2.5.1.3: thiamine phosphate synthase
This is an abbreviated version!
For detailed information about thiamine phosphate synthase, go to the full flat file.
Reaction
Synonyms
2-methyl-4-amino-5-hydroxymethylpyrimidinepyrophosphate:4-methyl-5-(2'-phosphoethyl)-thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase, hydroxyethylthiazole kinase/thiamine-phosphate pyrophosphorylase, PF0544, pyrophosphorylase, thiamin phosphate, SSO2532, TH16, THI6, thiamin monophosphate pyrophosphorylase, thiamin phosphate diphosphorylase, thiamin phosphate pyrophosphorylase, thiamin phosphate synthase, thiamin-phosphate pyrophosphorylase, thiamine monophosphate pyrophosphorylase, thiamine phosphate pyrophosphorylase, thiamine phosphate synthase, thiamine-phosphate diphosphorylase, thiamine-phosphate pyrophosphorylase, thiamine-phosphate synthase, thiaminephosphate pyrophosphorylase, ThiE, ThiL, ThiN protein, TM0723, TM1872, TMP pyrophosphorylase, TMP-PPase, TMPPase, TMPS, TPS, YjbQ
ECTree
2.5.1.3 thiamine phosphate synthaseAdvanced search results
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Natural Substrates Products on EC 2.5.1.3 - thiamine phosphate synthase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate
diphosphate + ?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + (R,Z)-2-(2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate
diphosphate + thiamine phosphate + CO2
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate
diphosphate + thiamine phosphate + CO2
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole
diphosphate + thiamine phosphate
2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate
diphosphate + ?
-
involved in biosynthesis of thiamine
-
-
?
2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate
diphosphate + ?
-
expression is negatively regulated by thiamin
-
-
?
2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate
diphosphate + ?
-
involved in biosynthesis of thiamine
-
-
?
2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate
diphosphate + ?
-
the bifunctional enzyme hydroxyethylthiazole kinase/thiamine-phosphate pyrophosphorylase catalyzes two sequential steps in the synthesis of thiamin monophosphate from hydroxyethylthiazole
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + (R,Z)-2-(2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate
diphosphate + thiamine phosphate + CO2
-
the enzyme catalyzes the tautomerization and decarboxylation of the intermediate (2R,5Z)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-carboxy-4-methyl-5-[2-(phosphonooxy)ethylidene]-2,5-dihydro-1,3-thiazol-3-ium
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + (R,Z)-2-(2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate
diphosphate + thiamine phosphate + CO2
-
the enzyme catalyzes the tautomerization and decarboxylation of the intermediate (2R,5Z)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-carboxy-4-methyl-5-[2-(phosphonooxy)ethylidene]-2,5-dihydro-1,3-thiazol-3-ium
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate
diphosphate + thiamine phosphate + CO2
-
the enzyme catalyzes the decarboxylation of the intermediate 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-carboxy-4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazol-3-ium
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate
diphosphate + thiamine phosphate + CO2
-
the enzyme catalyzes the decarboxylation of the intermediate 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-carboxy-4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazol-3-ium
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
contributes significantly to the balance of thiamine compounds during seed germination
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
contributes significantly to the balance of thiamine compounds during seed germination
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
contributes significantly to the balance of thiamine compounds during seed germination
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole
thiamine monophosphate + diphosphate
-
contributes significantly to the balance of thiamine compounds during seed germination
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole
diphosphate + thiamine phosphate
thiamin biosynthesis
-
-
?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole
diphosphate + thiamine phosphate
thiamin biosynthesis
-
-
?
