2.5.1.49: O-acetylhomoserine aminocarboxypropyltransferase
This is an abbreviated version!
For detailed information about O-acetylhomoserine aminocarboxypropyltransferase, go to the full flat file.
Word Map on EC 2.5.1.49
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2.5.1.49
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cystathionine
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o-acetylserine
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l-methionine
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4.2.99.10
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o-acetyl-l-serine
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gamma-lyase
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gamma-synthase
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l-homocysteine
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o-succinylhomoserine
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o-acetyltransferase
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beta-synthase
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beta-lyase
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medicine
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synthesis
- 2.5.1.49
- cystathionine
- o-acetylserine
- l-methionine
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4.2.99.10
- o-acetyl-l-serine
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gamma-lyase
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gamma-synthase
- l-homocysteine
- o-succinylhomoserine
- o-acetyltransferase
- beta-synthase
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beta-lyase
- medicine
- synthesis
Reaction
Synonyms
AHS, EC 4.2.99.10, gamma-cyano-alpha-aminobutyric acid synthase, Homocysteine synthase, MetC, methionine synthase, MetY, O-acetyl-L-homoserine (thiol)-lyase, O-acetyl-L-homoserine acetate-lyase (adding methanethiol), O-acetyl-L-homoserine sulfhydrolase, o-acetyl-L-homoserine sulfhydrylase, O-acetylhomoserine sulfhydrolase, O-acetylhomoserine sulfhydrylase, OAH, OAH SHase, OAH SHLase, OAH sulfhydrylase, OAH-OAS sulfhydrylase, oah2 gene product, OAHS, OAS-OAH sulfhydrylase, Q187D4
ECTree
2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 2.5.1.49 - O-acetylhomoserine aminocarboxypropyltransferase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
diethyl N-[[3-bromo-4-([[2,4-diamino-5-(2,3-dibromopropyl)-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl]methyl]amino)phenyl]carbonyl]glutamate
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inhibition of methionine synthase, arrest of cell cycle in G1/S phase and apoptosis. Treatment results in increase in cyclin E and cyclin-dependent kinase 2, reduction of caspase-3, poly(ADP-ribose) polymerase, caspase-8, and caspase-9 protein levels
L-propargylglycine
irreversible, rapid inactivation; suicide inhibitor
N-[[3-bromo-4-([[2,4-diamino-5-(2,3-dibromopropyl)-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl]methyl]amino)phenyl]carbonyl]glutamic acid
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inhibition of methionine synthase, arrest of cell cycle in G1/S phase and apoptosis. Treatment results in increase in cyclin E and cyclin-dependent kinase 2, reduction of caspase-3, poly(ADP-ribose) polymerase, caspase-8, and caspase-9 protein levels
Ngamma-acetyl-L-2,4-diaminobutyric acid
competitive; competitive and reversible inhibition
pyridoxal
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inhibits the activity competitively with respect to pyridoxal 5'-phosphate
additional information
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no sulfhydryl reagents inhibits the enzyme, S-adenosylmethionine is no inhibitor
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additional information
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no repression by S-adenosyl-L-methionine
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additional information
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no end product inhibition by methionine or S-adenosylmethionine observed
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additional information
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L-serine, glycine and L-alanine are not inhibitors, dithiothreitol and p-chloromercuribenzoate shows no inhibitory effect
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additional information
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p-chloromercuribenzoic acid, 5,5'-dithio-bis(2-nitrobenzoic acid) and monoiodoacetic acid have no inhibitory effect
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additional information
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L-serine, glycine, cystathione and S-adenosyl-L-methionine are no inhibitors
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