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0.043
2-amino-4-hydroxy-6-hydroxymethyl-dihydropteridine
-
-
0.0036
6-hydroxymethylpterin monophosphate
100 microM 4-aminobenzoate
0.005 - 0.011
7,8-dihydropteroate
1
p-aminobenzoylglutamate
-
-
0.0082 - 0.023
p-Aminosalicylic acid
0.0015 - 0.94
sulfachloropyridazine
0.0008 - 0.116
sulfadimethoxine
0.0015 - 0.227
sulfadoxine
0.0008 - 0.058
sulfamethazine
0.000028 - 1.17
sulfamethoxazole
0.000025 - 0.0033
sulfamethoxypyridazine
0.0006 - 0.035
sulfamonomethoxine
0.00085 - 0.13
sulfanilamide
0.0016
sulfaquinoxaline
-
-
0.025
sulfaquinoxazoline
-
-
0.00015 - 0.5
sulfathiazole
additional information
additional information
-
0.005 - 0.008
7,8-dihydropteroate
-
inhibitor of p-aminobenzoic acid
0.007 - 0.011
7,8-dihydropteroate
-
inhibitor of 6-hydroxymethyl-7,8-dihydropteridine diphosphate
0.000011
dapsone
-
0.00011
dapsone
-
wild-type enzyme, pH 9.0, 37°C
0.00053
dapsone
-
mutant enzyme V585A, pH 9.0, 37°C
0.00068
dapsone
wild tpye
0.0008
dapsone
wild type enzyme, at pH 9.0 and 37°C
0.0011
dapsone
mutant enzyme K540E, at pH 9.0 and 37°C
0.0014
dapsone
mutant enzyme A613S, at pH 9.0 and 37°C
0.0019
dapsone
mutant enzyme A437G, at pH 9.0 and 37°C
0.00205
dapsone
mutant T557A
0.00367
dapsone
-
mutant enzyme A383G, pH 9.0, 37°C
0.0039
dapsone
mutant enzyme A437G/K540E, at pH 9.0 and 37°C
0.00454
dapsone
-
mutant enzyme A383G/A553G, pH 9.0, 37°C
0.007
dapsone
mutant enzyme A613T, at pH 9.0 and 37°C
0.0148
dapsone
mutant P559S
0.01773
dapsone
-
mutant enzyme S382A/A383G/A553G, pH 9.0, 37°C
0.04
dapsone
mutant enzyme A581G, at pH 9.0 and 37°C
0.058
dapsone
mutant enzyme S436F/A437G/A613S, at pH 9.0 and 37°C
0.156
dapsone
mutant enzyme S436F/A437G/A613T, at pH 9.0 and 37°C
0.177
dapsone
mutant enzyme S436F/A613S, at pH 9.0 and 37°C
0.192
dapsone
mutant enzyme S436F/A613T, at pH 9.0 and 37°C
1.16
dapsone
mutant T557A/P559S
1.29
dapsone
mutant T557V/P559S
0.0082
p-Aminosalicylic acid
-
-
0.023
p-Aminosalicylic acid
-
-
0.0006
Pteroate
mutant enzyme S436F/A437G/A613T, at pH 9.0 and 37°C
0.0009
Pteroate
mutant enzyme S436F/A437G/A613S, at pH 9.0 and 37°C
0.001
Pteroate
mutant enzyme S436A/A437G, at pH 9.0 and 37°C
0.0014
Pteroate
wild type enzyme, at pH 9.0 and 37°C
0.0017
Pteroate
mutant enzyme S436F/A613T, at pH 9.0 and 37°C
0.003
Pteroate
mutant enzyme A613T, at pH 9.0 and 37°C
0.003
Pteroate
mutant enzyme K540E, at pH 9.0 and 37°C
0.0033
Pteroate
mutant enzyme A613S, at pH 9.0 and 37°C
0.0037
Pteroate
mutant enzyme S436F/A613S, at pH 9.0 and 37°C
0.0038
Pteroate
mutant enzyme A437G, at pH 9.0 and 37°C
0.0069
Pteroate
mutant enzyme A437G/K540E, at pH 9.0 and 37°C
0.039
Pteroate
mutant enzyme A581G, at pH 9.0 and 37°C
0.0015
sulfachloropyridazine
-
-
0.00295
sulfachloropyridazine
wild tpye
0.0063
sulfachloropyridazine
mutant T557A
0.0513
sulfachloropyridazine
mutant P559S
0.096
sulfachloropyridazine
mutant T557A/P559S
0.94
sulfachloropyridazine
mutant T557V/P559S
0.0008
sulfadimethoxine
wild type enzyme, at pH 9.0 and 37°C
0.0018
sulfadimethoxine
-
-
0.0024
sulfadimethoxine
mutant enzyme A437G, at pH 9.0 and 37°C
0.014
sulfadimethoxine
mutant enzyme S436A/A437G, at pH 9.0 and 37°C
0.016
sulfadimethoxine
mutant enzyme A437G/K540E, at pH 9.0 and 37°C
0.04
sulfadimethoxine
mutant enzyme S436F/A437G/A613S, at pH 9.0 and 37°C
0.116
sulfadimethoxine
mutant enzyme S436F/A437G/A613T, at pH 9.0 and 37°C
0.0015
sulfadoxine
-
wild-type enzyme, pH 9.0, 37°C
0.003
sulfadoxine
-
mutant enzyme V585A, pH 9.0, 37°C
0.0052
sulfadoxine
mutant enzyme A613T, at pH 9.0 and 37°C
0.007
sulfadoxine
mutant enzyme A437G, at pH 9.0 and 37°C
0.0071
sulfadoxine
wild type enzyme, at pH 9.0 and 37°C
0.0092
sulfadoxine
mutant enzyme A613S, at pH 9.0 and 37°C
0.02
sulfadoxine
mutant enzyme S436A/A437G, at pH 9.0 and 37°C
0.023
sulfadoxine
mutant enzyme K540E, at pH 9.0 and 37°C
0.0481
sulfadoxine
-
mutant enzyme A383G, pH 9.0, 37°C
0.07
sulfadoxine
mutant enzyme A437G/K540E, at pH 9.0 and 37°C
0.084
sulfadoxine
mutant enzyme S436F/A437G/A613S, at pH 9.0 and 37°C
0.086
sulfadoxine
mutant enzyme S436F/A613S, at pH 9.0 and 37°C
0.124
sulfadoxine
mutant enzyme S436F/A613T, at pH 9.0 and 37°C
0.176
sulfadoxine
-
mutant enzyme A383G/A553G, pH 9.0, 37°C
0.196
sulfadoxine
mutant enzyme S436F/A437G/A613T, at pH 9.0 and 37°C
0.198
sulfadoxine
mutant enzyme A581G, at pH 9.0 and 37°C
0.227
sulfadoxine
-
mutant enzyme S382A/A383G/A553G, pH 9.0, 37°C
0.0008
sulfamethazine
wild type enzyme, at pH 9.0 and 37°C
0.0016
sulfamethazine
mutant enzyme A437G, at pH 9.0 and 37°C
0.0071
sulfamethazine
mutant enzyme A437G/K540E, at pH 9.0 and 37°C
0.021
sulfamethazine
mutant enzyme S436F/A437G/A613S, at pH 9.0 and 37°C
0.058
sulfamethazine
mutant enzyme S436F/A437G/A613T, at pH 9.0 and 37°C
0.000028
sulfamethoxazole
-
0.00003
sulfamethoxazole
-
0.00013
sulfamethoxazole
-
-
0.00059
sulfamethoxazole
-
-
0.00371
sulfamethoxazole
mutant T557A
0.0044
sulfamethoxazole
-
-
0.0085
sulfamethoxazole
wild tpye
0.034
sulfamethoxazole
wild type enzyme, at pH 9.0 and 37°C
0.0543
sulfamethoxazole
mutant P559S
0.153
sulfamethoxazole
mutant enzyme A437G, at pH 9.0 and 37°C
0.462
sulfamethoxazole
mutant enzyme S436F/A437G/A613S, at pH 9.0 and 37°C
0.48
sulfamethoxazole
mutant enzyme A437G/K540E, at pH 9.0 and 37°C
0.731
sulfamethoxazole
mutant enzyme S436F/A437G/A613T, at pH 9.0 and 37°C
0.76
sulfamethoxazole
mutant T557V/P559S
1.17
sulfamethoxazole
mutant T557A/P559S
0.000025
sulfamethoxypyridazine
-
0.000031
sulfamethoxypyridazine
-
0.0033
sulfamethoxypyridazine
-
-
0.0006
sulfamonomethoxine
wild type enzyme, at pH 9.0 and 37°C
0.0018
sulfamonomethoxine
mutant enzyme A437G, at pH 9.0 and 37°C
0.0091
sulfamonomethoxine
mutant enzyme A437G/K540E, at pH 9.0 and 37°C
0.014
sulfamonomethoxine
mutant enzyme S436F/A437G/A613S, at pH 9.0 and 37°C
0.035
sulfamonomethoxine
mutant enzyme S436F/A437G/A613T, at pH 9.0 and 37°C
0.00085
sulfanilamide
-
-
0.00015
sulfathiazole
-
wild-type enzyme, pH 9.0, 37°C
0.00019
sulfathiazole
-
mutant enzyme V585A, pH 9.0, 37°C
0.0005
sulfathiazole
wild type enzyme, at pH 9.0 and 37°C
0.0016
sulfathiazole
mutant enzyme A437G, at pH 9.0 and 37°C
0.00295
sulfathiazole
-
mutant enzyme A383G, pH 9.0, 37°C
0.0072
sulfathiazole
mutant enzyme S436A/A437G, at pH 9.0 and 37°C
0.01553
sulfathiazole
-
mutant enzyme A383G/A553G, pH 9.0, 37°C
0.018
sulfathiazole
mutant enzyme A437G/K540E, at pH 9.0 and 37°C
0.019
sulfathiazole
-
mutant enzyme S382A/A383G/A553G, pH 9.0, 37°C
0.025
sulfathiazole
mutant enzyme S436F/A437G/A613T, at pH 9.0 and 37°C
0.027
sulfathiazole
mutant enzyme S436F/A437G/A613S, at pH 9.0 and 37°C
0.5
sulfathiazole
-
resistant enzyme
additional information
additional information
-
KI values of sulfathiazole inhibition on Streptococcus pneumoniae strains with different repeats of amino acids
-
additional information
additional information
-
KI values of sulfathiazole for wild-type and mutant enzyme
-
additional information
additional information
-
KI values of folate derivatives
-
additional information
additional information
-
KI values of sulfadoxine for recombinant enzymes
-