2.5.1.132: 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase

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For detailed information about 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase, go to the full flat file.

Reaction

Synonyms

2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid synthase, 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase, 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase, BT1714, KDN 9-phosphate synthase, KDN-9-P synthase, KDN-9-phosphate synthetase, KDN-9P synthase, N-acetylneuraminic acid phosphate synthase, Neu5Ac 9-phosphate synthase, neu5ac-9-P synthase, NeuNAc-9-P synthase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.132 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase

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Results	in table
2	AA Sequence
3	Cloned(Commentary)
2	Disease/ Diagnostics
2	Inhibitors
4	kcat/KM [mM/s]
5	KM Value [mM]
1	Metals/Ions
2	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
7	Organism
3	Pathway
3	pH Optimum
4	Protein Variants
4	Purification (Commentary)
1	Reaction
7	Reference
4	Source Tissue
1	Specific Activity [micromol/min/mg]
10	Substrates and Products (Substrate)
1	Subunits
15	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
4	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.5.1.132 - 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase

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SYSTEMATIC NAME

IUBMB Comments

phosphoenolpyruvate:D-mannose-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase

The enzyme participates in the biosynthesis of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). The human sialic acid synthase (EC 2.5.1.57) is also able to catalyse the reaction. Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.