2.5.1.57: N-acylneuraminate-9-phosphate synthase

This is an abbreviated version!
For detailed information about N-acylneuraminate-9-phosphate synthase, go to the full flat file.

Word Map on EC 2.5.1.57

2.5.1.57

n-acetylmannosamine

sialylation

2-keto-3-deoxy-d-glycero-d-galacto-nononic

mannac

glycoconjugates

kdn

bottleneck

glcnac

pep

cmp-sialic

mannose

n-glycans

neunacs

frugiperda

spodoptera

cmp-n-acetylneuraminic

udp-glcnac

n-acetylmannosamine-6-phosphate

udp-n-acetylglucosamine

synthesis

Reaction

Synonyms

DmSAS, EC 4.1.3.20, N-acetylneuraminate 9-phosphate synthase, N-acetylneuraminate-9-phosphate lyase, N-acetylneuraminate-9-phosphate sialic acid 9-phosphate synthase, N-acetylneuraminate-9-phosphate synthetase, N-acetylneuraminic acid 9-phosphate synthase, N-acetylneuraminic acid 9-phosphate synthetase, N-acetylneuraminic acid phosphate synthase, N-acetylneuraminic acid-9-phosphate synthase, N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating), NANS, Neu5Ac 9-phosphate synthase, Neu5Ac 9-phosphate synthetase, neu5ac-9-P synthase, neuac-9-phosphate synthase, NeuNAc phosphate synthase, NeuNAc-9-P synthase, NPS, SAS, sialic acid 9-phosphate synthase, sialic acid synthase

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.57 N-acylneuraminate-9-phosphate synthase

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Results	in table
124	AA Sequence
1	Application
1	CAS Registry Number
9	Cloned(Commentary)
1	Disease/ Diagnostics
3	General Stability
14	Inhibitors
15	KM Value [mM]
6	Localization
26	Metals/Ions
15	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
355	Organism
3	Pathway
1	PDB ID
3	pH Optimum
1	pH Range
1	pI Value
3	Protein Variants
8	Purification (Commentary)
1	Reaction
3	Reaction Type
28	Reference
50	Source Tissue
9	Specific Activity [micromol/min/mg]
7	Storage Stability
58	Substrates and Products (Substrate)
6	Subunits
27	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
7	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.5.1.57 - N-acylneuraminate-9-phosphate synthase

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5,5'-dithio-bis(2-nitrobenzoic acid)

Rattus norvegicus

637820

Ba2+

Homo sapiens

1 mM, 93% decrease of activity

671716

Ca2+

Homo sapiens

1 mM, 76% decrease of activity

671716

Co2+

Homo sapiens

1 mM, 15% decrease of activity

671716

Cu2+

Homo sapiens

1 mM, 68% decrease of activity

671716

EDTA

2 entries

Fe2+

Homo sapiens

1 mM, 79% decrease of activity

671716

Mg2+

Homo sapiens

Q9NR45

12.5 mM Mg2+ decrease the ability for N-acetylneuraminate 9-phosphate synthesis by almost half, while the 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthetic activity drops by 20%

N-ethylmaleimide

NaF

Ni2+

1 mM, 24% decrease of activity

671716

Zn2+

Homo sapiens

1 mM, 87% decrease of activity

671716