2.5.1.22: spermine synthase

This is an abbreviated version!
For detailed information about spermine synthase, go to the full flat file.

Reaction

Synonyms

ACL5, aminopropyltransferase, spermidine, OsSPMS1, SMS, spermidine aminopropyltransferase, spermine synthase, spermine synthase 1, spermine synthetase, Spm synthase, SpmS, SPMS1, SpmSyn, synthase, spermine

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.22 spermine synthase

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Results	in table
1	Activating Compound
42	AA Sequence
5	Application
1	CAS Registry Number
12	Cloned(Commentary)
2	Cofactor
3	Crystallization (Commentary)
122	Disease/ Diagnostics
5	Expression
14	General Information
1	General Stability
4	IC50 Value
66	Inhibitors
7	Ki Value [mM]
23	KM Value [mM]
8	Localization
2	Metals/Ions
10	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
550	Organism
8	Pathway
14	PDB ID
6	pH Optimum
36	Protein Variants
11	Purification (Commentary)
2	Reaction
2	Reaction Type
56	Reference
65	Source Tissue
14	Specific Activity [micromol/min/mg]
1	Storage Stability
51	Substrates and Products (Substrate)
15	Subunits
37	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
10	Turnover Number [1/s]

General Information

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General Information on EC 2.5.1.22 - spermine synthase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

drug target

Homo sapiens

P52788

spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression. Combined inhibition of spermine synthase and MYC signaling may be an effective therapy for colorectal cancer

759826

malfunction

6 entries

metabolism

2 entries

physiological function

5 entries

malfunction

Homo sapiens

-

cells derived from patients with Snyder-Robinson syndrome, a rare X-linked recessive human disease caused by SMS gene mutations that greatly reduce the content of spermine synthase, show an increase in decarboxylated S-adenosylmethionine

721528

malfunction

Mus musculus

-

in Gy mice, which lack spermine synthase activity, the content of dcAdoMet is significantly increased by 10-30fold in liver, brain and kidney and by 150fold in heart. Transgenic expression of spermine synthase in the Gy mice reverses all of the increases in dcAdoMet content and AdoMetDC, phenotypes, overview

721528

malfunction

Homo sapiens

P52788

SMS single missense mutations cause the Snyder-Robinson Syndrome, SRS. Concerning mutability depending on structural micro-environment and involvement in the function and structural integrity of the SMS, the I150 site does not tolerate any mutation, while V132, despite its key position at the interface of SMS dimer, is quite mutable. The G56 site is still quite sensitive to charge residue replacement

723531

malfunction

Arabidopsis thaliana

-

spermine and thermospermine synthesis mutants accumulate more Na+ and show decreased survival under salt stress compared to wild-type plants

723483

malfunction

Homo sapiens

P52788

mutations in the spermine synthase gene are associated with Snyder Robinson mental retardation syndrome

758946

malfunction

Oryza sativa

-

OsSPMS1 knockout mutant show an increase in grain yield per plant in a high-yield variety, Suken118 suggesting that OsSPMS1 is an important target for yield enhancement in rice

759983

metabolism

Homo sapiens

P52788

spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression

759826

metabolism

Homo sapiens

P52788

the enzyme is critical for maintaining the balance of spermine/spermidine in the cell

759684

physiological function

Homo sapiens

-

inverse relationship between the amount of spermine synthase protein and the content of decarboxylated S-adenosylmethionine. In mice lacking spermine synthase occurs a large increase in decarboxylated S-adenosylmethionine, dcAdoMet, overexpression of human spermine synthase reduces the amount of this nucleoside, Content of AdoMet and dcAdoMet in cultured lymphoblasts from control and Snyder-Robinson syndrome patients

721528

physiological function

Arabidopsis thaliana

-

spermine accumulation is involved in long-term salt stress. Induction of polyamine metabolism is a SOS-independent response to salinity

723483

physiological function

Homo sapiens

P52788

spermine synthase is a key enzyme controlling the concentration of spermidine and spermine in the cell

723531

physiological function

Camellia sinensis

A0A0E3DGE7

the enzyme exerts a positive effect on antioxidant systems

737476

physiological function

Oryza sativa

-

the enzyme (OsSPMS1) negatively regulates seed germination, grain size, and grain yield per plant. OsSPMS1 affects ethylene synthesis and may regulate seed germination and plant growth by affecting the 1-aminocyclopropane-1-carboxylic acid and ethylene pathways

759983