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2.5.1.15: dihydropteroate synthase

This is an abbreviated version!
For detailed information about dihydropteroate synthase, go to the full flat file.

Word Map on EC 2.5.1.15

Reaction

(7,8-dihydropterin-6-yl)methyl diphosphate
+
4-Aminobenzoate
=
diphosphate
+
7,8-dihydropteroate

Synonyms

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropterin-pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropteroate synthase, 7,8-dihydropteroate synthase, 7,8-dihydropteroate synthetase, 7,8-dihydropteroic acid synthetase, BCG3672c, DHP synthase, DHPS, DHPS-HPPK, DHPS/DHPR, dihydroneopterin aldolase-dihydropterin pyrophosphokinase-dihydropteroate synthase, dihydropteroate diphosphorylase, dihydropteroate synthase, dihydropteroate synthase/hydroxymethyldihydropterin pyrophosphokinase, dihydropteroate synthetase, dihydropteroic synthetase, FolP, folP1, folP2, HPPK-DHPS, hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, MbDHPS, MtDHPS, Mycobacterium tuberculosis dihydropteroate synthase, PfDHPS, pfPPK-DHPS, PPPK-DHPS, putative dihydropteroate synthase ortholog, pvdhps, PvHPPK-DHPS, PVX_123230, Rv1207, synthase, dihydropteroate

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.15 dihydropteroate synthase

KI Value

KI Value on EC 2.5.1.15 - dihydropteroate synthase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.043
2-amino-4-hydroxy-6-hydroxymethyl-dihydropteridine
-
-
0.0036
6-hydroxymethylpterin monophosphate
100 microM 4-aminobenzoate
0.005 - 0.011
7,8-dihydropteroate
0.000011 - 1.29
dapsone
0.015
folate
-
-
1
p-aminobenzoylglutamate
-
-
0.0082 - 0.023
p-Aminosalicylic acid
0.0006 - 0.039
Pteroate
0.0941
sulfacetamide
-
-
0.0015 - 0.94
sulfachloropyridazine
0.0068
Sulfadiazine
-
-
0.0008 - 0.116
sulfadimethoxine
0.0015 - 0.227
sulfadoxine
0.069
Sulfaguanidine
-
-
0.0048
sulfamerazine
-
-
0.0008 - 0.058
sulfamethazine
0.000028 - 1.17
sulfamethoxazole
0.000025 - 0.0033
sulfamethoxypyridazine
0.0006 - 0.035
sulfamonomethoxine
0.0027
sulfamoxole
-
-
0.00085 - 0.13
sulfanilamide
0.14
Sulfanilic acid
-
-
0.0019
sulfapyridine
-
-
0.0016
sulfaquinoxaline
-
-
0.025
sulfaquinoxazoline
-
-
0.00015 - 0.5
sulfathiazole
0.0076
sulfisoxazole
-
-
0.00053
sulfonamide
-
-
additional information
additional information
-