2.5.1.22: spermine synthase
This is an abbreviated version!
For detailed information about spermine synthase, go to the full flat file.
Word Map on EC 2.5.1.22
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2.5.1.22
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polyamine
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putrescine
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s-adenosylmethionine
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ornithine
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aminopropyltransferases
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snyder-robinson
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alpha-difluoromethylornithine
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acaulis5
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thermospermine
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trans-4-methylcyclohexylamine
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gyro
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kyphoscoliosis
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agriculture
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adometdc
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2.5.1.16
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medicine
- 2.5.1.22
- polyamine
- putrescine
- s-adenosylmethionine
- ornithine
- aminopropyltransferases
-
snyder-robinson
- alpha-difluoromethylornithine
- acaulis5
- thermospermine
- trans-4-methylcyclohexylamine
-
gyro
-
kyphoscoliosis
- agriculture
- adometdc
-
2.5.1.16
- medicine
Reaction
Synonyms
ACL5, aminopropyltransferase, spermidine, OsSPMS1, SMS, spermidine aminopropyltransferase, spermine synthase, spermine synthase 1, spermine synthetase, Spm synthase, SpmS, SPMS1, SpmSyn, synthase, spermine
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Application
Application on EC 2.5.1.22 - spermine synthase
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agriculture
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OsSPMS1 knockout mutant show an increase in grain yield per plant in a high-yield variety, Suken118 suggesting that OsSPMS1 is an important target for yield enhancement in rice
medicine
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specific and marked decrease in spermine after diet containing N-(3-aminopropyl)cyclohexylamine
medicine
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enzyme null mutant, lack of spermine increases sensitivity of cells to anti-tumor agents
medicine
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mutation p.G56S in the N-terminal region of spermine synthase greatly reduces spermine synthase activity and leads to severe epilepsy and cognitive impairment related to Snyder-Robinson X-linked recessive mental retardation syndrome
medicine
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Snyder-Robinson syndrome (SRS) mutations drastically reduce spermine synthase activity and cause mild-to-moderate mental retardation, and may lead to a variety of other characteristics including a marfanoid habitus, skeletal defects, osteoporosis, and facial asymmetry, as well as hypotonia and movement disorders