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2.5.1.115: homogentisate phytyltransferase

This is an abbreviated version!
For detailed information about homogentisate phytyltransferase, go to the full flat file.

Word Map on EC 2.5.1.115

Reaction

phytyl diphosphate
+
homogentisate
=
diphosphate
 +
2-methyl-6-phytylbenzene-1,4-diol
 +
CO2

Synonyms

At2g18950, HPT, HPT1, RTD1, slr1736, SynHPT, VTE2, VTE2-1, VTE2-2, VTE2.1

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.115 homogentisate phytyltransferase

Application

Application on EC 2.5.1.115 - homogentisate phytyltransferase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
agriculture
nutrition
in leaves, isoform HPT1 constitutive overexpression results in a 10fold increase in HPT specific activity and a 4.4fold increase in total tocopherol content relative to wild type. In seeds, HPT1 overexpression results in a 4fold increase in HPT specific activity and a total seed tocopherol content that is 40% higher than wild type, primarily because of an increase in gamma-tocopherol content. This enlarged pool of gamma-tocopherol is almost entirely converted to alpha-tocopherol by crossing HPT1 overexpressing plants with lines constitutively overexpressing gamma-tocopherol methyltransferase. Seed of the resulting double-overexpressing lines displays a 12fold increase in vitamin E activity relative to wild type
synthesis
constitutive expression of genes encoding homogentisate phytyltransferase HPT and tocopherol cyclase TC individually and in combination in tobacco. The alpha-tocopherol content in transgenic tobacco plants expressing HPT, TC, and both HPT and TC is increased by 5.4-, 4.0-, and 7.1fold, respectively, when compared to the wild type