2.5.1.15: dihydropteroate synthase

This is an abbreviated version!
For detailed information about dihydropteroate synthase, go to the full flat file.

Reaction

Synonyms

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropterin-pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropteroate synthase, 7,8-dihydropteroate synthase, 7,8-dihydropteroate synthetase, 7,8-dihydropteroic acid synthetase, BCG3672c, DHP synthase, DHPS, DHPS-HPPK, DHPS/DHPR, dihydroneopterin aldolase-dihydropterin pyrophosphokinase-dihydropteroate synthase, dihydropteroate diphosphorylase, dihydropteroate synthase, dihydropteroate synthase/hydroxymethyldihydropterin pyrophosphokinase, dihydropteroate synthetase, dihydropteroic synthetase, FolP, folP1, folP2, HPPK-DHPS, hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, MbDHPS, MtDHPS, Mycobacterium tuberculosis dihydropteroate synthase, PfDHPS, pfPPK-DHPS, PPPK-DHPS, putative dihydropteroate synthase ortholog, pvdhps, PvHPPK-DHPS, PVX_123230, Rv1207, synthase, dihydropteroate

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.15 dihydropteroate synthase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
4	Activating Compound
36488	AA Sequence
12	Application
1	CAS Registry Number
32	Cloned(Commentary)
2	Cofactor
18	Crystallization (Commentary)
25	General Information
18	IC50 Value
282	Inhibitors
16	kcat/KM [mM/s]
138	Ki Value [mM]
65	KM Value [mM]
5	Localization
11	Metals/Ions
24	Molecular Weight [Da]
61	Natural Substrates/ Products (Substrates)
114	Organism
6	Pathway
162	PDB ID
14	pH Optimum
3	pH Range
1	pH Stability
1	pI Value
93	Protein Variants
30	Purification (Commentary)
4	Reaction
7	Reaction Type
99	Reference
11	Source Tissue
25	Specific Activity [micromol/min/mg]
8	Storage Stability
109	Substrates and Products (Substrate)
14	Subunits
144	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
35	Turnover Number [1/s]

IC50 Value

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

IC50 Value on EC 2.5.1.15 - dihydropteroate synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to IC50 Value Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.017 - 0.05

2-(7-amino-1-methyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)propanoic acid

3 entries

0.0113 - 0.0178

2-amino-6-[[4-(4-aminobenzene-1-sulfonyl)anilino]methyl]pteridin-4(1H)-one

2 entries

0.0019 - 0.0268

4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-N-(2,6-dimethoxypyrimidin-4-yl)benzene-1-sulfonamide

2 entries

0.0081 - 0.0225

4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide

2 entries

0.0115 - 0.0152

4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-N-(5,6-dimethoxypyrimidin-4-yl)benzene-1-sulfonamide

2 entries

0.0034 - 0.0206

4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-N-(5-methyl-1,2-oxazol-3-yl)benzene-1-sulfonamide

2 entries

0.0025

4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-N-(pyridin-2-yl)benzene-1-sulfonamide

Bacillus anthracis

Q81VW8

pH and temperature not specified in the publication, fluorescence polarization based competition binding assay, in presence of 2 mM sodium diphosphate

758913

0.0094 - 0.0193

4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-N-(pyrimidin-2-yl)benzene-1-sulfonamide

2 entries

0.0171 - 0.0186

N-(4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]benzene-1-sulfonyl)acetamide

2 entries

0.017

2-(7-amino-1-methyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)propanoic acid

Staphylococcus aureus

-

at pH 7.6 and 37°C

737323

0.031

2-(7-amino-1-methyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)propanoic acid

Yersinia pestis

-

at pH 7.6 and 37°C

737323

0.05

2-(7-amino-1-methyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)propanoic acid

Bacillus anthracis

Q81VW8

at pH 7.6 and 37°C

737323

0.0113

2-amino-6-[[4-(4-aminobenzene-1-sulfonyl)anilino]methyl]pteridin-4(1H)-one

Bacillus anthracis

Q81VW8

pH and temperature not specified in the publication, fluorescence polarization based competition binding assay, in presence of 2 mM sodium diphosphate

758913

0.0178

2-amino-6-[[4-(4-aminobenzene-1-sulfonyl)anilino]methyl]pteridin-4(1H)-one

Bacillus anthracis

Q81VW8

pH and temperature not specified in the publication, fluorescence polarization based competition binding assay, without sodium diphosphate

758913

0.0019

4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-N-(2,6-dimethoxypyrimidin-4-yl)benzene-1-sulfonamide

Bacillus anthracis

Q81VW8

pH and temperature not specified in the publication, fluorescence polarization based competition binding assay, in presence of 2 mM sodium diphosphate

758913

0.0268

4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-N-(2,6-dimethoxypyrimidin-4-yl)benzene-1-sulfonamide

Bacillus anthracis

Q81VW8

pH and temperature not specified in the publication, fluorescence polarization based competition binding assay, without sodium diphosphate

758913

0.0081

4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide

Bacillus anthracis

Q81VW8

pH and temperature not specified in the publication, fluorescence polarization based competition binding assay

758913

0.0225

4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide

Bacillus anthracis

Q81VW8

pH and temperature not specified in the publication, fluorescence polarization based competition binding assay

758913

0.0115

4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-N-(5,6-dimethoxypyrimidin-4-yl)benzene-1-sulfonamide

Bacillus anthracis

Q81VW8

pH and temperature not specified in the publication, fluorescence polarization based competition binding assay, in presence of 2 mM sodium diphosphate

758913

0.0152

4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-N-(5,6-dimethoxypyrimidin-4-yl)benzene-1-sulfonamide

Bacillus anthracis

Q81VW8

pH and temperature not specified in the publication, fluorescence polarization based competition binding assay

758913

0.0034

4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-N-(5-methyl-1,2-oxazol-3-yl)benzene-1-sulfonamide

Bacillus anthracis

Q81VW8

pH and temperature not specified in the publication, fluorescence polarization based competition binding assay, in presence of 2 mM sodium diphosphate

758913

0.0206

4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-N-(5-methyl-1,2-oxazol-3-yl)benzene-1-sulfonamide

Bacillus anthracis

Q81VW8

pH and temperature not specified in the publication, fluorescence polarization based competition binding assay, without sodium diphosphate

758913

0.0094

4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-N-(pyrimidin-2-yl)benzene-1-sulfonamide

Bacillus anthracis

Q81VW8

pH and temperature not specified in the publication, fluorescence polarization based competition binding assay, in presence of 2 mM sodium diphosphate

758913

0.0193

4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-N-(pyrimidin-2-yl)benzene-1-sulfonamide

Bacillus anthracis

Q81VW8

pH and temperature not specified in the publication, fluorescence polarization based competition binding assay, without sodium diphosphate

758913

0.0171

N-(4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]benzene-1-sulfonyl)acetamide

Bacillus anthracis

Q81VW8

pH and temperature not specified in the publication, fluorescence polarization based competition binding assay, in presence of 2 mM sodium diphosphate

758913

0.0186

N-(4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]benzene-1-sulfonyl)acetamide

Bacillus anthracis

Q81VW8

pH and temperature not specified in the publication, fluorescence polarization based competition binding assay

758913