2.5.1.43: nicotianamine synthase
This is an abbreviated version!
For detailed information about nicotianamine synthase, go to the full flat file.
Word Map on EC 2.5.1.43
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2.5.1.43
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abstinence
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infant
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opioids
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women
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nursing
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nucleostide
-
naphthenic
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nafld
-
steatohepatitis
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withdrawal
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sands
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methadone
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nonalcoholic
-
steatosis
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morphine
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services
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accumbens
-
nurses
-
entecavir
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n-acetylserotonin
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buprenorphine
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virological
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policy
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tenofovir
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hbeag
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oseltamivir
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opiate
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academy
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lamivudine
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adefovir
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zanamivir
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strictures
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hbeag-positive
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ukraine
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nonpharmacologic
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alberta
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seroconversion
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neuraminidases
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caring
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telbivudine
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mother-infant
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dipivoxil
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fe-deficient
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lilacs
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staffing
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nanoassemblies
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medicaid
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peg-ifn
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disoproxil
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hbeag-negative
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agriculture
- 2.5.1.43
-
abstinence
- infant
-
opioids
- women
-
nursing
-
nucleostide
-
naphthenic
- nafld
- steatohepatitis
- withdrawal
-
sands
- methadone
-
nonalcoholic
- steatosis
- morphine
-
services
- accumbens
- nurses
-
entecavir
- n-acetylserotonin
- buprenorphine
-
virological
-
policy
- tenofovir
-
hbeag
- oseltamivir
-
opiate
-
academy
- lamivudine
-
adefovir
- zanamivir
-
strictures
-
hbeag-positive
-
ukraine
-
nonpharmacologic
-
alberta
-
seroconversion
- neuraminidases
-
caring
-
telbivudine
-
mother-infant
-
dipivoxil
-
fe-deficient
- lilacs
-
staffing
-
nanoassemblies
-
medicaid
-
peg-ifn
-
disoproxil
-
hbeag-negative
- agriculture
Reaction
3 S-adenosyl-L-methionine
=
3 S-methyl-5'-thioadenosine
+
Synonyms
AtNAS, AtNAS1, AtNAS2, AtNAS3, AtNAS4, chloronerva, HvNAS1, HvNAS2, HvNAS3, HvNAS4, HvNAS6, HvNAS7, HvNAS8, HvNAS9, LeNAS, LjNAS1, LjNAS2, MtNAS, MxNAS2, NA synthase, NA synthase 2, NAS, NAS1, NAS2, NAS3, NAS4, NASHOR1, NASHOR2, nicotianamine synthase, nicotianamine synthase 1, nicotianamine synthase 2, nicotianamine synthase 4, OsNA S2, OsNAS1, OsNAS2, OsNAS3, S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-methionine 3-amino-3-carboxypropyltransferase, synthase, nicotianamine, TaNAS1, TaNAS1-A, TaNAS1-B, TaNAS2, TaNAS2-A, TaNAS2-D1, TaNAS2-D2, TaNAS3-A, TaNAS3-B, TaNAS4-A, TaNAS4-D, TaNAS4-U, TaNAS5-B, TaNAS6-A, TaNAS6-B, TaNAS6-D, TaNAS7-A1, TaNAS7-A2, TaNAS7-D, TaNAS9-A, TaNAS9-B, TaNAS9-D, TmNAS, TmNAS1, TmNAS2, TmNAS3, TmNAS4, TmNAS5, TmNAS6, TmNAS7, TmNAS8, ZmNAS1, ZmNAS10, ZmNAS1;1, ZmNAS1;2, ZmNAS2, ZmNAS2;1, ZmNAS2;2, ZmNAS3, ZmNAS4, ZmNAS5, ZmNAS6, ZmNAS6;1, ZmNAS6;2, ZmNAS7, ZmNAS8, ZmNAS9
ECTree
2.5.1.43 nicotianamine synthaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.5.1.43 - nicotianamine synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl-L-methionine + glutamate
2 S-methyl-5'-thioadenosine + thermoNicotianamine + 2 H+
additional information
?
-
-
the enzyme condenses three aminopropyl moieties of S-adenosylmethionine and the autocyclization of one moiety leads to the formation of an azetidine ring
-
-
?
2 S-adenosyl-L-methionine + glutamate
2 S-methyl-5'-thioadenosine + thermoNicotianamine + 2 H+
-
-
the archaeal product analogue thermoNicotianamine differs from nicotianamine in the carboxy azetidine moiety of nicotianamine that is replaced by a glutamate moiety in thermoNicotianamine, overview
-
?
2 S-adenosyl-L-methionine + glutamate
2 S-methyl-5'-thioadenosine + thermoNicotianamine + 2 H+
-
substrate binding structures, overview
the archaeal product analogue thermoNicotianamine differs from nicotianamine in the carboxy azetidine moiety of nicotianamine that is replaced by a glutamate moiety in thermoNicotianamine, overview
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
important role in production of nicotianamine under Fe-deficient conditions
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
the enzyme is required for symbiotic nitrogen fixation in Medicago truncatula nodules
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
important role in production of nicotianamine under Fe-deficient conditions
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
rice synthesizes nicotianamine with OsNAS3 under Fe excess in roots and shoots. Nicotianamine and deoxymugineic acid synthesized by OsNAS3 under excess Fe conditions contribute to Fe detoxification in rice
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
the enzyme catalyzes trimerization of S-adenosyl-L-methionine and ring formation to synthesize nicotinamine
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
3 S-adenosyl-L-methionine
3 S-methyl-5'-thioadenosine + nicotianamine
the enzyme catalyzes trimerization of S-adenosyl-L-methionine and ring formation to synthesize nicotinamine
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
the product nictotinamine plays a critical role in metal detoxification
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
nicotinamine synthase and nicotinamine play an important role in long-distance transport of Fe in rice plants, in addition to their roles in phytosiderophore secretion from roots
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
5'-S-methyl-5'-thioadenosine + nicotianamine
-
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is induced at the 3rd day after withholding Fe supply and declines within one day following the supply of Fe3+-epihydroxymugineic acid
-
-
?
S-adenosyl-L-methionine
?
-
synthesis of nicotianamide, the key precursor of the mugineic acid family phytosiderophores
-
-
?
S-adenosyl-L-methionine
?
-
key enzyme in the biosynthetic pathway for the mugineic acid family of phytosiderophores
-
-
?
S-adenosyl-L-methionine
?
-
strongly induced by Fe-deficiency treatment
-
-
?
S-adenosyl-L-methionine
?
-
enzyme in the biosynthetic pathway of mugineic acids
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is not induced by Fe-deficiency
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is not induced by Fe-deficiency
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is not induced by Fe-deficiency
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is not induced by Fe-deficiency
-
-
?
S-adenosyl-L-methionine
?
-
enzyme activity is not induced by Fe-deficiency
-
-
?
S-adenosyl-L-methionine
?
-
in agreement with the increased secretion of phytosiderophores with Fe deficiency, ZmNAS1 and ZmNAS2 are positively expressed only in Fe-deficient roots. In contrast ZmNAS3 is expressed under Fe-sufficient conditions, and is negatively regulated by Fe deficiency
-
-
?
