2.5.1.22: spermine synthase

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For detailed information about spermine synthase, go to the full flat file.

Reaction

Synonyms

ACL5, aminopropyltransferase, spermidine, OsSPMS1, SMS, spermidine aminopropyltransferase, spermine synthase, spermine synthase 1, spermine synthetase, Spm synthase, SpmS, SPMS1, SpmSyn, synthase, spermine

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.22 spermine synthase

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Results	in table
1	Activating Compound
42	AA Sequence
5	Application
1	CAS Registry Number
12	Cloned(Commentary)
2	Cofactor
3	Crystallization (Commentary)
122	Disease/ Diagnostics
5	Expression
14	General Information
1	General Stability
4	IC50 Value
66	Inhibitors
7	Ki Value [mM]
23	KM Value [mM]
8	Localization
2	Metals/Ions
10	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
550	Organism
8	Pathway
14	PDB ID
6	pH Optimum
36	Protein Variants
11	Purification (Commentary)
2	Reaction
2	Reaction Type
56	Reference
65	Source Tissue
14	Specific Activity [micromol/min/mg]
1	Storage Stability
51	Substrates and Products (Substrate)
15	Subunits
37	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
10	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.5.1.22 - spermine synthase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00075

3-(RS)-(5'-deoxy-5'-carbaadenos-6'-yl)spermidine

Mus musculus

-

IC50: 750 nM

674358

0.2

N-(3-aminopropyl)cyclohexylamine

Mus musculus

-

IC50: 0.2 mM

674358

0.4

N-butyl-1,3-diaminopropane

Mus musculus

-

IC50: 0.4 mM

674358

0.00002

S-adenosyl-1,12-diamino-3-thio-9-azadodecane

Mus musculus

-

IC50: 20 nM

674358