2.5.1.17: corrinoid adenosyltransferase
This is an abbreviated version!
For detailed information about corrinoid adenosyltransferase, go to the full flat file.
Word Map on EC 2.5.1.17
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2.5.1.17
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adenosylcobalamin
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cobialamin
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enterica
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adenosylation
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atp:cobialamin
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adocbl
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atp:coirrinoid
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corrinoids
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four-coordinate
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1,2-propanediol
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reuteri
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acats
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supernucleophilic
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cobinamide
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b12-dependent
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adenosylcobinamide
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5\'-deoxyadenosyl
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cyanocobalamin
-
medicine
- 2.5.1.17
- adenosylcobalamin
-
cobialamin
- enterica
-
adenosylation
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atp:cobialamin
-
adocbl
-
atp:coirrinoid
- corrinoids
-
four-coordinate
- 1,2-propanediol
- reuteri
-
acats
-
supernucleophilic
- cobinamide
-
b12-dependent
- adenosylcobinamide
-
5\'-deoxyadenosyl
- cyanocobalamin
- medicine
Reaction
2 ATP
+
2 cob(II)alamin
+
Synonyms
ACAT, adenosyltransferase, vitamin B12s, aquacob(I)alamin adenosyltransferase, aquocob(I)alamin adenosyltransferase, ATP: cobalamin adenosyltransferase, ATP:co(I)rrinoid adenosyltransferase, ATP:cob(I)alamin adenosyltransferase, ATP:cob(I)alamin Cobeta-adenosyltransferase, ATP:cob(I)alamin transferase (ATR), ATP:Cob(I)alaminadenosyltransferase, ATP:cobalamin adenosyltransferase, ATP:cobalt(I) corrinoid adenosyltransferase, ATP:corrinoid adenosyltransferase, ATP:corrinoid adenosyltransferase PduO, ATR, cob(I)alamin adenosyltransferase, cob(I)yrinic acid a,c-diamide adenosyltransferase, CobA, CobA-type ATP:Co(I)rrinoid adenosyltransferase, cobalamin adenosyltransferase, CobAMm, cobO mutant SVQ336, cobO mutant SVQ524, cobO mutantSVQ336, EC 1.16.8.1, EutT, EutT adenosyltransferase, hATR, homologeous to PduO-type ATP: cob(I)alamin adenosyltransferase, human adenosyltransferase, human ATP: cob(I)alamin adenosyltransferase, human-type ACA, human-type ATP: co(I)rrinoid adenosyltransferase, human-type ATP: cob(I)alamin adenosyltransferase, LrPduO, methylmalonic aciduria type B, MMAB, MMAB protein, PduO, PduO adenosyltransferase, PduO enzyme, PduO protein, PduO-type ACA, PduO-type adenosine 5'-triphosphate:corrinoid adenosyltransferase, PduO-type ATP: cobalamin adenosyltransferase, PduO-type ATP:Co(I)rrinoid adenosyltransferase, PduO-type ATP:cob(I)alamin adenosyltransferase, PduO-type ATP:corrinoid adenosyltransferase, PduO-type corrinoid adenosyltransferase, ST1454, ST2180, TA1434, vitamin B12s adenosyltransferase
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2.5.1.17 corrinoid adenosyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.5.1.17 - corrinoid adenosyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 ATP + 2 cob(II)alamin + a reduced flavoprotein
2 triphosphate + 2 adenosylcob(III)alamin + an oxidized flavoprotein
ATP + cob(I)yrinic acid a,c-diamide
triphosphate + adenosylcob(III)yrinic acid a,c-diamide
-
-
-
?
cob(I)alamin + ATP + H2O + H+
adenosylcobalamin + diphosphate + phosphate
-
-
-
-
?
cob(I)alamin + CTP + H2O + H+
cytosylcobalamin + diphosphate + phosphate
-
-
-
-
?
cob(I)alamin + dATP + H2O + H+
deoxyadenosylcobalamin + diphosphate + phosphate
-
-
-
-
?
cob(I)alamin + GTP + H2O + H+
guanosylcobalamin + diphosphate + phosphate
-
low activity
-
-
?
cob(I)alamin + ITP
hypoxanthosylcobalamin + diphosphate + phosphate
-
low activity
-
-
?
cob(I)alamin + UTP
uranylcobalamin + diphosphate + phosphate
-
low activity
-
-
?
2 ATP + 2 cob(II)alamin + a reduced flavoprotein
2 triphosphate + 2 adenosylcob(III)alamin + an oxidized flavoprotein
-
-
-
?
2 ATP + 2 cob(II)alamin + a reduced flavoprotein
2 triphosphate + 2 adenosylcob(III)alamin + an oxidized flavoprotein
Listeria monocytogenes LL195
-
-
-
?
ATP + cob(I)alamin
triphosphate + adenosylcob(I)alamine
-
-
-
-
?
ATP + cob(I)alamin
triphosphate + adenosylcob(III)alamin
-
-
adenosyltransferase enzymes lower the thermodynamic barrier of the Co2+ toCo+ reduction needed for the formation of the unique organometalic Co-C bond of adenosylcobalamin
-
?
ATP + cob(I)alamin
triphosphate + adenosylcob(III)alamin
-
-
adenosyltransferase enzymes lower the thermodynamic barrier of the Co2+ to Co+ reduction needed for the formation of the unique organometalic Co-C bond of adenosylcobalamin
-
?
ATP + cob(I)alamin
triphosphate + adenosylcob(III)alamin
-
final step in the conversion of vitamin B12 to coenzyme B12, the latter being required for degradation of 1,2-propanediol
-
-
?
ATP + cob(I)alamin
triphosphate + adenosylcob(III)alamin
-
last step in the corrinoid adenosylation pathway, EutT and CobA
-
-
ir
ATP + cob(I)alamin
triphosphate + adenosylcob(III)alamin
-
mechanism of adenosylcobalamin biosynthesis
-
-
?
ATP + cob(I)alamin
triphosphate + adenosylcob(III)alamin
last step in the corrinoid adenosylation pathway, EutT and CobA
-
-
ir
ATP + cob(I)alamin
triphosphate + adenosylcobalamin
-
polymorphic variants 239K and 239M, biosynthesis of adenosylcobalamin
-
-
?
ATP + cob(I)alamin
triphosphate + adenosylcobalamin
-
-
?
ATP + cob(I)alamin
triphosphate + coenzyme B12
-
-
-
-
?
ATP + cob(I)alamin
triphosphate + coenzyme B12
-
involved in vitamin B12 metabolism
-
-
?
ATP + cob(I)alamin
triphosphate + coenzyme B12
-
-
-
-
?
ATP + cob(I)alamin
triphosphate + coenzyme B12
-
-
-
?
ATP + cob(I)alamin
triphosphate + coenzyme B12
the main role of this enzyme is apparently the conversion of inactive cobalamins to adenosyl cobalamin for 1,2 propanediol degradation
-
-
?
cob(I)alamin + ATP
adenosylcobalamin + triphosphate
-
adenosylcobalamin is a cofactor required by the methylmalonyl-CoA mutase
-
-
?
cob(I)alamin + ATP
adenosylcobalamin + triphosphate
-
cobalamin assimilation and recycling pathway, overview, enzyme deficiency causes methylmalonic aciduria, MMA, is an autosomal recessive disease with symptoms that include ketoacidosis, lethargy, recurrent vomiting, dehydration, respiratory distress, muscular hypotonia and death due to methylmalonic acid levels that are up to 1000fold greater than normal, overview
-
-
?
cob(I)alamin + ATP
adenosylcobalamin + triphosphate
-
adenosylation of the corrinoid ring of cob(I)alamin generates coenzyme B12, i.e. adenosylcobalamin or AdoCbl, an essential cofactor used by enzymes that catalyze intramolecular rearrangements, deaminations, dehydrations, reductions, and reductive dehalogenations
-
-
?
cob(I)alamin + ATP
adenosylcobalamin + triphosphate
Limosilactobacillus reuteri CRL1098
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adenosylation of the corrinoid ring of cob(I)alamin generates coenzyme B12, i.e. adenosylcobalamin or AdoCbl, an essential cofactor used by enzymes that catalyze intramolecular rearrangements, deaminations, dehydrations, reductions, and reductive dehalogenations
-
-
?
cob(I)alamin + ATP
adenosylcobalamin + triphosphate
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the enzyme is required to adenosylate de novo biosynthetic intermediates of adenosylcobalamin and to salvage incomplete and complete corrinoids from the environment of this bacterium
-
-
?
additional information
?
-
-
ATP:Cobalamin adenosyltransferases catalyze the transfer a 5'-deoxyadenosyl moiety from ATP to cob(I)alamin in the synthesis of the Co-C bond of coenzyme B12
-
-
?
additional information
?
-
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the enzyme interacts with the methionine synthase reductase MSR, which catalyzes the reduction of cob(II)almin to cob(I)alamin, both enzymes activate each other, stoichiometry of the MSR-ATR system, overview
-
-
?
additional information
?
-
-
enzyme defects cause methylmalonic aciduria type B, regulation, overview
-
-
?
additional information
?
-
the enzyme catalyzes the final step in the conversion of cyanocobalamin, i.e. vitamin B12, to the essential human cofactor adenosylcobalamin, defects in the enzyme through mutations in the gene encoding the enzyme can result in the metabolic disorder known as methylmalonic aciduria, MMA
-
-
?
additional information
?
-
-
the enzyme catalyzes the final step in the conversion of cyanocobalamin, i.e. vitamin B12, to the essential human cofactor adenosylcobalamin, defects in the enzyme through mutations in the gene encoding the enzyme can result in the metabolic disorder known as methylmalonic aciduria, MMA
-
-
?
additional information
?
-
-
The PduO-type ATP:corrinoid adenosyltransferase catalyzes the transfer of the adenosyl-group of ATP to Co1+-cobalamin and Co1+-cobinamide substrates to synthesize adenosylcobalamin and adenosylcobinamide, respectively
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-
?
additional information
?
-
-
EutT is necessary and sufficient for growth of a cobA eutT strain on ethanolamine as a carbon and energy or nitrogen source
-
-
?
additional information
?
-
-
the flavodoxin in vivo reducing agent that serves as the electron donor to the enzyme possesses a reduction potential that is considerably more positive than that of the Co2+/1+ couple of the corrinoid substrate, the enzyme overcomes this challenge by formation of an ATP-activated unique paramagnetic Co2+ corrinoid species by partial conversion, overview
-
-
?
additional information
?
-
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EuT substrate specificity, overview, reaction cycle involving EutT and CobA, overview
-
-
?
additional information
?
-
EutT is necessary and sufficient for growth of a cobA eutT strain on ethanolamine as a carbon and energy or nitrogen source
-
-
?
