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2.5.1.2: thiamine pyridinylase

This is an abbreviated version!
For detailed information about thiamine pyridinylase, go to the full flat file.

Word Map on EC 2.5.1.2

Reaction

thiamine
+
Pyridine
=
1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium
+
4-methyl-5-(2-hydroxyethyl)thiazole

Synonyms

pyrimidine transferase, thiamin hydrolase, thiamin pyridinolase, thiamin pyridinylase, thiaminase, thiaminase I, thiamine pyridinolase, thiamine pyridinylase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.2 thiamine pyridinylase

KM Value

KM Value on EC 2.5.1.2 - thiamine pyridinylase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
12.5
2-aminopyridine
-
-
4.2
2-hydroxyaniline
-
-
2.9
3-aminopyridine
-
-
2.8
3-hydroxyaniline
-
-
50
3-nitroaniline
-
-
15.4
4-aminopyridine
-
-
20
4-Hydroxyaniline
-
-
0.0364
4-nitrothiophenolate
38
6-aminohexanoic acid
-
-
9.5
adenine
-
-
3.3
alpha-picoline
-
-
21.2
alpha-picolinic acid
-
-
1.4 - 5.1
aniline
0.5
beta-picoline
-
-
25
beta-picolinic acid
-
-
0.9
gamma-Picoline
-
-
3.4
gamma-picolinic acid
-
-
400
hydroxyproline
-
-
125
imidazole
-
-
33
L-cysteine
-
-
37
m-aminobenzoic acid
-
-
1.7
m-phenylene diamine
-
-
2.4
m-Toluidine
-
-
32
methylamine
-
-
0.9 - 55
nicotinic acid
37
o-aminobenzoic acid
-
-
5
o-mercaptobenzoic acid
-
best cosubstrate
1.7
o-phenylene diamine
-
-
6.4
o-toluidine
-
-
200
p-Aminobenzoic acid
-
-
3.3
p-phenylene diamine
-
-
111
proline
-
-
0.7 - 5
Pyridine
3.3
Quinoline
-
-
77
sulfanilamide
-
-
50
Sulfanilic acid
-
-
0.003 - 3.5
thiamine