2.5.1.22: spermine synthase

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For detailed information about spermine synthase, go to the full flat file.

Reaction

Synonyms

ACL5, aminopropyltransferase, spermidine, OsSPMS1, SMS, spermidine aminopropyltransferase, spermine synthase, spermine synthase 1, spermine synthetase, Spm synthase, SpmS, SPMS1, SpmSyn, synthase, spermine

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.22 spermine synthase

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Results	in table
1	Activating Compound
42	AA Sequence
5	Application
1	CAS Registry Number
12	Cloned(Commentary)
2	Cofactor
3	Crystallization (Commentary)
122	Disease/ Diagnostics
5	Expression
14	General Information
1	General Stability
4	IC50 Value
66	Inhibitors
7	Ki Value [mM]
23	KM Value [mM]
8	Localization
2	Metals/Ions
10	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
550	Organism
8	Pathway
14	PDB ID
6	pH Optimum
36	Protein Variants
11	Purification (Commentary)
2	Reaction
2	Reaction Type
56	Reference
65	Source Tissue
14	Specific Activity [micromol/min/mg]
1	Storage Stability
51	Substrates and Products (Substrate)
15	Subunits
37	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
10	Turnover Number [1/s]

Expression

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Expression on EC 2.5.1.22 - spermine synthase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

gene AtSPMS is inducible by acute salt stress and abscisic acid

Arabidopsis thaliana

-

723483

knockdown of the MYO5A gene reduces the expression of mRNA coding for spermine synthase. The amount of this transcript is also reduced in cells derived from a patient with Griscelli syndrome type 1. This suggests that, in addition to a direct physical interaction between the two proteins, myosin Va also modulates the transcription of the spermine synthase gene

Homo sapiens

P52788

758946

MYO5A knockdown decreases the expression of spermine synthase gene and renders the distribution of spermine synthase protein diffuse, supporting a role for MyoVa in spermine synthase expression and targeting

Homo sapiens

P52788

758944

spermine synthase is overexpressed in colorectal cancer

Homo sapiens

P52788

759826

the gene expression is quickly induced by cold stress

Camellia sinensis

A0A0E3DGE7

737476