2.5.1.21: squalene synthase
This is an abbreviated version!
For detailed information about squalene synthase, go to the full flat file.
Word Map on EC 2.5.1.21
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2.5.1.21
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farnesylation
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cholesterol
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prenylation
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sterol
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ftase
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mevalonate
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geranylgeranylation
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isoprenoids
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leukemia
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geranylgeranyltransferase
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pyrophosphate
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tipifarnib
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hmg-coa
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statin
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h-ras
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peptidomimetic
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epoxidase
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prenyltransferase
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dolichols
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rhob
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isoprenylation
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triterpene
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farnesol
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3-hydroxy-3-methylglutaryl
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lamins
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ergosterol
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cholesterol-lowering
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hmgcr
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prelamin
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p21ras
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lovastatin
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hutchinson-gilford
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lanosterol
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manumycin
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triterpenoids
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synthesis
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progerin
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farnesylpyrophosphate
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cis-prenyltransferase
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drug development
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oxidosqualene
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ras-transformed
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medicine
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ras-dependent
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nonsterols
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ras-mediated
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withanolides
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srebp-2
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ganoderic
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agriculture
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geranylgeraniol
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industry
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cycloartenol
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non-thiol
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2,3-oxidosqualene
- 2.5.1.21
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farnesylation
- cholesterol
-
prenylation
- sterol
- ftase
- mevalonate
-
geranylgeranylation
-
isoprenoids
- leukemia
-
geranylgeranyltransferase
- pyrophosphate
- tipifarnib
- hmg-coa
- statin
- h-ras
-
peptidomimetic
-
epoxidase
- prenyltransferase
- dolichols
- rhob
-
isoprenylation
-
triterpene
- farnesol
-
3-hydroxy-3-methylglutaryl
- lamins
- ergosterol
-
cholesterol-lowering
- hmgcr
-
prelamin
-
p21ras
- lovastatin
-
hutchinson-gilford
- lanosterol
- manumycin
-
triterpenoids
- synthesis
-
progerin
-
farnesylpyrophosphate
- cis-prenyltransferase
- drug development
- oxidosqualene
-
ras-transformed
- medicine
-
ras-dependent
-
nonsterols
-
ras-mediated
-
withanolides
- srebp-2
-
ganoderic
- agriculture
- geranylgeraniol
- industry
- cycloartenol
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non-thiol
- 2,3-oxidosqualene
Reaction
2 (2E,6E)-farnesyl diphosphate + + = + 2 diphosphate +
Synonyms
BbSS, BSS, CrSQS, dt-ySQase, Erg9, EtSS, farnesyl-diphosphate farnesyltransferase, farnesyl-diphosphate:farnesyldiphosphate farnesyltransferase, farnesyldiphosphate farnesyltransferase 1, farnesyldiphosphate:farnesyldiphosphate farnesyltransferase, farnesyltransferase, FDFT1, hSQS, presqualene synthase, presqualene-diphosphate synthase, SgSQS, SQase, SQS, SQS1, SQS2, squalene synthase, squalene synthase 1, squalene synthase 2, squalene synthetase, SS1, SSase, SSN, synthase, squalene, TkSQS1, TkSQS2
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Application
Application on EC 2.5.1.21 - squalene synthase
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agriculture
drug development
industry
medicine
synthesis
LdSSN is a potential drug target for visceral leishmaniasis
drug development
enzyme SQS is a potential target for antiviral strategies against hepatitis C virus
drug development
the enzyme is a target for development of next-generation hypocholesterolemia drugs
drug development
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LdSSN is a potential drug target for visceral leishmaniasis
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Thermosynechococcus vestitus
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squalene has industrial value as a lubricant, health promoting agent, and/or drop-in biofuel, establishment of an efficient Escherichia coli-based system for squalene production
industry
squalene has industrial value as a lubricant, health promoting agent, and/or drop-in biofuel, establishment of an efficient Escherichia coli-based system for squalene production
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induction of enzyme by a diet containing fluvastatin and cholestyramine
medicine
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enzyme may be important during response to infection and inflammation
medicine
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enzyme may be important during response to infection and inflammation
medicine
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1-allyl-2-[3-(benzylamino)propoxy]-9H-carbazole shows 50% inhibition of enzyme at 63 nM, significant reduction of both plasma cholesterol and plasma triglyceride levels following oral dosing
medicine
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single nuceotide polymorphism K45R, i.e. rs11549147:A>G is associated with increased total cholesterol and non-high-density lipoprotein cholesterol. Mutation also influences low-density lipolrotein cholesterol and triglycerides
medicine
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attractive target for pharmaceutical discovery in treatment of hypercholestermiae
medicine
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squalene synthase is a potential target for antilipogenic and antiinfective therapies
the engineered enzym emutant mMaSQS?C17 (E186K) is a potential candidate of the terpenes and steroids synthesis employed for synthetic biology
synthesis
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the engineered enzym emutant mMaSQS?C17 (E186K) is a potential candidate of the terpenes and steroids synthesis employed for synthetic biology
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