2.5.1.2: thiamine pyridinylase

This is an abbreviated version!
For detailed information about thiamine pyridinylase, go to the full flat file.

Reaction

Synonyms

pyrimidine transferase, thiamin hydrolase, thiamin pyridinolase, thiamin pyridinylase, thiaminase, thiaminase I, thiamine pyridinolase, thiamine pyridinylase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.2 thiamine pyridinylase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
50	Activating Compound
111	AA Sequence
13	Application
1	CAS Registry Number
2	Cloned(Commentary)
2	Crystallization (Commentary)
21	General Information
62	Inhibitors
8	kcat/KM [mM/s]
2	Ki Value [mM]
62	KM Value [mM]
12	Localization
2	Metals/Ions
9	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
121	Organism
1	Oxidation Stability
2	Pathway
24	PDB ID
19	pH Optimum
5	pH Range
9	pH Stability
1	pI Value
7	Protein Variants
9	Purification (Commentary)
1	Reaction
1	Reaction Type
117	Reference
130	Source Tissue
4	Specific Activity [micromol/min/mg]
105	Substrates and Products (Substrate)
3	Subunits
28	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
17	Temperature Range [°C]
10	Turnover Number [1/s]

Engineering

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Engineering on EC 2.5.1.2 - thiamine pyridinylase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Protein Variants Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

C143S

Clostridium botulinum

-

inactive

737686

D302N

Clostridium botulinum

-

about 20fold decrease in kcat/Km value

737686

D94N

Clostridium botulinum

-

about 10000fold decrease in kcat/Km value

737686

E271Q

Clostridium botulinum

-

about 3000fold decrease in kcat/Km value

737686

Y46F

Clostridium botulinum

-

about 2fold decrease in kcat/Km value

737686

Y80F

Clostridium botulinum

-

about 1000fold decrease in kcat/Km value

737686

C113S

Paenibacillus thiaminolyticus

P45741

inactive mutant at the active nucleophilic site

636853