2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase

This is an abbreviated version!
For detailed information about 3-deoxy-7-phosphoheptulonate synthase, go to the full flat file.

Reaction

Synonyms

2-dehydro-3-deoxy-D-arabino-heptonate-7-phosphate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), 2-dehydro-3-deoxy-phosphoheptanoate aldolase, 2-dehydro-3-deoxy-phosphoheptonate aldolase, 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase, 3-deoxy-7-phosphoheptulonate synthase, 3-deoxy-D-arabino heptulosonate 7-phosphate synthase, 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase, 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase, 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase, 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase, 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase, 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating), aldolase, phospho-2-keto-3-deoxyheptanoate, Aro1A, Aro4, Aro4p, AroA, AroA(Q), aroF, AroFFR, AroG, D-erythrose-4-phosphate-lyase, D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), DAH7-P synthase, DAH7-P synthase (phe), DAH7P, DAH7P synthase, DAH7PS, DAHP synthase, DAHP synthase-phe, DAHP synthase-trp, DAHP synthase-tyr, DAHP(Phe), DAHPS, DAHPS(Tyr), Dax1, deoxy-D-arabino-heptulosonate-7-phosphate synthetase, DHS, DHS1, DS-Co, DS-Mn, EC 4.1.2.15, KDPH synthase, KDPH synthetase, More, mtDAH7Ps, MtDS, NCgl0950 DAHP synthase, NCgl2098 DAHP synthase, Nme-DAH7PS, OsDAHPS, PF1690, phospho-2-dehydro-3-deoxyheptonate aldolase, phospho-2-keto-3-deoxyheptanoate aldolase, Phospho-2-keto-3-deoxyheptonate aldolase, phospho-2-keto-3-deoxyheptonic aldolase, phospho-2-oxo-3-deoxyheptonate aldolase, phzC, TmaDAH7PS

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.54 3-deoxy-7-phosphoheptulonate synthase

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Results	in table
18	Activating Compound
55180	AA Sequence
9	Application
1	CAS Registry Number
34	Cloned(Commentary)
22	Crystallization (Commentary)
2	Expression
24	General Information
17	General Stability
9	IC50 Value
247	Inhibitors
26	kcat/KM [mM/s]
31	Ki Value [mM]
146	KM Value [mM]
12	Localization
95	Metals/Ions
74	Molecular Weight [Da]
41	Natural Substrates/ Products (Substrates)
475	Organism
6	Pathway
224	PDB ID
62	pH Optimum
15	pH Range
2	pH Stability
1	pI Value
69	Protein Variants
56	Purification (Commentary)
31	Reaction
3	Reaction Type
146	Reference
4	Renatured (Commentary)
24	Source Tissue
56	Specific Activity [micromol/min/mg]
7	Storage Stability
194	Substrates and Products (Substrate)
53	Subunits
126	Synonyms
1	Systematic Name
41	Temperature Optimum [°C]
4	Temperature Range [°C]
21	Temperature Stability [°C]
60	Turnover Number [1/s]

Organism

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Organism on EC 2.5.1.54 - 3-deoxy-7-phosphoheptulonate synthase

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Actinosynnema pretiosum subsp. auranticum

-

723700

O68903

UniProt

brenda

Actinosynnema pretiosum subsp. auranticum ATCC 31565

-

723700

O68903

UniProt

brenda

Aeropyrum pernix

-

721793

Q9YEJ7

UniProt

brenda

Alcaligenes faecalis

-

639745

-

-

brenda

Amycolatopsis mediterranei

2 entries

Amycolatopsis mediterranei U-32

-

639769

-

-

brenda

Amycolatopsis methanolica

wild type strain WV2 contains DS I, a leaky L-Phe-requiring auxotroph mutant strain GH141 grown under L-Phe limitation possesses additional DS II activity

639778

-

-

brenda

Arabidopsis thaliana

3 entries

Arachis hypogaea

2 entries

Bacillus sp. (in: Bacteria)

-

639791

-

-

brenda

Bacillus sp. (in: Bacteria) B-6

-

639791

-

-

brenda

Bacillus subtilis

3 entries

Bacillus subtilis 168

bifunctional enzyme, catalyzes reactions of EC 2.5.1.54 and EC 5.4.99.5

749355

P39912

UniProt

brenda

Brassica juncea

-

639786

-

-

brenda

Comamonas testosteroni

strain ATCC 17409

639759

-

-

brenda

Corynebacterium glutamicum

4 entries

Corynebacterium glutamicum ATCC 13032

gene aroF

738265

P35170

UniProt

brenda

Cupriavidus necator

2 entries

Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1

-

639745

-

-

brenda

Daucus carota

3 entries

Delftia acidovorans

2 entries

Escherichia coli

18 entries

Escherichia coli HE 401

-

639753

-

-

brenda

Escherichia coli K12

2 entries

Escherichia coli NST 37 / ATCC 31882

-

684632

-

-

brenda

Escherichia coli W3110 / ATCC 27325

-

639792

-

-

brenda

Gossypium hirsutum

cv. Jimian20, gene GhDHS1

739286

A0A0D5ZBC4

UniProt

brenda

Helicobacter pylori

-

657871

-

-

brenda

Hydrogenophaga palleronii

strain ATCC 17724

639759

-

-

brenda

Kitasatospora aureofaciens

strain Tü 24

639742, 639743

-

-

brenda

Kitasatospora aureofaciens Tu24

strain Tü 24

639742, 639743

-

-

brenda

Kluyveromyces marxianus

-

759419

-

-

brenda

Kluyveromyces marxianus CCT 7735

-

759419

-

-

brenda

Listeria monocytogenes

-

723729

-

-

brenda

Mycobacterium tuberculosis

4 entries

Mycobacterium tuberculosis H37Rv

2 entries

Neisseria meningitidis

2 entries

Neisseria meningitidis MC58

serotype B, gene aroG

739599

Q9K169

UniProt

brenda

Neurospora crassa

3 entries

Neurospora crassa 74-OR23-1A

-

639763

-

-

brenda

Neurospora crassa 74A

-

639764

-

-

brenda

Nicotiana sylvestris

cytosolic isozyme

639754, 639780

-

-

brenda

no activity in Homo sapiens

-

739599

-

-

brenda

Oryza sativa

2 entries

Petroselinum crispum

plastidic isozyme DS-Mn and cytosolic isozyme DS-Co

639773

-

-

brenda

Pisum sativum

3 entries

Porphyromonas gingivalis

-

674736

-

-

brenda

Pseudomonas aeruginosa

2 entries

Pseudomonas aeruginosa DSM 22644

-

758943

G3XCJ9

UniProt

brenda

Pyrococcus furiosus

3 entries

Saccharomyces cerevisiae

7 entries

Saccharomyces cerevisiae RH1326

-

639785

-

-

brenda

Salmonella enterica subsp. enterica serovar Typhimurium

3 entries

Salmonella enterica subsp. enterica serovar Typhimurium SG12

-

639751

-

-

brenda

Schizosaccharomyces pombe

tyrosine-sensitive isozyme

639752

-

-

brenda

Solanum tuberosum

3 entries

Spinacia oleracea

cytosolic isozyme Ds-Co

639780

-

-

brenda

Streptomyces coelicolor

2 entries

Streptomyces coelicolor A3(2)

-

639779

-

-

brenda

Streptomyces rimosus

2 entries

Thermotoga maritima

3 entries

uncultured bacterium

metagenomic library from subtropical marine mangrove sediment

758627

A0A482F152

UniProt

brenda

Vigna radiata

2 entries

Xanthobacter autotrophicus

-

639745

-

-

brenda

Xanthobacter autotrophicus 7C

-

639745

-

-

brenda

Xanthomonas campestris

2 entries

Amycolatopsis mediterranei

-

639769

-

-

brenda

Amycolatopsis mediterranei

Trp-sensitive isozyme

639769

-

-

brenda

Arabidopsis thaliana

-

639798

-

-

brenda

Arabidopsis thaliana

-

723367

P29976

UniProt

brenda

Arabidopsis thaliana

enzyme is encoded by duplicated genes : DHS1 and DHS2

639772

-

-

brenda

Arachis hypogaea

2 isozymes: DS-Co and DS-Mn

639790

-

-

brenda

Arachis hypogaea

cv. JL-24

639790

-

-

brenda

Bacillus subtilis

-

674736

-

-

brenda

Bacillus subtilis

bifunctional enzyme, catalyzes reactions of EC 2.5.1.54 and EC 5.4.99.5

749355

P39912

UniProt

brenda

Bacillus subtilis

Marburg strain and strain 168, bifunctional enzyme with chorismate mutase activity in addition to enzymic activity

657873

-

-

brenda

Corynebacterium glutamicum

-

639793

-

-

brenda

Corynebacterium glutamicum

gene aroF

738265

P35170

UniProt

brenda

Corynebacterium glutamicum

strains ATCC 13032 and RES167

684585

-

-

brenda

Corynebacterium glutamicum

Tyr-sensitive isozyme

639794

-

-

brenda

Cupriavidus necator

-

639745

-

-

brenda

Cupriavidus necator

basonym Alcaligenes eutrophus

639745

-

-

brenda

Daucus carota

3 enzymes: I, II, and II

639758

-

-

brenda

Daucus carota

cv. Kurodagosun

639765

-

-

brenda

Daucus carota

cytosolic isozyme

639765

-

-

brenda

Delftia acidovorans

i.e. Comamonas terrigena

639759

-

-

brenda

Delftia acidovorans

strain ATCC 11299a, two distinct regulatory isoenzymes: DAHP synthase-phe and DAHP synthase-tyr

639759

-

-

brenda

Escherichia coli

-

637413, 639753, 639783, 639792

-

-

brenda

Escherichia coli

-

657984

P0AB91

Swissprot

brenda

Escherichia coli

-

658128, 672576, 672596, 680370, 684632, 710184, 721804

-

-

brenda

Escherichia coli

-

723276

P0AB91

Swissprot

brenda

Escherichia coli

-

747338

P00888

SwissProt

brenda

Escherichia coli

3 isoenzymes

639775

-

-

brenda

Escherichia coli

deletion mutant strain H80c from strain HfrH

639746

-

-

brenda

Escherichia coli

gene aroG

738530, 738761

P0AB91

Swissprot

brenda

Escherichia coli

isoform AroG

659071, 659072, 659406

-

-

brenda

Escherichia coli

isoform DAHPS(Phe)

758795, 758801, 758822

C3TIE2

UniProt

brenda

Escherichia coli

isoform is Tyr-sensitive

759681

P00888

SwissProt

brenda

Escherichia coli

K12

639748, 639749, 639750, 639753, 639792

-

-

brenda

Escherichia coli

mutant 83-24

639741

-

-

brenda

Escherichia coli

Phe-sensitive isozyme

639788

P0AB91

Swissprot

brenda

Escherichia coli

phenylalanine-sensitive isozyme

637421, 639753, 639771, 639774, 639776, 639789

-

-

brenda

Escherichia coli

phenylalanine-sensitive isozyme

639796

P0AB91

Swissprot

brenda

Escherichia coli

tryptophan-sensitive isozyme

639767, 639768

-

-

brenda

Escherichia coli

tyrosine-sensitive isozyme

639746, 639747, 639777, 639792

-

-

brenda

Escherichia coli K12

-

747338

P00888

SwissProt

brenda

Escherichia coli K12

isoform is Tyr-sensitive

759681

P00888

SwissProt

brenda

Mycobacterium tuberculosis

-

701494, 703449

O53512

UniProt

brenda

Mycobacterium tuberculosis

expression in Escherichia coli

660444

-

-

brenda

Mycobacterium tuberculosis

gene aroG

738155

O53512

UniProt

brenda

Mycobacterium tuberculosis

recombinant protein, coexpression with Escherichia coli chaperonins GroEL and GroES in Escherichia coli

657484

-

-

brenda

Mycobacterium tuberculosis H37Rv

-

703449

O53512

UniProt

brenda

Mycobacterium tuberculosis H37Rv

expression in Escherichia coli

660444

-

-

brenda

Neisseria meningitidis

gene aroG

737813, 739438

Q9K169

UniProt

brenda

Neisseria meningitidis

serotype B, gene aroG

739599

Q9K169

UniProt

brenda

Neurospora crassa

-

639763, 639764

-

-

brenda

Neurospora crassa

Trp-, Phe- and Tyr-sensitive isoenzymes

639763

-

-

brenda

Neurospora crassa

tryptophan-sensitive isozyme

639762, 639764, 639779

-

-

brenda

Oryza sativa

-

676479

-

-

brenda

Oryza sativa

-

738708

Q0D4J5

UniProt

brenda

Pisum sativum

cv. Onyx

639761

-

-

brenda

Pisum sativum

cytosolic isozyme Ds-Co

639780

-

-

brenda

Pisum sativum

tyrosine-sensitive isozyme

639761

-

-

brenda

Pseudomonas aeruginosa

-

758943

G3XCJ9

UniProt

brenda

Pseudomonas aeruginosa

2 isoenzymes: tyrosine-sensitive DAHP synthase-tyr and tryptophane-sensitive DAHP synthase-trp

639760

-

-

brenda

Pyrococcus furiosus

-

658097

Q8U0A9

Uniprot

brenda

Pyrococcus furiosus

-

660428

-

-

brenda

Pyrococcus furiosus

-

725725

Q8U0A9

Uniprot

brenda

Saccharomyces cerevisiae

-

639785

-

-

brenda

Saccharomyces cerevisiae

-

659711

P32449

Uniprot

brenda

Saccharomyces cerevisiae

-

676798

-

-

brenda

Saccharomyces cerevisiae

ARO3-encoded isozyme is a phenylalanine-sensitive isozyme

639757, 639766

-

-

brenda

Saccharomyces cerevisiae

ARO4-encoded isozyme is a tyrosine-sensitive isozyme

639757, 639766, 639785

-

-

brenda

Saccharomyces cerevisiae

Phe-sensitive isozyme

639770

-

-

brenda

Saccharomyces cerevisiae

strain strain CEN.PK666-1C

688818

-

-

brenda

Salmonella enterica subsp. enterica serovar Typhimurium

-

639751

-

-

brenda

Salmonella enterica subsp. enterica serovar Typhimurium

operator-constitutive strain tyrO

639744, 639751

-

-

brenda

Salmonella enterica subsp. enterica serovar Typhimurium

tyrosine-sensitive isozyme

639744, 639751

-

-

brenda

Solanum tuberosum

-

639756, 639772

-

-

brenda

Solanum tuberosum

cv. Superior

639755

-

-

brenda

Solanum tuberosum

cytosolic isozyme Ds-Co

639780

-

-

brenda

Streptomyces coelicolor

-

639779

-

-

brenda

Streptomyces coelicolor

Trp-sensitive isozyme

639779

-

-

brenda

Streptomyces rimosus

-

639781

-

-

brenda

Streptomyces rimosus

Trp-sensitive isozyme

639779

-

-

brenda

Thermotoga maritima

-

659716

-

-

brenda

Thermotoga maritima

gene aroF

738228

Q9WYH8

UniProt

brenda

Thermotoga maritima

recombinant enzyme

659228

-

-

brenda

Vigna radiata

-

639780

-

-

brenda

Vigna radiata

2 differentially regulated isozymes: DS-Mn and DS-Co

639782

-

-

brenda

Xanthomonas campestris

2 classes of enzymes: class AroAI and AroAII

639795

-

-

brenda

Xanthomonas campestris

strain ATCC 33436

639795

-

-

brenda