2.5.1.22: spermine synthase

This is an abbreviated version!
For detailed information about spermine synthase, go to the full flat file.

Word Map on EC 2.5.1.22

2.5.1.22

polyamine

putrescine

s-adenosylmethionine

ornithine

aminopropyltransferases

snyder-robinson

alpha-difluoromethylornithine

acaulis5

thermospermine

trans-4-methylcyclohexylamine

gyro

kyphoscoliosis

agriculture

adometdc

2.5.1.16

medicine

Reaction

S-adenosyl 3-(methylsulfanyl)propylamine

+

spermidine

=

S-methyl-5'-thioadenosine

+

spermine

Synonyms

ACL5, aminopropyltransferase, spermidine, OsSPMS1, SMS, spermidine aminopropyltransferase, spermine synthase, spermine synthase 1, spermine synthetase, Spm synthase, SpmS, SPMS1, SpmSyn, synthase, spermine

ECTree

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.22 spermine synthase

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Results	in table
1	Activating Compound
42	AA Sequence
5	Application
1	CAS Registry Number
12	Cloned(Commentary)
2	Cofactor
3	Crystallization (Commentary)
122	Disease/ Diagnostics
5	Expression
14	General Information
1	General Stability
4	IC50 Value
66	Inhibitors
7	Ki Value [mM]
23	KM Value [mM]
8	Localization
2	Metals/Ions
10	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
550	Organism
8	Pathway
14	PDB ID
6	pH Optimum
36	Protein Variants
11	Purification (Commentary)
2	Reaction
2	Reaction Type
56	Reference
65	Source Tissue
14	Specific Activity [micromol/min/mg]
1	Storage Stability
51	Substrates and Products (Substrate)
15	Subunits
37	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
10	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.5.1.22 - spermine synthase

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1,3-diaminopropane

Rattus norvegicus

-

-

1,8-diaminooctane

Rattus norvegicus

-

-

1,9-diamino-4-azanonane

Rattus norvegicus

-

weak

1,9-Diamino-5-azanonane

Rattus norvegicus

-

weak

1-aminooxy-3-N-(3-aminopropyl)-aminopropane

-

competitive inhibitor

1-aminooxy-3-N-[3-aminopropyl]-aminopropane

-

aminooxy analogue of spermidine, kinetics

3,3'-Diaminodipropylamine

Rattus norvegicus

-

weak

3-(RS)-(5'-deoxy-5'-carbaadenos-6'-yl)spermidine

-

IC50: 750 nM

5'-ethylthioadenosine

show

5'-methylthioadenosine

show

5'-methylthiotubercidin

Rattus norvegicus

-

strong, in vivo and in vitro, kinetics

5-[5'-deoxy-5'-(C)-4',5'-didehydroadenosyl]-L-ornithine

Rattus norvegicus

-

i.e. compound A9154C, prostate

7,7-Difluorospermidine

show

7-Monofluorospermidine

show

N-(3-aminopropyl)cyclohexylamine

show

N-butyl-1,3-diaminopropane

-

IC50: 0.4 mM

N-ethylmaleimide

-

in the absence of sulfhydryl compounds

N-[(2-aminooxyethyl)-1,4-diaminobutane]

-

competitive inhibitor

N-[2-aminooxyethyl]-1,4-diaminobutane

-

aminooxy analogue of spermidine, kinetics

PCMB

-

in the absence of sulfhydryl compounds

putrescine

show

S-5'-Deoxyadenosyl-(5')-1-methyl-3-(methylthio)propylamine

Rattus norvegicus

-

-

S-adenosyl-1,12-diamino-3-thio-9-azadodecane

-

IC50: 20 nM

S-Adenosyl-1,8-diamino-3-thiooctane

Rattus norvegicus

-

weak, prostate

S-Adenosyl-4-methylthiobutyrate

show

S-Adenosyl-4-thiobutyrate methylester

Rattus norvegicus

-

prostate

S-adenosyl-D-methionine

show

S-adenosyl-L-ethionine

Rattus norvegicus

-

70-98% inhibition at 1 mm

S-adenosyl-L-homocysteine

show

S-adenosyl-L-methionine

show

S-Tubercidinylmethionine

Rattus norvegicus

-

70-98% inhibition at 1 mm

spermine

show

additional information

show

-

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Release 2023.1 (January 2023)