2.5.1.29: geranylgeranyl diphosphate synthase
This is an abbreviated version!
For detailed information about geranylgeranyl diphosphate synthase, go to the full flat file.
Word Map on EC 2.5.1.29
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2.5.1.29
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geranylgeranylation
-
isoprenoids
-
carotenoid
-
bisphosphonates
-
prenylation
-
mevalonate
-
dimethylallyl
-
phytoene
-
prenyltransferases
-
diterpene
-
allyl
-
diterpenoids
-
isoprenylation
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lycopene
-
taxus
-
uredovora
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aspartate-rich
-
synthesis
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kaurene
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drug development
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diagnostics
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fujikuroi
-
taxadiene
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medicine
-
agriculture
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pharmacology
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nutrition
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20-carbon
-
dmapp
-
carotenogenesis
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carotenogenic
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biotechnology
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copalyl
-
food industry
- 2.5.1.29
-
geranylgeranylation
-
isoprenoids
-
carotenoid
- bisphosphonates
-
prenylation
- mevalonate
-
dimethylallyl
- phytoene
- prenyltransferases
-
diterpene
-
allyl
-
diterpenoids
-
isoprenylation
- lycopene
- taxus
- uredovora
-
aspartate-rich
- synthesis
-
kaurene
- drug development
- diagnostics
- fujikuroi
- taxadiene
- medicine
- agriculture
- pharmacology
- nutrition
-
20-carbon
-
dmapp
-
carotenogenesis
-
carotenogenic
- biotechnology
-
copalyl
- food industry
Reaction
Synonyms
At4g36810, bifunctional farnesyl/geranylgeranyl diphosphate synthase, BTS1, CcGGDPS1, CcGGDPS2, CotB1, CrtE, DR1395, EgcrtE, EuFPS1, EuFPS2, farnesyl diphosphate/geranylgeranyl diphosphate synthase, farnesyl-diphosphate/geranylgeranyldiphosphate, farnesyltransferase, FPPS/GGPPS, geranylgeranyl diphosphate synthase, geranylgeranyl diphosphate synthase 1, geranylgeranyl diphosphate synthase 11, geranylgeranyl pyrophosphate synthase, geranylgeranyl pyrophosphate synthase GACE1337, geranylgeranyl pyrophosphate synthase GGPPS1-1, geranylgeranyl pyrophosphate synthase GGPPS1-2, geranylgeranyl pyrophosphate synthetase, geranylgeranyl-PP synthetase, geranylgeranyl-pyrophosphate synthase, GGDP synthase, GGDPS, GGPP synthase, GGPP-S, GGPPase, GGPPS, GGPPS 1, GGPPS 191, GGPPS 2, GGPPS 3, GGPPS 595, GGPPS 727, GGPPS1, GGPPS11, GGPS, Ggps1, GGs1, GgsA, GgsB, GGSP1, gps, HpGGPPS, HsGGPPS, IbGGPS, IdsA, isoprenyl diphosphate synthase, leaf-specific geranylgeranyl pyrophosphate synthase, More, PaxG, PfFPPS, PfGGPPS, Saci_0092, short-chain type-III GGPP, synthetase, geranylgeranyl pyrophosphate, TgFPPS, Tk-IdsA, trans-prenyl diphosphate synthase, type II geranylgeranyl diphosphate synthase, type-III geranylgeranyl pyrophosphate synthase, type-III GGPPS
ECTree
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Reference on EC 2.5.1.29 - geranylgeranyl diphosphate synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dogbo, O.; Camara, B.
Purification of isopentenyl pyrophosphate isomerase and geranylgeranyl pyrophosphate synthase from Capsicum chromoplasts by affinity chromatography
Biochim. Biophys. Acta
920
140-148
1987
Capsicum annuum
-
Takahashi, I.; Ogura, K.
Prenyltransferases of Bacillus subtilis: undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase
J. Biochem.
92
1527-1537
1982
Bacillus subtilis
Sagami, H.; Ogura, K.
Geranylpyrophosphate synthetase-geranylgeranylpyrophosphate synthetase from Micrococcus luteus
Methods Enzymol.
110
188-192
1985
Micrococcus luteus
Sagami, H.; Ogura, K.
Geranylgeranyl pyrophosphate synthetase lacking geranyl-transferring activity from Micrococcus luteus
J. Biochem.
89
1573-1580
1981
Micrococcus luteus
Bouvier, F.; Suire, C.; d'Harlingue, A.; Backhaus, R.A.; Camara, B.
Molecular cloning of geranyl diphosphate synthase and compartmentation of monoterpene synthesis in plant cells
Plant J.
24
241-252
2000
Arabidopsis thaliana (P34802), Arabidopsis thaliana
Sagami, H.; Ishi, K.; Ogura, K.
Occurence and unusual properties of geranylgeranyl pyrophosphate synthetase of pig liver
Biochem. Int.
3
669-675
1981
Sus scrofa
-
Ogura, K.; Nishino, T.; Shinka, T.; Seto, S.
Prenyltransferases of pumpkin fruit
Methods Enzymol.
110
167-171
1985
Cucurbita pepo
-
Sagami, H.; Ishi, K.; Ogura, K.
Geranylgeranylpyrophosphate synthetase of pig liver
Methods Enzymol.
110
184-188
1985
Sus scrofa
Laferriere, A.; Beyer, P.
Purification of geranylgeranyl diphosphate synthase from Sinapis alba etioplasts
Biochim. Biophys. Acta
1077
167-172
1991
Sinapis alba
-
Sagami, H.; Korenaga, T.; Ogura, K.; Steiger, A.; Pyun, H.J.; Coates, R.M.
Studies on geranylgeranyl diphosphate synthase from rat liver: specific inhibition by 3-azageranylgeranyl diphosphate
Arch. Biochem. Biophys.
297
314-320
1992
Rattus norvegicus
Tachibana, A.; Tanaka, T.; Taniguchi, M.; Oi, S.
Purification and characterization of geranylgeranyl diphosphate synthase from methanobacterium thermoformicicum Sf-4
Biosci. Biotechnol. Biochem.
57
1129-1133
1993
Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus SF-4
Tachibana, A.; Tanaka, T.; Taniguchi, M.; Oi, S.
Potassium-stimulating mechanism of geranylgeranyl diphosphate synthase of Methanobacterium thermoformicicum SF-4
J. Biochem.
114
389-392
1993
Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus SF-4
Sagami, H.; Korenaga, T.; Ogura, K.
Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate
J. Biochem.
114
118-121
1993
Bos taurus
Wiedemann, M.; Misawa, N.; Sandmann, G.
Purification and enzymatic characterization of the geranylgeranyl pyrophosphate synthase from Erwinia uredovora after expression in Escherichia coli
Arch. Biochem. Biophys.
306
152-157
1993
Pantoea ananatis
Lütke Brinkhaus, F.; Rilling, H.C.
Purification of geranylgeranyl diphosphate synthase from Phycomyces blakesleanus
Arch. Biochem. Biophys.
266
607-612
1988
Phycomyces blakesleeanus
Shinka, T.; Ogura, K.; Seto, S.
Farnesyl pyrophosphate and geranylgeranyl pyrophosphate synthases during Cucurbito pepo germination
Phytochemistry
13
2103-2106
1974
Cucurbita pepo
-
Ogura, K.; Shinka, T.; Seto, S.
The purification and properties of geranylgeranyl pyrophosphate synthetase from pumpkin fruit
J. Biochem.
72
1101-1108
1972
Cucurbita pepo
Shinka, T.; Ogura, K.; Seto, S.
Comparative specificity of geranylgeranyl pyrophosphate synthetase of Micrococcus lysodeikticus and pumpkin
J. biochem.
78
1177-1181
1975
Cucurbita pepo, Micrococcus luteus
Sagami, H.; Morita, Y.; Ogura, K.
Purification and properties of geranylgeranyl-diphosphate synthase from bovine brain
J. Biol. Chem.
269
20561-20566
1994
Bos taurus
Ohnuma, S.i.; Hirooka, K.; Hemmi, H.; Ishida, C.; Ohto, C.; Nishino, T.
Conversion of product specificity of archaebacterial geranylgeranyl-diphosphate synthase. Identification of essential amino acid residues for chain length determination of prenyltransferase reaction
J. Biol. Chem.
271
18831-18837
1996
Sulfolobus acidocaldarius
Ohnuma, S.i.; Hemmi, H.; Koyama, T.; Ogura, K.; Nishino, T.
Recognition of allylic substrates in Sulfolobus acidocaldarius geranylgeranyl diphosphate synthase: analysis using mutated enzymes and artificial allylic substrates
J. Biochem.
123
1036-1040
1998
Sulfolobus acidocaldarius
Ohnuma, S.I.; Hirooka, K.; Ohto, C.; Nishino, T.
Conversion from archaeal geranylgeranyl diphosphate synthase to farnesyl diphosphate synthase. Two amino acids before the first aspartate-rich motif solely determine eukaryotic farnesyl diphosphate synthase activity
J. Biol. Chem.
272
5192-5198
1997
Sulfolobus acidocaldarius
Ohto, C.; Nakane, H.; Hemmi, H.; Ohnuma, S.I.; Obata, S.; Nishino, T.
Overexpression of an archaeal geranylgeranyl diphosphate synthase in Escherichia coli cells
Biosci. Biotechnol. Biochem.
62
1243-1246
1998
Sulfolobus acidocaldarius
Hefner, J.; Ketchum, R.E.B.; Croteau, R.
Cloning and functional expression of a cDNA encoding geranylgeranyl diphosphate synthase from Taxus canadensis and assessment of the role of this prenyltransferase in cells induced for Taxol production
Arch. Biochem. Biophys.
360
62-74
1998
Taxus canadensis (Q9ZPM3), Taxus canadensis
Laskaris, G.; van der Heijden, R.; Verpoorte, R.
Purification and partial characterization of geranylgeranyl diphosphate synthase, from Taxus baccata cell cultures. An enzyme that regulates taxane biosynthesis
Plant Sci.
153
97-105
2000
Ricinus communis, Taxus baccata
Szabo, C.M.; Matsumura, Y.; Fukura, S.; Martin, M.B.; Sanders, J.M.; Sengupta, S.; Cieslak, J.A.; Loftus, T.C.; Lea, C.R.; Lee, H.J.; Koohang, A.; Coates, R.M.; Sagami, H.; Oldfield, E.
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents
J. Med. Chem.
45
2185-2196
2002
Homo sapiens
Burke, C.; Croteau, R.
Geranyl diphosphate synthase from Abies grandis: cDNA isolation, functional expression, and characterization
Arch. Biochem. Biophys.
405
130-136
2002
Abies grandis (Q8W1R9), Abies grandis
Burke, C.; Croteau, R.
Interaction with the small subunit of geranyl diphosphate synthase modifies the chain length specificity of geranylgeranyl diphosphate synthase to produce geranyl diphosphate
J. Biol. Chem.
277
3141-3149
2002
Taxus canadensis, Abies grandis (Q8W1R9), Abies grandis
Takaya, A.; Zhang, Y.W.; Asawatreratanakul, K.; Wititsuwannakul, D.; Wititsuwannakul, R.; Takahashi, S.; Koyama, T.
Cloning, expression and characterization of a functional cDNA clone encoding geranylgeranyl diphosphate synthase of Hevea brasiliensis
Biochim. Biophys. Acta
1625
214-220
2003
Hevea brasiliensis (Q94ID7), Hevea brasiliensis
Kawasaki, T.; Hamano, Y.; Kuzuyama, T.; Itoh, N.; Seto, H.; Dairi, T.
Interconversion of the product specificity of type I eubacterial farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase through one amino acid substitution
J. Biochem.
133
83-91
2003
Kitasatospora griseola, Kitasatospora griseola MF730-N6
Nishio, K.; Nodake, Y.; Hamada, K.; Suto, K.; Nakagawa, N.; Kuramitsu, S.; Miura, K.
Expression, purification, crystallization and preliminary X-ray studies of geranylgeranyl diphosphate synthase from
Acta Crystallogr. Sect. D
D60
178-180
2004
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Fujiwara, S.; Yamanaka, A.; Hirooka, K.; Kobayashi, A.; Imanaka, T.; Fukusaki, E.
Temperature-dependent modulation of farnesyl diphosphate/geranylgeranyl diphosphate synthase from hyperthermophilic archaea
Biochem. Biophys. Res. Commun.
325
1066-1074
2004
Thermococcus kodakarensis (Q76CZ2), Thermococcus kodakarensis
Engprasert, S.; Taura, F.; Kawamukai, M.; Shoyama, Y.
Molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from Coleus forskohlii Briq
BMC Plant Biol.
4
18
2004
Plectranthus barbatus
Liao, Z.; Chen, M.; Gong, Y.; Guo, L.; Tan, Q.; Feng, X.; Sun, X.; Tan, F.; Tang, K.
A new geranylgeranyl diphosphate synthase gene from Ginkgo biloba, which intermediates the biosynthesis of the key precursor for ginkgolides
DNA Seq.
15
153-158
2004
Ginkgo biloba
Matsumura, Y.; Kuzuguchi, T.; Sagami, H.
Relationship between intron 4b splicing of the rat geranylgeranyl diphosphate synthase gene and the active enzyme expression level
J. Biochem.
136
301-312
2004
Rattus norvegicus (Q6F596)
Fukusaki, E.I.; Nishikawa, T.; Kato, K.; Shinmyo, A.; Hemmi, H.; Nishino, T.; Kobayashi, A.
Introduction of the archaebacterial geranylgeranyl pyrophosphate synthase gene into Chlamydomonas reinhardtii chloroplast
J. Biosci. Bioeng.
95
283-287
2003
Sulfolobus acidocaldarius
Liao, Z.; Gong, Y.; Kai, G.; Zuo, K.; Chen, M.; Tan, Q.; Wei, Y.; Guo, L.; Tan, F.; Sun, X.; Tang, K.
An intron-free methyl jasmonate inducible geranylgeranyl diphosphate synthase gene from Taxus media and its functional identification in yeast
Mol. Biol.
39
11-17
2005
Taxus x media
-
Wiemer, A.J.; Tong, H.; Swanson, K.M.; Hohl, R.J.
Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase
Biochem. Biophys. Res. Commun.
353
921-925
2007
Homo sapiens
Kloer, D.P.; Welsch, R.; Beyer, P.; Schulz, G.E.
Structure and reaction geometry of geranylgeranyl diphosphate synthase from Sinapis alba
Biochemistry
45
15197-15204
2006
Sinapis alba (Q43133), Sinapis alba
Yoshida, T.; Asanuma, M.; Grossmann, L.; Fuse, M.; Shibata, T.; Yonekawa, T.; Tanaka, T.; Ueno, K.; Yasuda, T.; Saito, Y.; Tatsuno, I.
Geranylgeranyl-pyrophosphate (GGPP) synthase is down-regulated during differentiation of osteoblastic cell line MC3T3-E1
FEBS Lett.
580
5203-5207
2006
Mus musculus
Hojo, M.; Matsumoto, T.; Miura, T.
Cloning and expression of a geranylgeranyl diphosphate synthase gene: insights into the synthesis of termite defence secretion
Insect Mol. Biol.
16
121-131
2007
Nasutitermes takasagoensis (A1IIV8), Nasutitermes takasagoensis (A1IIV9), Nasutitermes takasagoensis (A1IIW0), Nasutitermes takasagoensis
Chang, T.H.; Guo, R.T.; Ko, T.P.; Wang, A.H.; Liang, P.H.
Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination
J. Biol. Chem.
281
14991-15000
2006
Saccharomyces cerevisiae
Kavanagh, K.L.; Dunford, J.E.; Bunkoczi, G.; Russell, R.G.; Oppermann, U.
The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding
J. Biol. Chem.
281
22004-22012
2006
Homo sapiens
Cervantes-Cervantes, M.; Gallagher, C.E.; Zhu, C.; Wurtzel, E.T.
Maize cDNAs expressed in endosperm encode functional farnesyl diphosphate synthase with geranylgeranyl diphosphate synthase activity
Plant Physiol.
141
220-231
2006
Zea mays (Q548K3), Zea mays
Ament, K.; Van Schie, C.C.; Bouwmeester, H.J.; Haring, M.A.; Schuurink, R.C.
Induction of a leaf specific geranylgeranyl pyrophosphate synthase and emission of (E,E)-4,8,12-trimethyltrideca-1,3,7,11-tetraene in tomato are dependent on both jasmonic acid and salicylic acid signaling pathways
Planta
224
1197-1208
2006
Solanum lycopersicum (Q1A7S9), Solanum lycopersicum (Q1A7T0)
Guo, R.T.; Cao, R.; Liang, P.H.; Ko, T.P.; Chang, T.H.; Hudock, M.P.; Jeng, W.Y.; Chen, C.K.; Zhang, Y.; Song, Y.; Kuo, C.J.; Yin, F.; Oldfield, E.; Wang, A.H.
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc. Natl. Acad. Sci. USA
104
10022-10027
2007
Saccharomyces cerevisiae (Q12051)
Wiemer, A.J.; Yu, J.S.; Lamb, K.M.; Hohl, R.J.; Wiemer, D.F.
Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors
Bioorg. Med. Chem.
16
390-399
2008
Homo sapiens
Noike, M.; Katagiri, T.; Nakayama, T.; Koyama, T.; Nishino, T.; Hemmi, H.
The product chain length determination mechanism of type II geranylgeranyl diphosphate synthase requires subunit interaction
FEBS J.
275
3921-3933
2008
Pantoea ananatis
Miyagi, Y.; Matsumura, Y.; Sagami, H.
Human geranylgeranyl diphosphate synthase is an octamer in solution
J. Biochem.
142
377-381
2007
Homo sapiens
Matsumura, Y.; Kidokoro, T.; Miyagi, Y.; Marilingaiah, N.R.; Sagami, H.
The carboxyl-terminal region of the geranylgeranyl diphosphate synthase is indispensable for the stabilization of the region involved in substrate binding and catalysis
J. Biochem.
142
533-537
2007
Rattus norvegicus
Ling, Y.; Li, Z.H.; Miranda, K.; Oldfield, E.; Moreno, S.N.
The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates
J. Biol. Chem.
282
30804-30816
2007
Toxoplasma gondii (Q197X6), Toxoplasma gondii
K-M Chen, C.; Hudock, M.P.; Zhang, Y.; Guo, R.T.; Cao, R.; No, J.H.; Liang, P.H.; Ko, T.P.; Chang, T.H.; Chang, S.C.; Song, Y.; Axelson, J.; Kumar, A.; Wang, A.H.; Oldfield, E.
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J. Med. Chem.
51
5594-5607
2008
Homo sapiens (O95749)
Dudakovic, A.; Wiemer, A.J.; Lamb, K.M.; Vonnahme, L.A.; Dietz, S.E.; Hohl, R.J.
Inhibition of geranylgeranyl diphosphate synthase induces apoptosis through multiple mechanisms and displays synergy with inhibition of other isoprenoid biosynthetic enzymes
J. Pharmacol. Exp. Ther.
324
1028-1036
2008
Homo sapiens
Ye, Y.; Fujii, M.; Hirata, A.; Kawamukai, M.; Shimoda, C.; Nakamura, T.
Geranylgeranyl diphosphate synthase in fission yeast is a heteromer of farnesyl diphosphate synthase (FPS), Fps1, and an FPS-like protein, Spo9, essential for sporulation
Mol. Biol. Cell
18
3568-3581
2007
Schizosaccharomyces pombe (O59703), Schizosaccharomyces pombe
Pateraki, I.; Kanellis, A.K.
Isolation and functional analysis of two Cistus creticus cDNAs encoding geranylgeranyl diphosphate synthase
Phytochemistry
69
1641-1652
2008
Cistus creticus
Jassbi, A.R.; Gase, K.; Hettenhausen, C.; Schmidt, A.; Baldwin, I.T.
Silencing geranylgeranyl diphosphate synthase in Nicotiana attenuata dramatically impairs resistance to tobacco hornworm
Plant Physiol.
146
974-986
2008
Nicotiana attenuata
Cao, R.; Chen, C.K.; Guo, R.T.; Wang, A.H.; Oldfield, E.
Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases
Proteins
73
431-439
2008
Saccharomyces cerevisiae (Q12051), Saccharomyces cerevisiae
Wang, W.; Chen, M.; Yang, C.; Liu, W.; Lan, X.; Liao, Z.
The geranylgeranyl pyrophosphate synthase gene from Ginkgo biloba: Cloning, characterization and functional identification
Afr. J. Biotechnol.
8
1203-1210
2009
Ginkgo biloba (Q64KQ5)
-
Singkaravanit, S.; Kinoshita, H.; Ihara, F.; Nihira, T.
Geranylgeranyl diphosphate synthase genes in entomopathogenic fungi
Appl. Microbiol. Biotechnol.
85
1463-1472
2010
Metarhizium anisopliae (D2YZE2), Metarhizium anisopliae
Lo, C.H.; Chang, Y.H.; Wright, J.D.; Chen, S.H.; Kan, D.; Lim, C.; Liang, P.H.
Combined experimental and theoretical study of long-range interactions modulating dimerization and activity of yeast geranylgeranyl diphosphate synthase
J. Am. Chem. Soc.
131
4051-4062
2009
Saccharomyces cerevisiae (Q12051), Saccharomyces cerevisiae
Noike, M.; Katagiri, T.; Nakayama, T.; Nishino, T.; Hemmi, H.
Effect of mutagenesis at the region upstream from the G(Q/E) motif of three types of geranylgeranyl diphosphate synthase on product chain-length
J. Biosci. Bioeng.
107
235-239
2009
Saccharomyces cerevisiae, Pantoea ananatis, Sulfolobus acidocaldarius
Sitthithaworn, W.; Wungsintaweekul, J.; Sirisuntipong, T.; Charoonratana, T.; Ebizuka, Y.; De-Eknamkul, W.
Cloning and expression of 1-deoxy-d-xylulose 5-phosphate synthase cDNA from Croton stellatopilosus and expression of 2C-methyl-d-erythritol 4-phosphate synthase and geranylgeranyl diphosphate synthase, key enzymes of plaunotol biosynthesis
J. Plant Physiol.
167
292-300
2010
Croton stellatopilosus
Wang, Y.; Miao, Z.; Tang, K.
Molecular cloning and functional expression analysis of a new gene encoding geranylgeranyl diphosphate synthase from hazel (Corylus avellana L. Gasaway)
Mol. Biol. Rep.
37
3439-3444
2010
Corylus avellana (D6BCR2)
Saikia, S.; Scott, B.
Functional analysis and subcellular localization of two geranylgeranyl diphosphate synthases from Penicillium paxilli
Mol. Genet. Genomics
282
257-271
2009
Penicillium paxilli
Orlova, I.; Nagegowda, D.A.; Kish, C.M.; Gutensohn, M.; Maeda, H.; Varbanova, M.; Fridman, E.; Yamaguchi, S.; Hanada, A.; Kamiya, Y.; Krichevsky, A.; Citovsky, V.; Pichersky, E.; Dudareva, N.
The small subunit of snapdragon geranyl diphosphate synthase modifies the chain length specificity of tobacco geranylgeranyl diphosphate synthase in planta
Plant Cell
21
4002-4017
2009
Antirrhinum majus, Nicotiana tabacum
Chang, T.H.; Hsieh, F.L.; Ko, T.P.; Teng, K.H.; Liang, P.H.; Wang, A.H.
Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation
Plant Cell
22
454-467
2010
Mentha x piperita
Schmidt, A.; Waechtler, B.; Temp, U.; Krekling, T.; Seguin, A.; Gershenzon, J.
A bifunctional geranyl and geranylgeranyl diphosphate synthase is involved in terpene oleoresin formation in Picea abies
Plant Physiol.
152
639-655
2010
Picea abies (D2IT07), Picea abies
Wang, G.; Dixon, R.A.
Heterodimeric geranyl(geranyl)diphosphate synthase from hop (Humulus lupulus) and the evolution of monoterpene biosynthesis
Proc. Natl. Acad. Sci. USA
106
9914-9919
2009
Humulus lupulus (C4NAM7), Humulus lupulus (C4NAM8)
Battilana, J.; Costantini, L.; Emanuelli, F.; Sevini, F.; Segala, C.; Moser, S.; Velasco, R.; Versini, G.; Stella Grando, M.
The 1-deoxy-D: -xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevine
Theor. Appl. Genet.
118
653-669
2009
Vitis vinifera x Vitis vinifera, Vitis vinifera x Vitis riparia
Choi, H.J.; Choi, J.Y.; Cho, S.W.; Kang, D.; Han, K.O.; Kim, S.W.; Kim, S.Y.; Chung, Y.S.; Shin, C.S.
Genetic polymorphism of geranylgeranyl diphosphate synthase (GGSP1) predicts bone density response to bisphosphonate therapy in Korean women
Yonsei Med. J.
51
231-238
2010
Homo sapiens
Lin, J.; Jin, Y.; Zhou, X.; Wang, J.
Molecular cloning and functional analysis of the gene encoding geranylgeranyl diphosphate synthase from Jatropha curcas
Afr. J. Biotechnol.
9
3342-3351
2010
Jatropha curcas (D4P8I4)
Hojo, M.; Toga, K.; Watanabe, D.; Yamamoto, T.; Maekawa, K.
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Eucommia ulmoides (Q94IE8), Eucommia ulmoides (Q94IE9), Eucommia ulmoides
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Homo sapiens (O95749)
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Structural characterization of geranylgeranyl pyrophosphate synthase GACE1337 from the hyperthermophilic archaeon Geoglobus acetivorans
Extremophiles
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Geoglobus acetivorans (A0A0A7GEY4), Geoglobus acetivorans
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Characterization of the geranylgeranyl diphosphate synthase gene in Acyrthosiphon pisum (Hemiptera Aphididae) and its association with carotenoid biosynthesis
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Acyrthosiphon pisum
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Homo sapiens (O95749), Homo sapiens
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Unraveling the prenylation-cancer paradox in multiple myeloma with novel geranylgeranyl pyrophosphate synthase (GGPPS) inhibitors
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Homo sapiens (O95749)
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Farnesyl pyrophosphate synthase as a target for drug development discovery of natural-product-derived inhibitors and their activity in pancreatic cancer cells
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Homo sapiens (O95749)
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In vivo evaluation of isoprenoid triazole bisphosphonate inhibitors of geranylgeranyl diphosphate synthase impact of olefin stereochemistry on toxicity and biodistribution
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Mus musculus (Q9WTN0)
Huang, D.; Liu, W.; Li, A.; Wang, C.; Hu, Z.
Discovery of geranylgeranyl pyrophosphate synthase (GGPPS) paralogs from Haematococcus pluvialis based on iso-seq analysis and their function on astaxanthin biosynthesis
Mar. Drugs
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Haematococcus lacustris (A0A6B9QI74), Haematococcus lacustris (A0A6B9QIY8)
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A Simple In vitro assay to measure the activity of geranylgeranyl diphosphate synthase and other short-chain prenyltransferases
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Arabidopsis thaliana (P34802), Arabidopsis thaliana
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Metal coordination is crucial for geranylgeranyl diphosphate synthase-bisphosphonate interactions a crystallographic and computational analysis
Mol. Pharmacol.
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Homo sapiens (O95749), Homo sapiens
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