2.5.1.49: O-acetylhomoserine aminocarboxypropyltransferase

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For detailed information about O-acetylhomoserine aminocarboxypropyltransferase, go to the full flat file.

Reaction

Synonyms

AHS, EC 4.2.99.10, gamma-cyano-alpha-aminobutyric acid synthase, Homocysteine synthase, MetC, methionine synthase, MetY, O-acetyl-L-homoserine (thiol)-lyase, O-acetyl-L-homoserine acetate-lyase (adding methanethiol), O-acetyl-L-homoserine sulfhydrolase, o-acetyl-L-homoserine sulfhydrylase, O-acetylhomoserine sulfhydrolase, O-acetylhomoserine sulfhydrylase, OAH, OAH SHase, OAH SHLase, OAH sulfhydrylase, OAH-OAS sulfhydrylase, oah2 gene product, OAHS, OAS-OAH sulfhydrylase, Q187D4

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase

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5	Activating Compound
11400	AA Sequence
3	Application
1	CAS Registry Number
9	Cloned(Commentary)
15	Cofactor
2	Crystallization (Commentary)
2	Disease/ Diagnostics
1	General Information
6	General Stability
2	IC50 Value
74	Inhibitors
3	kcat/KM [mM/s]
17	Ki Value [mM]
41	KM Value [mM]
2	Metals/Ions
32	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
47	Organism
7	Pathway
16	PDB ID
13	pH Optimum
4	pH Range
4	pH Stability
1	pI Value
18	Purification (Commentary)
1	Reaction
4	Reaction Type
43	Reference
16	Source Tissue
38	Specific Activity [micromol/min/mg]
6	Storage Stability
145	Substrates and Products (Substrate)
23	Subunits
51	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]
3	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.5.1.49 - O-acetylhomoserine aminocarboxypropyltransferase

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SYSTEMATIC NAME

IUBMB Comments

O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase

Also reacts with other thiols and H2S, producing homocysteine or thioethers. The name methionine synthase is more commonly applied to EC 2.1.1.13, methionine synthase. The enzyme from baker's yeast also catalyses the reaction of EC 2.5.1.47 cysteine synthase, but more slowly.