2.5.1.15: dihydropteroate synthase

This is an abbreviated version!
For detailed information about dihydropteroate synthase, go to the full flat file.

Word Map on EC 2.5.1.15

2.5.1.15

plasmodium

falciparum

malaria

dihydrofolate

pfdhfr

sulfadoxine-pyrimethamine

chloroquine

antimalarial

pneumocystis

pfcrt

antifolate

sulfonamide

pyrimethamine

pfmdr1

uncomplicated

sulfadoxine

quintuple

vivax

artemisinin

jirovecii

sulfa

pcp

dapsone

artemisinin-based

carinii

trimethoprim

p-aminobenzoic

leprae

artesunate

sulfamethoxazole

gyras

paba

amodiaquine

trimethoprim-sulfamethoxazole

artemether-lumefantrine

chloroquine-resistant

mefloquine

sextuple

resistance-mediating

biotechnology

multibacillary

malaria-endemic

cycloguanil

piperaquine

molecular biology

para-aminobenzoic

medicine

atovaquone

drug development

antifolate-resistant

tmp-smx

sulfathiazole

lumefantrine

sulfanilamide

Reaction

(7,8-dihydropterin-6-yl)methyl diphosphate

Synonyms

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropterin-pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropteroate synthase, 7,8-dihydropteroate synthase, 7,8-dihydropteroate synthetase, 7,8-dihydropteroic acid synthetase, BCG3672c, DHP synthase, DHPS, DHPS-HPPK, DHPS/DHPR, dihydroneopterin aldolase-dihydropterin pyrophosphokinase-dihydropteroate synthase, dihydropteroate diphosphorylase, dihydropteroate synthase, dihydropteroate synthase/hydroxymethyldihydropterin pyrophosphokinase, dihydropteroate synthetase, dihydropteroic synthetase, FolP, folP1, folP2, HPPK-DHPS, hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, MbDHPS, MtDHPS, Mycobacterium tuberculosis dihydropteroate synthase, PfDHPS, pfPPK-DHPS, PPPK-DHPS, putative dihydropteroate synthase ortholog, pvdhps, PvHPPK-DHPS, PVX_123230, Rv1207, synthase, dihydropteroate

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.15 dihydropteroate synthase

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Results	in table
4	Activating Compound
36488	AA Sequence
12	Application
1	CAS Registry Number
32	Cloned(Commentary)
2	Cofactor
18	Crystallization (Commentary)
25	General Information
18	IC50 Value
282	Inhibitors
16	kcat/KM [mM/s]
138	Ki Value [mM]
65	KM Value [mM]
5	Localization
11	Metals/Ions
24	Molecular Weight [Da]
61	Natural Substrates/ Products (Substrates)
114	Organism
6	Pathway
162	PDB ID
14	pH Optimum
3	pH Range
1	pH Stability
1	pI Value
93	Protein Variants
30	Purification (Commentary)
4	Reaction
7	Reaction Type
99	Reference
11	Source Tissue
25	Specific Activity [micromol/min/mg]
8	Storage Stability
109	Substrates and Products (Substrate)
14	Subunits
144	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
35	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.5.1.15 - dihydropteroate synthase

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(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate

diphosphate + 7,8-dihydropteroate

4 entries

(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate

7,8-dihydropteroate + diphosphate

Plasmodium falciparum

Q25704

759184

(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate

diphosphate + 7,8-dihydropteroate

21 entries

2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate

diphosphate + 7,8-dihydropteroate

21 entries

2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoylglutamate

diphosphate + dihydrofolate

Lactiplantibacillus plantarum

1022

2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + sulfamethoxazole

diphosphate + dihydropterin-sulfamethoxazole

2 entries

4-aminobenzoate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate

diphosphate + 7,8-dihydropteroate

2 entries

6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate

diphosphate + 7,8-dihydropteroate

2 entries

additional information

Plasmodium vivax

amino acid V585 may be responsible for resistance of Plasmodium vivax to sulfadoxine

660718