2.5.1.45: homospermidine synthase (spermidine-specific)

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For detailed information about homospermidine synthase (spermidine-specific), go to the full flat file.

Reaction

Synonyms

homospermidine synthase, HSS, HSS1, synthase, homospermidine, synthase, homospermidine (Senecio vernalis root gene HSS1)

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.45 homospermidine synthase (spermidine-specific)

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Results	in table
49	AA Sequence
2	CAS Registry Number
18	Cloned(Commentary)
9	Cofactor
5	Expression
23	General Information
1	General Stability
5	Inhibitors
5	Ki Value [mM]
5	KM Value [mM]
3	Localization
11	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
35	Organism
1	Pathway
1	pH Optimum
1	pH Range
7	Protein Variants
9	Purification (Commentary)
1	Reaction
1	Reaction Type
35	Reference
67	Source Tissue
7	Specific Activity [micromol/min/mg]
1	Storage Stability
36	Substrates and Products (Substrate)
10	Subunits
22	Synonyms
1	Systematic Name
1	Turnover Number [1/s]

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Reaction on EC 2.5.1.45 - homospermidine synthase (spermidine-specific)

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spermidine + putrescine = sym-homospermidine + propane-1,3-diamine

the reaction of this enzyme occurs in three steps: i. NAD-dependent dehydrogenation of spermidine, ii. transfer of the 4-aminobutylidene group from dehydrospermidine to putrescine, iii. reduction of the imine intermediate to form homospermidine. Hence the overall reaction is transfer of a 4-aminobutyl group. This enzyme is more specific than EC 2.5.1.44, homospermidine synthase, which is found in bacteria, as it cannot use putrescine as donor of the 4-aminobutyl group. Forms part of the biosynthetic pathway of the poisonous pyrrolizidine alkaloids of the ragworts, Senecio