
0.5 - 0.7
(4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-4,8,12-trienoic acid
0.2
(4E,8E)-5,9,13-trimethyl-N-(phenylsulfonyl)tetradeca-4,8,12-trienamide
0.2
(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienamide
Homo sapiens
-
value above, 30°C, pH 7.5
0.042 - 0.17
(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoic acid
0.0104 - 0.029
(4S)-4-([[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]amino)-5-tert-butoxy-5-oxopentanoic acid
0.08 - 0.2
(6E,10E)-7,11,15-trimethyl-3-oxohexadeca-6,10,14-trienoic acid
0.015 - 0.06
(7E,11E)-8,12,16-trimethyl-4-oxoheptadeca-7,11,15-trienoic acid
0.0131
(S)-N-(4-(3,4-dichlorophenoxy)benzyl)-6-(1H-indol-3-yl)piperazine-2,5-dione
Rattus norvegicus
-
pH 7.4, 30°C
0.0178
(S)-N-(4-(3-chlorophenoxy)benzyl)-6-(1H-indol-3-yl)piperazine-2,5-dione
Rattus norvegicus
-
pH 7.4, 30°C
0.037
1,4,8,10-tetrahydroxy-6-[(1E)-3-[(3S,8aS)-3-hydroxy-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]-1-methylprop-1-en-1-yl]-5,6-dihydro-7H-benzo[c]xanthen-7-one
Rattus norvegicus
-
30°C, pH 7.5
0.0259
1-(1-[3,4-bis[(hydroxyacetyl)amino]phenyl]-4,4-dicyano-1-oxobut-3-en-2-yl)-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.000024
1-(1H-imidazol-5-ylmethyl)-7-pyridin-4-yl-4-[[2-(trifluoromethoxy)phenyl]carbonyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine
Homo sapiens
-
-
0.0462
1-(4,4-dicyano-1-oxo-1-phenylbut-3-en-2-yl)-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0000075
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-yl-methyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(3-methoxy-propyl)-amide
Rattus norvegicus
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100
0.0000034
1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(5-methylisoxazol-4-yl)methyl]-1H-imidazole-4-sulfonamide
Rattus norvegicus
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100
0.0000048
1-methylethyl 4-[([1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)methyl]piperidine-1-carboxylate
Rattus norvegicus
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100
0.633
1-[(3aR,7S,8aS)-3,7-dimethyl-2-oxo-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-6-yl]-3-(1-hydroxyethoxy)butyl acetate
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.04
1-[(3aR,7S,8aS)-3,7-dimethyl-2-oxo-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-6-yl]butane-1,3-diyl diacetate
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.15
1-[(3aR,7S,8aS)-7-methyl-3-methylidene-2-oxo-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-6-yl]-3-oxobutyl acetate
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.04
1-[(3aR,7S,8aS)-7-methyl-3-methylidene-2-oxo-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-6-yl]butane-1,3-diyl diacetate
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.0364
1-[(3Z)-1-(4-bromophenyl)-4-cyano-5,5-dihydroxy-1-oxohept-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0319
1-[(3Z)-1-(4-chlorophenyl)-4-cyano-5,5-dihydroxy-1-oxohept-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
55.22
1-[(3Z)-1-[3,4-bis[(hydroxyacetyl)amino]phenyl]-4-cyano-5,5-dihydroxy-1-oxohept-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0208
1-[(3Z)-4-cyano-1-(3,4-dimethoxyphenyl)-5,5-dihydroxy-1-oxohept-3-en-2-yl]-3-methoxypyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0239
1-[(3Z)-4-cyano-1-(4-cyanophenyl)-5,5-dihydroxy-1-oxohept-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0623
1-[(3Z)-4-cyano-1-(4-fluorophenyl)-5,5-dihydroxy-1-oxohept-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0627
1-[(3Z)-4-cyano-5,5-dihydroxy-1-(4-methoxyphenyl)-1-oxohept-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0436
1-[(3Z)-4-cyano-5,5-dihydroxy-1-(4-methylphenyl)-1-oxohept-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0435
1-[(3Z)-4-cyano-5,5-dihydroxy-1-oxo-1-(3,4,5-trimethoxyphenyl)hept-3-en-2-yl]-2,4-dimethylpyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.048
1-[(3Z)-4-cyano-5,5-dihydroxy-1-oxo-1-(3,4,5-trimethoxyphenyl)hept-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0309
1-[(3Z)-4-cyano-5,5-dihydroxy-1-oxo-1-phenylhept-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0197
1-[1-(4-bromophenyl)-4,4-dicyano-1-oxobut-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0125
1-[1-(4-chlorophenyl)-4,4-dicyano-1-oxobut-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0314
1-[4,4-dicyano-1-(3,4-dimethoxyphenyl)-1-oxobut-3-en-2-yl]-3-methoxypyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0462
1-[4,4-dicyano-1-(4-cyanophenyl)-1-oxobut-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0236
1-[4,4-dicyano-1-(4-fluorophenyl)-1-oxobut-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0274
1-[4,4-dicyano-1-(4-methoxyphenyl)-1-oxobut-3-en-2-yl]-2,4-dimethylpyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0222
1-[4,4-dicyano-1-(4-methoxyphenyl)-1-oxobut-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0273
1-[4,4-dicyano-1-(4-methoxyphenyl)-1-oxobut-3-en-2-yl]-3-methoxypyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0145
1-[4,4-dicyano-1-(4-methylphenyl)-1-oxobut-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0282
1-[4,4-dicyano-1-(4-nitrophenyl)-1-oxobut-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0201
1-[4,4-dicyano-1-oxo-1-(3,4,5-trimethoxyphenyl)but-3-en-2-yl]-2,4-dimethylpyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0156
1-[4,4-dicyano-1-oxo-1-(3,4,5-trimethoxyphenyl)but-3-en-2-yl]-3-(dimethylamino)pyridinium
Homo sapiens
-
pH and temperature not specified in the publication
0.0000002
18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,5.113,17.07,11.022,26]triaconta-1(26),7,9,13(28),14,16,19,21,22,24,26-undecaene-16-carbonitrile
Homo sapiens
-
-
0.000001
2-amino-3-[2-butyl-4-(naphthalen-1-ylcarbonyl)piperazin-1-yl]propane-1-thiol
Homo sapiens
-
IC50 less than 0.000001 mM
0.59 - 0.85
2-[(2E)-3,7-dimethyl-1-(1-methyl-1H-imidazol-2-yl)octa-2,6-dien-1-yl]butanedioic acid
0.0025 - 0.0054
2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]butanedioic acid
0.000001
29-oxo-18-oxa-2,6,9,11-tetraazahexacyclo[17.5.3.12,5.113,17.07,11.022,26]nonacosa-7,9,13(28),14,16,19,21,26-octaene-16-carbonitrile
Homo sapiens
-
IC50 less than 0.000001 mM
0.047
3-(4-chlorophenyl)-4-cyano-1-methyl-5-[(1-methylethyl)sulfanyl]-1H-pyrrole-2-carboxylic acid
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.00145
3-(4-chlorophenyl)-4-cyano-5-(cyclohexylsulfanyl)thiophene-2-carboxylic acid
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.000325
3-(4-chlorophenyl)-4-cyano-5-(ethylsulfanyl)thiophene-2-carboxylic acid
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.00011 - 0.016
3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxylic acid
0.00061
3-(4-chlorophenyl)-4-cyano-5-(methylsulfanyl)thiophene-2-carboxylic acid
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.028
3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-ylsulfanyl)thiophene-2-carboxylic acid
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.05
3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)-N-adamantylthiophene-2-carboxamide
0.011 - 0.016
3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
0.002
3-(4-chlorophenyl)-4-cyano-5-[(1-methylethyl)sulfanyl]furan-2-carboxylic acid
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.0011
3-(4-chlorophenyl)-4-cyano-5-[(1-methylethyl)sulfanyl]thiophene-2-carboxamide
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.00011
3-(4-chlorophenyl)-4-cyano-5-[(1-methylethyl)sulfanyl]thiophene-2-carboxylic acid
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.000345
3-(4-chlorophenyl)-4-cyano-5-[(1-methylpropyl)sulfanyl]thiophene-2-carboxylic acid
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.00089
3-(4-chlorophenyl)-4-cyano-5-[(2-methylpropyl)sulfanyl]thiophene-2-carboxylic acid
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.0019
3-(4-chlorophenyl)-4-cyano-N'-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carbohydrazide
0.0216 - 0.05
3-(4-chlorophenyl)-4-cyano-N-(naphthalen-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide
0.022
3-(4-chlorophenyl)-4-cyano-N-cyclopropyl-5-[(1-methylethyl)sulfanyl]thiophene-2-carboxamide
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.024
3-(4-chlorophenyl)-4-cyano-N-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide
0.00094 - 0.0012
3-(4-chlorophenyl)-4-ethynyl-5-(2l5-triaz-1-en-2-yn-1-yl)thiophene-2-carboxylic acid
0.013 - 0.022
3-(4-chlorophenyl)-4-ethynyl-5-[(1H-imidazol-4-ylacetyl)amino]thiophene-2-carboxylic acid
0.00097 - 0.064
3-(4-chlorophenyl)-5-([[1-(4-cyanobenzyl)-1H-imidazol-4-yl]methyl][[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]amino)-4-ethynylthiophene-2-carboxylic acid
0.00064 - 0.0054
3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
0.000189
3-allylfarnesyl diphosphate
Homo sapiens
-
IC50: 189 nM
1
3-hydroxy-1-[(3aR,7S,8aS)-7-methyl-3-methylidene-2-oxo-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-6-yl]butyl acetate
Saccharomyces cerevisiae
-
value above, 30°C, pH 7.5
0.00335
3-methyl-2-[2-oxo-2-(10H-phenothiazin-10-yl)ethyl]indeno[1,2-c]pyrazol-4(2H)-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.08 - 0.16
3-oxo-3-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]propanoic acid
0.000031
3-tert-butylfarnesyl diphosphate
Homo sapiens
-
IC50: 31 nM
0.00007 - 0.0008
3-[3-[2-([2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-1-([(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]methyl)ethyl]sulfamoyl)benzyl]phenyl]propanoic acid
0.00000037
4-(3-{[(4-cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-methyl}-phenyl)-pyridine-2-carbonitrile
Rattus norvegicus
-
IC50: 0.37 nM, selective inhibitor
0.051
4-(4-chlorophenyl)-2-[(1-methylethyl)sulfanyl]-1,3-thiazole-5-carboxylic acid
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.0000075
4-(4-chlorophenyl)-5-(hydroxyacetyl)-2-[(1-methylethyl)sulfanyl]thiophene-3-carbonitrile
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.0057
4-(4-chlorophenyl)-5-(methoxyacetyl)-2-[(1-methylethyl)sulfanyl]thiophene-3-carbonitrile
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.00046 - 0.039
4-cyano-3-(3-fluorophenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
0.00027 - 0.029
4-cyano-3-(4-fluorophenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
0.00025 - 0.007
4-cyano-3-(4-methoxyphenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
0.001 - 0.015
4-cyano-3-(dibenzo[b,d]furan-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
0.00032 - 0.032
4-cyano-3-(naphthalen-2-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
0.00062 - 0.0097
4-cyano-3-[3-(methoxycarbonyl)phenyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
0.00001 - 0.01
4-ethynyl-5-([[1-(4-nitrobenzyl)-1H-imidazol-5-yl]methyl]amino)-3-phenylthiophene-2-carboxylic acid
0.1 - 0.13
4-oxo-4-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]butanoic acid
0.00000045
4-[(3'-Chloro-biphenyl-3-ylmethyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile
Rattus norvegicus
-
IC50: 0.45 nM, selective inhibitor
0.000039
4-[(3-cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile
Rattus norvegicus
-
IC50: 0.39 nM, selective inhibitor
0.000031
4-[(3-Methyl-3H-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile
Rattus norvegicus
-
IC50: 31 nM
0.0000015
4-[(4-cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile
Rattus norvegicus
-
IC50: 1.5 nM, selective inhibitor
0.000285
4-[(5-[[4-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)azepan-1-yl]methyl]-1H-imidazol-1-yl)methyl]benzonitrile
Homo sapiens
-
-
0.00031
4-[(5-[[4-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)piperidin-1-yl]methyl]-1H-imidazol-1-yl)methyl]benzonitrile
Homo sapiens
-
-
0.0000465
4-[(5-[[4-(5-oxido-7-propyl-7,12-dihydrodibenzo[c,f][1,2,8]oxathiazocin-12-yl)azepan-1-yl]methyl]-1H-imidazol-1-yl)methyl]benzonitrile
Homo sapiens
-
-
0.000043
4-[(5-[[4-(7-butyl-5-oxido-7,12-dihydrodibenzo[c,f][1,2,8]oxathiazocin-12-yl)azepan-1-yl]methyl]-1H-imidazol-1-yl)methyl]benzonitrile
Homo sapiens
-
-
0.0000448
4-[(5-[[4-(7-methyl-5-oxido-7,12-dihydrodibenzo[c,f][1,2,8]oxathiazocin-12-yl)azepan-1-yl]methyl]-1H-imidazol-1-yl)methyl]benzonitrile
Homo sapiens
-
-
0.000045
4-[(5-[[4-(7-methyl-5-oxido-7,12-dihydrodibenzo[c,f][1,2,8]oxathiazocin-12-yl)piperidin-1-yl]methyl]-1H-imidazol-1-yl)methyl]benzonitrile
Homo sapiens
-
-
0.0373
4-[5-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1,2-oxazol-3-yl]-N,N-dimethylaniline
Homo sapiens
pH 7.5, 30°C
0.0000015
4-[Biphenyl-3-ylmethyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile
Rattus norvegicus
-
IC50: 1.5 nM
0.0000019
4-[Hexyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile
Rattus norvegicus
-
IC50: 1.9 nM
0.000038
4-[Methyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile
Rattus norvegicus
-
IC50: 38 nM
0.0000017
4-[N, N -bis((1H-imidazol-4-yl)methyl)aminomethyl]-2-(1-(o-tolyl))benzoylmethionine trifluoroacetate
Mus musculus
-
IC50: 1.7 nM
0.0000095
4-[N-(1-H-imidazol-4-yl)methylamino]-2-(2-methoxyphenyl)-benzoylmethionine
Mus musculus
-
IC50: 9.5 nM
0.0000028
4-[N-(1-H-imidazol-4-yl)methylamino]-2-(2-methylphenyl)-benzoylmethionine
Mus musculus
-
IC50: 2.8 nM
0.000028
4-[N-(1H-imidazol-4-yl)methylamino]-2-phenylbenzoylmethionine
Mus musculus
-
IC50: 28 nM
0.0051
4-[[4-([[4-(4-chlorophenyl)-3-ethynylthiophen-2-yl]amino]methyl)-1H-imidazol-1-yl]methyl]benzonitrile
Homo sapiens
-
pH 7.5, 30°C
0.0000173
4-[[5-([4-[7-(3-morpholin-4-ylpropyl)-5-oxido-7,12-dihydrodibenzo[c,f][1,2,8]oxathiazocin-12-yl]azepan-1-yl]methyl)-1H-imidazol-1-yl]methyl]benzonitrile
Homo sapiens
-
-
0.00000065
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid ethylamide
Plasmodium falciparum
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100
0.0000014 - 0.000025
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid isobutyl ester
0.00000058 - 0.0000032
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester
0.025
5,7-dihydroxy-2-[(5R)-1-hydroxy-5-[[(3S,8aS)-3-hydroxy-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]methyl]-2-methoxy-6-methyl-4-oxo-1,5,8,8a-tetrahydronaphthalen-4a(4H)-yl]-4H-chromen-4-one
Rattus norvegicus
-
30°C, pH 7.5
0.007
5,7-dihydroxy-2-[(5R)-1-hydroxy-5-[[(3S,8aS)-3-hydroxy-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]methyl]-6-methyl-2-oxo-1,5,8,8a-tetrahydronaphthalen-4a(2H)-yl]-4H-chromen-4-one
Rattus norvegicus
-
30°C, pH 7.5
0.0038
5-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1-(4-methoxyphenyl)pyrrolidin-2-thione
Homo sapiens
pH 7.5, 30°C
0.0411
5-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1-[3-(trifluoromethyl)phenyl]pyrrolidine-2-thione
Homo sapiens
pH 7.5, 30°C
0.02
5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophene-2-carboxylic acid
Homo sapiens
-
about, pH and temperature not specified in the publication
0.00124
5-(butylsulfanyl)-3-(4-chlorophenyl)-4-cyanothiophene-2-carboxylic acid
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.00037 - 0.018
5-([[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]amino)-4-ethynyl-3-phenylthiophene-2-carboxylic acid
0.00079
5-acetyl-4-(4-chlorophenyl)-2-[(1-methylethyl)sulfanyl]thiophene-3-carbonitrile
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.035 - 0.06
5-oxo-5-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]pentanoic acid
0.00000097
5-[(3-cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2'-methyl-biphenyl-2-carbonitrile
Rattus norvegicus
-
IC50: 0.97 nM, selective inhibitor
0.00001
5-[(4-cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2'-methyl-biphenyl-2-carbonitrile
Rattus norvegicus
-
IC50: 10 nM, selective inhibitor
0.00064 - 0.055
5-[(tert-butoxycarbonyl)[[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]amino]-3-(4-chlorophenyl)-4-ethynylthiophene-2-carboxylic acid
0.00038 - 0.036
5-[(tert-butoxycarbonyl)[[1-(4-nitrobenzyl)-1H-imidazol-4-yl]methyl]amino]-3-(4-chlorophenyl)-4-ethynylthiophene-2-carboxylic acid
0.00098
5-[(tert-butoxycarbonyl)[[1-(4-nitrobenzyl)-1H-imidazol-5-yl]methyl]amino]-3-(4-chlorophenyl)-4-ethynylthiophene-2-carboxylic acid
Homo sapiens
-
pH 7.5, 30°C
0.00018
6-[(4-hydroxyphenyl)(1H-imidazol-1-yl)methyl]-4-phenyl-1,2-dihydroquinolin-2-ol
Homo sapiens
-
-
0.0044
acetylgliotoxin
Homo sapiens
-
-
0.0487
alphabeta-dehydrocurvularin
Homo sapiens
-
-
0.0249
andrastin A
Homo sapiens
-
-
0.0471
andrastin B
Homo sapiens
-
-
0.0133
andrastin C
Homo sapiens
-
-
0.000014
Biphenyl-3-carboxylic acid (4-cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amide
Rattus norvegicus
-
IC50: 14 nM
0.000018
Biphenyl-3-sulfonic acid (4-cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amide
Rattus norvegicus
-
IC50: 18 nM
0.0000014
BMS-214662
Homo sapiens
-
-
0.000175 - 0.00034
chaetomellic acid A
0.0168
citreohybridone A
Homo sapiens
-
-
0.0036
citreohybridone B
Homo sapiens
-
-
0.1
desloratadine
Rattus norvegicus
-
value above
0.7
di-tert-butyl 2-[(2E,6E,10E)-1,3,7-trimethyl-1-(1-methyl-1H-imidazol-2-yl)dodeca-2,6,10-trien-1-yl]butanedioate
Homo sapiens
-
30°C, pH 7.5
0.0233
econazole
Rattus norvegicus
-
-
0.000275
ED5
Aspergillus fumigatus
-
pH 7.5, 25°C
0.05
ethyl (2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-1-[2-(methylsulfanyl)ethyl]hydrazinyl)acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.0372
ethyl 3-(2,5-dimethoxyphenyl)-1,2-oxazole-5-carboxylate
Homo sapiens
pH 7.5, 30°C
0.021 - 0.031
ethyl 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylate
0.0038
ethyl 3-(4-chlorophenyl)-4-cyano-5-[(1-methylethyl)sulfanyl]thiophene-2-carboxylate
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.001 - 0.0012
ethyl 3-(4-chlorophenyl)-4-ethynyl-5-(2l5-triaz-1-en-2-yn-1-yl)thiophene-2-carboxylate
0.014 - 0.1
ethyl 3-(4-chlorophenyl)-4-ethynyl-5-[(1H-imidazol-4-ylacetyl)amino]thiophene-2-carboxylate
0.034
ethyl 3-(4-chlorophenyl)-5-([[1-(4-cyanobenzyl)-1H-imidazol-4-yl]methyl]amino)-4-ethynylthiophene-2-carboxylate
Homo sapiens
-
pH 7.5, 30°C
0.000013
ethyl 3-(4-chlorophenyl)-5-([[1-(4-cyanobenzyl)-1H-imidazol-4-yl]methyl][[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]amino)-4-ethynylthiophene-2-carboxylate
Homo sapiens
-
pH 7.5, 30°C
0.00019 - 0.0074
ethyl 4-ethynyl-5-([[1-(4-nitrobenzyl)-1H-imidazol-5-yl]methyl]amino)-3-phenylthiophene-2-carboxylate
0.0000005 - 0.0000055
ethyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate
0.00013
ethyl 5-([[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]amino)-4-ethynyl-3-phenylthiophene-2-carboxylate
Homo sapiens
-
pH 7.5, 30°C
0.00029
ethyl 5-[(tert-butoxycarbonyl)[[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]amino]-3-(4-chlorophenyl)-4-ethynylthiophene-2-carboxylate
Homo sapiens
-
pH 7.5, 30°C
0.00033
ethyl 5-[(tert-butoxycarbonyl)[[1-(4-nitrobenzyl)-1H-imidazol-4-yl]methyl]amino]-3-(4-chlorophenyl)-4-ethynylthiophene-2-carboxylate
Homo sapiens
-
pH 7.5, 30°C
0.0021
ethyl 5-[(tert-butoxycarbonyl)[[1-(4-nitrobenzyl)-1H-imidazol-5-yl]methyl]amino]-3-(4-chlorophenyl)-4-ethynylthiophene-2-carboxylate
Homo sapiens
-
pH 7.5, 30°C
0.0093 - 0.022
ethyl [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetate
0.00000086
FTI-2148
Mus musculus
-
IC50: 0.86 nM
0.0000006 - 0.000015
FTI-276
0.0011
gliotoxin
Homo sapiens
-
-
0.0473
granaticin A
Homo sapiens
-
-
0.0448
granaticin B
Homo sapiens
-
-
0.058
kurasoin A
Homo sapiens
-
-
0.065
kurasoin B
Homo sapiens
-
-
0.0000018
L-739,750
Homo sapiens
-
-
0.000002
L-788,123
Homo sapiens
-
-
0.0066
L-Cys-L-Val-L-Leu-L-Ser
Homo sapiens
-
-
0.0133
loratadine
Rattus norvegicus
-
-
0.00024
methyl (2S)-2-([(2S)-2-[(2-[[(2R)-2-amino-3-sulfanylpropyl]amino]-3-methylpentyl)oxy]-3-phenylpropanoyl]amino)-4-(methylsulfonyl)butanoate
Homo sapiens
pH and temperature not specified in the publication
0.00000029 - 0.0000027
methyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate
0.0000228
methyl N-(1-cysteinylpiperidin-4-yl)-N-(phenylcarbonyl)-L-methioninate
Rattus norvegicus
-
IC50: 22.8 nM
0.0000327
methyl N-(1-[[1-(4-cyanobenzyl)-1H-imidazol-4-yl]methyl]piperidin-4-yl)-N-(phenylcarbonyl)-L-isoleucinate
Rattus norvegicus
-
IC50: 32.7 nM
0.0000046
methyl N-(1-[[1-(4-cyanobenzyl)-1H-imidazol-4-yl]methyl]piperidin-4-yl)-N-(phenylcarbonyl)-L-methioninate
Rattus norvegicus
-
IC50: 4.6 nM
0.000022
methyl N-(1-[[1-(4-cyanobenzyl)-1H-imidazol-4-yl]methyl]piperidin-4-yl)-N-(phenylcarbonyl)-L-phenylalaninate
Rattus norvegicus
-
IC50: 22 nM
0.000022
methyl N-(1-[[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]piperidin-4-yl)-N-(phenylcarbonyl)-L-phenylalaninate
Homo sapiens
-
-
0.0000439
methyl N-(phenylcarbonyl)-N-{1-([1-[4-(trifluoromethyl)benzyl]-1H-imidazol-4-yl]methyl)piperidin-4-yl}-L-methioninate
Rattus norvegicus
-
IC50: 43.9 nM
1
methyl N-([2-[4-ethoxy-2-(ethoxycarbonyl)-4-oxobutyl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methioninate
Saccharomyces cerevisiae
-
IC50 above 1 mM, in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C
1
methyl N-([2-[5-ethoxy-3-(methoxycarbonyl)-5-oxopentyl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-isoleucyl-L-alaninate
Saccharomyces cerevisiae
-
IC50 above 1 mM, in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C
0.19
methyl N-([2-[5-ethoxy-3-(methoxycarbonyl)-5-oxopentyl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methioninate
Saccharomyces cerevisiae
-
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C
0.34
methyl N-([2-[6-ethoxy-4-(ethoxycarbonyl)-6-oxohexyl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-isoleucyl-L-alaninate
Saccharomyces cerevisiae
-
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C
0.035
methyl N-([2-[6-ethoxy-4-(ethoxycarbonyl)-6-oxohexyl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methioninate
Saccharomyces cerevisiae
-
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C
0.00068
methyl N-([5-[(tert-butoxycarbonyl)[[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]amino]-3-(4-chlorophenyl)-4-ethynylthiophen-2-yl]carbonyl)-L-methioninate
Homo sapiens
-
pH 7.5, 30°C
0.00000235
methyl N-benzyl-N-(1-[[1-(4-cyanobenzyl)-1H-imidazol-4-yl]methyl]piperidin-4-yl)-L-methioninate
Rattus norvegicus
-
IC50: 2.35 nM
0.000397
methyl N-[1-[(1-benzyl-1H-imidazol-4-yl)methyl]piperidin-4-yl]-N-(phenylcarbonyl)-L-methioninate
Rattus norvegicus
-
IC50: 397 nM
0.00046 - 0.0082
methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methioninate
0.0028 - 0.05
methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methioninate
0.05
methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methioninate
0.0017 - 0.0046
methyl N-[[3-(4-chlorophenyl)-4-ethynyl-5-(2l5-triaz-1-en-2-yn-1-yl)thiophen-2-yl]carbonyl]-L-methioninate
0.019 - 0.023
methyl N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate
0.0047 - 0.0053
methyl N-[[4-cyano-3-(3,4-dihydroxyphenyl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate
0.05
methyl N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate
0.0036 - 0.0056
methyl N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methioninate
0.05
methyl N-[[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]-L-methioninate
0.00015 - 0.015
methyl N-[[5-([[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]amino)-4-ethynyl-3-phenylthiophen-2-yl]carbonyl]-L-methioninate
0.0189
miconazole
Rattus norvegicus
-
-
0.00373
N'-[(1Z)-1-(3-hydroxy-1-oxo-1H-inden-2-yl)ethylidene]-3-(10H-phenothiazin-10-yl)propanehydrazide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0000005 - 0.000056
N-(1-benzyl-2-[(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]ethyl)-1-methyl-1H-imidazole-4-sulfonamide
0.000005 - 0.00016
N-(1-benzyl-2-[(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]ethyl)-2-methylbenzenesulfonamide
0.0009
N-([1-[(4-chlorophenyl)carbonyl]piperidin-4-yl]methyl)-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]pyridine-2-sulfonamide
Plasmodium falciparum
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100
0.00064
N-([2-[(1E,6E,10E)-4-carboxy-4-(ethoxycarbonyl)-7,11,15-trimethylhexadeca-1,6,10,14-tetraen-1-yl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methionine
Homo sapiens
-
30°C, pH 7.5
0.00024
N-([2-[(6E,10E)-4-carboxy-4-(ethoxycarbonyl)-7,11,15-trimethylhexadeca-6,10,14-trien-1-yl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methionine
Homo sapiens
-
30°C, pH 7.5
0.000112
N-([5-[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methoxybiphenyl-2-yl]carbonyl)-L-methionine
Homo sapiens
-
-
0.000075
N-([5-[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methylbiphenyl-2-yl]carbonyl)-D-methionine
Homo sapiens
-
-
0.000053
N-([5-[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methylbiphenyl-2-yl]carbonyl)-L-methionine
Homo sapiens
-
-
0.000053
N-([5-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methoxybiphenyl-2-yl]carbonyl)-D-methionine
Homo sapiens
-
-
0.000055
N-([5-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methoxybiphenyl-2-yl]carbonyl)-L-methionine
Homo sapiens
-
-
0.00005
N-([5-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methylbiphenyl-2-yl]carbonyl)-D-methionine
Homo sapiens
-
-
0.000045
N-([5-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methylbiphenyl-2-yl]carbonyl)-L-methionine
Homo sapiens
-
-
0.000005 - 0.000008
N-tert-butyl-N2-[6-cyano-1-(1-methyl-1H-imidazol-5-yl)-1,2,3,4-tetrahydroquinolin-3-yl]-N2-[(1-methyl-1H-imidazol-2-yl)sulfonyl]glycinamide
0.0008
N-tert-butyl-N2-[6-cyano-1-(1H-imidazol-4-yl)-1,2,3,4-tetrahydroquinolin-3-yl]-N2-[(1-methyl-1H-imidazol-2-yl)sulfonyl]glycinamide
Plasmodium falciparum
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100
0.000042
N-tert-butyl-N2-[6-cyano-1-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-3-yl]-N2-[(1-methyl-1H-imidazol-2-yl)sulfonyl]glycinamide
Plasmodium falciparum
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100
0.0000024
N-[(1-acetylpiperidin-4-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]pyridine-2-sulfonamide
Plasmodium falciparum
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100
0.000003 - 0.0000065
N-[(1-butanoylpiperidin-4-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]pyridine-2-sulfonamide
0.00044
N-[(3-bromonaphthalen-2-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]pyridine-2-sulfonamide
Rattus norvegicus
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100
0.843
N-[(5-[[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methoxybiphenyl-2-yl)carbonyl]-D-methionine
Homo sapiens
-
-
0.302
N-[(5-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methoxybiphenyl-2-yl)carbonyl]-D-methionine
Homo sapiens
-
-
0.151
N-[(5-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methoxybiphenyl-2-yl)carbonyl]-L-methionine
Homo sapiens
-
-
0.012
N-[(5-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methylbiphenyl-2-yl)carbonyl]-D-methionine
Homo sapiens
-
-
0.016
N-[(5-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methylbiphenyl-2-yl)carbonyl]-L-methionine
Homo sapiens
-
-
0.00001
N-[(6-chloro-2,1,3-benzothiadiazol-5-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]pyridine-2-sulfonamide
Rattus norvegicus
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100
0.000105
N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]pyridine-2-sulfonamide
Rattus norvegicus
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100
0.0000021
N-[2-([2-[(2-amino-3-sulfanylpropyl)amino]-3-methylbutyl]amino)-3-phenylpropyl]methionine
Homo sapiens
-
-
0.00000015
N-[2-([[1-(4-cyanobenzyl)-1H-imidazol-5-yl]acetyl]amino)-3-methylpentyl]-N-(naphthalen-1-ylmethyl)glycylmethionine
Homo sapiens
-
-
0.0000008
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[(1-propanoylpiperidin-4-yl)methyl]pyridine-2-sulfonamide
Plasmodium falciparum
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100
0.0000006
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(2-methylpropanoyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide
Plasmodium falciparum
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100
0.0000006 - 0.0000078
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(3,3-dimethylbutanoyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide
0.00000075
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(cyclopropylcarbonyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide
Plasmodium falciparum
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100
0.000007 - 0.000016
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(phenylcarbonyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide
0.000005
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-[4-(1H-1,2,4-triazol-1-yl)benzyl]-1H-imidazole-4-sulfonamide
Plasmodium falciparum
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100
0.0000005 - 0.0000026
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-[4-(1H-pyrazol-1-yl)benzyl]-1H-imidazole-4-sulfonamide
0.001
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)-1-methyl-1H-imidazole-4-sulfonamide
Rattus norvegicus
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100
0.0000038
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(pyridin-2-ylmethyl)pyridine-2-sulfonamide
Rattus norvegicus
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100
0.000003
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(4-phenyl-1,3-oxazol-5-yl)methyl]pyridine-2-sulfonamide
Rattus norvegicus
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100
0.0000017
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(1H-pyrrol-1-yl)ethyl]pyridine-2-sulfonamide
Rattus norvegicus
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100
0.27
N-[[2-(2,3-dicarboxypropyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-L-isoleucyl-L-alanine
Saccharomyces cerevisiae
-
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C
0.15
N-[[2-(2,3-dicarboxypropyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-L-phenylalanyl-L-methionine
Saccharomyces cerevisiae
-
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C
0.08
N-[[2-(3,4-dicarboxybutyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-L-isoleucyl-L-alanine
Saccharomyces cerevisiae
-
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C
0.4
N-[[2-(3,4-dicarboxybutyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-L-phenylalanyl-L-methionine
Saccharomyces cerevisiae
-
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C
0.08
N-[[2-(4,5-dicarboxypentyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-L-phenylalanyl-L-methionine
Saccharomyces cerevisiae
-
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C
0.18
N-[[2-(4,5-dicarboxypentyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-Lisoleucyl-L-alanine
Saccharomyces cerevisiae
-
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C
0.00023 - 0.0017
N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methionine
0.00045 - 0.0014
N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methionine
0.0019 - 0.0022
N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methionine
0.000067 - 0.00012
N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
0.0018 - 0.0033
N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-N-methyl-D-methionine
0.000042
N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
0.00014 - 0.00019
N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
0.0048 - 0.0087
N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methionine
0.0036 - 0.04
N-[[5-([[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]amino)-4-ethynyl-3-phenylthiophen-2-yl]carbonyl]-L-methionine
0.000076 - 0.0012
N2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-glutamine
0.0000285
Na-[(3S)-3-([[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl]amino)-4-phenylbutanoyl]-L-phenylalaninamide
Homo sapiens
-
-
0.0237
O-methylthysanone
Homo sapiens
-
-
0.025
penicillic acid
Homo sapiens
-
-
0.00065
pepticinnamin A
Homo sapiens
-
-
-
0.0002
pepticinnamin B
Homo sapiens
-
-
-
0.0001
pepticinnamin C
Homo sapiens
-
-
-
0.001
pepticinnamin D
Homo sapiens
-
-
-
0.0003
pepticinnamin E
Homo sapiens
-
-
0.0005
pepticinnamin F
Homo sapiens
-
-
-
0.0000009
pyridine-2-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(1-methanesulfonyl-piperidin-4-ylmethyl)-amide
Plasmodium falciparum
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100
0.0000012
pyridine-2-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-[1-(2,2-dimethylpropionyl)-piperidin-4-ylmethyl]-amide
Plasmodium falciparum
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100
0.000002
pyridine-2-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-[1-(3,3,3-trifluoropropionyl)-piperidin-4-ylmethyl]-amide
Plasmodium falciparum
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100
0.00000057 - 0.00000086
R115777
0.076
rupatadine
Rattus norvegicus
-
-
0.027
SCH-37370
Homo sapiens
-
-
0.00025
SCH-44342
Homo sapiens
-
-
0.0000019 - 0.0001
SCH-66336
0.0000078
SCH66336
Rattus norvegicus
-
IC50: 7.8 nM, selective inhibitor
0.0145
sclerotiorin
Homo sapiens
-
-
0.048
spiculisporic acid
Homo sapiens
-
-
0.3 - 0.6
tert-butyl (2Z,4E,8E)-5,9,13-trimethyl-3-(1-methyl-1H-imidazol-2-yl)tetradeca-2,4,8,12-tetraenoate
0.0000012 - 0.0037
tert-butyl 4-(3-[(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]-2-[[(1-methyl-1H-imidazol-4-yl)sulfonyl]amino]propyl)piperidine-1-carboxylate
-
0.000003 - 0.00405
tert-butyl 4-(3-[(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]-2-[[(2-methylphenyl)sulfonyl]amino]propyl)piperidine-1-carboxylate
0.000007
tert-butyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate
Rattus norvegicus
-
at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100
0.00005
tert-butyl N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(phenylcarbonyl)glycinate
Plasmodium falciparum
-
IC50 above 0.00005 mM, at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100
0.00005
tert-butyl N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(1-methyl-1H-imidazol-4-yl)carbonyl]glycinate
Plasmodium falciparum
-
IC50 above 0.00005 mM, at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100
0.00005
tert-butyl N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(5-methylisoxazol-3-yl)carbonyl]glycinate
Plasmodium falciparum
-
IC50 above 0.00005 mM, at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100
0.0122
thysanone
Homo sapiens
-
-
0.0024
tipifarnib
Aspergillus fumigatus
-
pH 7.5, 25°C
0.2
ubenimex
Rattus norvegicus
-
value above
0.0257
WS5995-C
Homo sapiens
-
-
0.0009
[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylidene]propanedioic acid
Homo sapiens
-
30°C, pH 7.5
0.00088 - 0.004
[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]propanedioic acid
0.085 - 0.2
[(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoyl]sulfamic acid
0.021
[3-(1-methyl-1H-imidazol-2-yl)propyl][(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]propanedioic acid
Homo sapiens
-
30°C, pH 7.5
0.045
[3-(4-chlorophenyl)-4-cyano-5-[(1-methylethyl)sulfanyl]thiophen-2-yl]methyl acetate
Saccharomyces cerevisiae
-
30°C, pH 7.5
0.005 - 0.01
[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy]propanedioic acid
0.06 - 0.2
[[(4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoyl]amino]propanedioic acid
0.0037 - 0.0089
[[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetic acid