2.5.1.132: 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase
This is an abbreviated version!
For detailed information about 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase, go to the full flat file.
Reaction
Synonyms
2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid synthase, 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase, 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase, BT1714, KDN 9-phosphate synthase, KDN-9-P synthase, KDN-9-phosphate synthetase, KDN-9P synthase, N-acetylneuraminic acid phosphate synthase, Neu5Ac 9-phosphate synthase, neu5ac-9-P synthase, NeuNAc-9-P synthase
ECTree
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Inhibitors
Inhibitors on EC 2.5.1.132 - 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase
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EDTA
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the enzyme is active in the absence of exogenously added divalent cations but lost all activity when incubated before assay with 5 mM EDTA. The lost enzyme activity is restored to 2.43 times higher levels of the original one by the addition of 1 mM MnCl2, CoCl2, or NiCl2 and to one-third the original activity by 1 mM MgCl2. The other cations (Ca2+, Fe2+, Cu2+, and Zn2+) do not restore enzyme activity
NaCl
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activity is reduced by about 50% in the presence of 150 mM NaCl compared with the activity without added NaCl