2.5.1.113: [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase

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For detailed information about [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase, go to the full flat file.

Word Map on EC 2.5.1.113

2.5.1.113

tubulin

microtubule

polyglutamylation

glutamylation

ligase-like

deglutamylated

cilia

purkinje

carboxypeptidase

Reaction

[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH

[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine

Synonyms

CysM, Cysteine synthase, O-phosphoserine sulfhydrylase, O-phosphoserine-specific cysteine synthase, Rv1336

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.113 [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase

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Results	in table
86	AA Sequence
4	Cloned(Commentary)
3	Cofactor
3	Crystallization (Commentary)
4	kcat/KM [mM/s]
9	Natural Substrates/ Products (Substrates)
391	Organism
1	Pathway
22	PDB ID
4	Protein Variants
4	Purification (Commentary)
1	Reaction
9	Reference
12	Substrates and Products (Substrate)
3	Subunits
16	Synonyms
1	Systematic Name
1	Turnover Number [1/s]

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Reference on EC 2.5.1.113 - [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase

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685195

OLeary, S.E.; Jurgenson, C.T.; Ealick, S.E.; Begley, T.P.

O-Phospho-l-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis

Biochemistry

11606-11615

2008

Mycobacterium tuberculosis

18842002

687773

Agren, D.; Schnell, R.; Oehlmann, W.; Singh, M.; Schneider, G.

Cysteine synthase (CYSM) of Mycobacterium tuberculosis is an O-phosphoserine sulfhydrylase: Evidence for an alternative cysteine biosynthesis pathway in mycobacteria

J. Biol. Chem.

283

31567-31574

2008

Mycobacterium tuberculosis (P9WP53), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WP53)

18799456

702213

Jurgenson, C.T.; Burns, K.E.; Begley, T.P.; Ealick, S.E.

Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis

Biochemistry

10354-10364

2008

Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv

18771296

724996

Agren, D.; Schnell, R.; Schneider, G.

The C-terminal of CysM from Mycobacterium tuberculosis protects the aminoacrylate intermediate and is involved in sulfur donor selectivity

FEBS Lett.

583

330-336

2009

Mycobacterium tuberculosis (P9WP53), Mycobacterium tuberculosis H37Rv (P9WP53)

19101553

760223

Burns-Huang, K.; Mundhra, S.

Mycobacterium tuberculosis cysteine biosynthesis genes mec+-cysO-cysM confer resistance to clofazimine

Tuberculosis

115

63-66

2019

Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv

30948178