2.5.1.31: ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]

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For detailed information about ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific], go to the full flat file.

Reaction

Synonyms

bactoprenyl-diphosphate synthase, C55-OO synthetase, C55PP synthetase, cis,polyprenyl diphosphate synthase, cis-prenyl chain elongating enzyme, cis-type undecaprenyl pyrophosphate synthase, CPDS, DDPPs, dehydrodolichyl diphosphate synthase, di-trans,poly-cis-decaprenylcistransferase, di-trans,poly-cis-undecaprenyl-diphosphate synthase, di-trans-poly-cis-decaprenyl cistransferase, isosesquilavandulyl diphosphate synthase, Mcl22, More, synthetase, undecaprenyl pyrophosphate, undecaprenyl diphosphate phosphatase, undecaprenyl diphosphate synthase, undecaprenyl diphosphate synthetase, undecaprenyl pyrophosphate synthase, undecaprenyl pyrophosphate synthetase, undecaprenyl-diphosphate synthase, undecaprenyl-pyrophosphate synthase, UPP synthase, UPP synthetase, UPP, C55 synthase, UPPs, UPS, Z-prenyl diphosphate synthase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.31 ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]

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Results	in table
65	Activating Compound
7827	AA Sequence
10	Application
1	CAS Registry Number
37	Cloned(Commentary)
21	Crystallization (Commentary)
31	General Information
2	General Stability
159	IC50 Value
212	Inhibitors
47	kcat/KM [mM/s]
17	Ki Value [mM]
387	KM Value [mM]
14	Localization
80	Metals/Ions
17	Molecular Weight [Da]
56	Natural Substrates/ Products (Substrates)
376	Organism
6	Pathway
79	PDB ID
35	pH Optimum
1	pH Range
1	pI Value
149	Protein Variants
37	Purification (Commentary)
9	Reaction
1	Reaction Type
104	Reference
1	Renatured (Commentary)
11	Specific Activity [micromol/min/mg]
2	Storage Stability
247	Substrates and Products (Substrate)
25	Subunits
173	Synonyms
1	Systematic Name
25	Temperature Optimum [°C]
1	Temperature Stability [°C]
163	Turnover Number [1/s]

KI Value

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KI Value on EC 2.5.1.31 - ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0002

(2E,6E)-farnesyl thiodiphosphate

Escherichia coli

-

pH 7.5, 25°C

637494

0.008

(2E,6E,10E)-4-methylfarnesyl diphosphate

Bacillus subtilis

-

competitive inhibitor against (2Z,6E,10E)-geranylgeranyl diphosphate, 37°C, pH 37°C

708500

0.0054 - 0.0058

(2Z,6E,10E)-4-methyl-geranylgeranyl diphosphate

2 entries

0.041 - 0.075

(E)-3-methyl-3-pentenyl diphosphate

2 entries

0.0002

(S)-farnesyl thiopyrophosphate

Escherichia coli

-

-

637494

0.017 - 0.028

3-desmethyl (2Z,6E,10E)-geranylgeranyl diphosphate

2 entries

0.045 - 2.8

3-desmethyl farnesyl diphosphate

3 entries

0.017 - 0.028

3-desmethyl Z-geranylgeranyl diphosphate

2 entries

0.00057

7-(2,6-dimethyl-8-diphospho-2,6-octadienyloxy)-8-methyl-4-trifluoromethyl-chromen-2-one geranyl diphosphate

Escherichia coli

-

(2E,6E)-farnesyl diphosphate as a substrate, pH 7.5, 25°C

708864

1.1

Mg2+

Escherichia coli

P60472

pH 7.5, 25°C

659476

17

SO42-

Micrococcus luteus

O82827

-

637492

0.0054

(2Z,6E,10E)-4-methyl-geranylgeranyl diphosphate

Bacillus subtilis

-

potent competitive inhibitor against (2Z,6E,10E)-geranylgeranyl diphosphate, 37°C, pH 37°C

708500

0.0058

(2Z,6E,10E)-4-methyl-geranylgeranyl diphosphate

Bacillus subtilis

-

noncompetitive inhibitor against isopentenyl diphosphate, 37°C, pH 37°C

708500

0.041

(E)-3-methyl-3-pentenyl diphosphate

Bacillus subtilis

-

calculated against isopentenyl diphosphate, 37°C, pH 37°C

708500

0.075

(E)-3-methyl-3-pentenyl diphosphate

Bacillus subtilis

-

calculated against (2Z,6E,10E)-geranylgeranyl diphosphate, 37°C, pH 37°C

708500

0.017

3-desmethyl (2Z,6E,10E)-geranylgeranyl diphosphate

Micrococcus luteus

-

substrate farnesyl diphosphate, pH 7.5, 37°C

685691

0.028

3-desmethyl (2Z,6E,10E)-geranylgeranyl diphosphate

Micrococcus luteus

-

substrate (Z,E,E)-geranylgeranyl diphosphate, pH 7.5, 37°C

685691

0.045

3-desmethyl farnesyl diphosphate

Micrococcus luteus

-

substrate farnesyl diphosphate, pH 7.5, 37°C

685691

2.8

3-desmethyl farnesyl diphosphate

Micrococcus luteus

-

substrate (Z,E,E)-geranylgeranyl diphosphate, pH 7.5, 37°C

685691

2.8

3-desmethyl farnesyl diphosphate

Micrococcus luteus

-

substrate (2Z,6E,10E)-geranylgeranyl diphosphate, pH 7.5, 37°C

685691

0.017

3-desmethyl Z-geranylgeranyl diphosphate

Micrococcus luteus

-

substrate farnesyl diphosphate, pH 7.5, 37°C

685691

0.028

3-desmethyl Z-geranylgeranyl diphosphate

Micrococcus luteus

-

substrate (Z,E,E)-geranylgeranyl diphosphate, pH 7.5, 37°C

685691