2.5.1.41: phosphoglycerol geranylgeranyltransferase

This is an abbreviated version!
For detailed information about phosphoglycerol geranylgeranyltransferase, go to the full flat file.

Reaction

Synonyms

((S)-GGGP) synthase, (S)-3-O-geranylgeranylglyceryl phosphate synthase, (S)-3-O-geranylgeranylglycerylphosphate, geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase, geranylgeranyl-transferase, geranylgeranylglycerol-phosphate geranylgeranyltransferase, geranylgeranylglyceryl phosphate synthase, geranylgeranyltransferase II, geranylgeranyltransferase, geranylgeranyloxyglycerol phosphate, GGGP synthase, GGGPS, glycerol phosphate feranylgeranyltransferase, prenyltransferase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.41 phosphoglycerol geranylgeranyltransferase

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Results	in table
1	Activating Compound
4456	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
3	Crystallization (Commentary)
5	General Information
1	Inhibitors
4	KM Value [mM]
2	Localization
2	Metals/Ions
3	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
41	Organism
5	Pathway
26	PDB ID
2	pH Optimum
1	pH Range
4	Purification (Commentary)
1	Reaction
1	Reaction Type
12	Reference
2	Source Tissue
12	Substrates and Products (Substrate)
6	Subunits
26	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]

Systematic Name

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Systematic Name on EC 2.5.1.41 - phosphoglycerol geranylgeranyltransferase

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SYSTEMATIC NAME

IUBMB Comments

geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase

This cytosolic enzyme catalyses the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria [2]. Requires Mg2+ for maximal activity [2]. It catalyses the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate [2]. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.42 (geranylgeranylglycerol-phosphate geranylgeranyltransferase) and EC 2.7.7.67 (CDP-archaeol synthase), which lead to the formation of CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [5].