2.5.1.113: [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase

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For detailed information about [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase, go to the full flat file.

Reaction

Synonyms

CysM, Cysteine synthase, O-phosphoserine sulfhydrylase, O-phosphoserine-specific cysteine synthase, Rv1336

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.113 [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase

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Results	in table
86	AA Sequence
4	Cloned(Commentary)
3	Cofactor
3	Crystallization (Commentary)
4	kcat/KM [mM/s]
9	Natural Substrates/ Products (Substrates)
391	Organism
1	Pathway
22	PDB ID
4	Protein Variants
4	Purification (Commentary)
1	Reaction
9	Reference
12	Substrates and Products (Substrate)
3	Subunits
16	Synonyms
1	Systematic Name
1	Turnover Number [1/s]

Engineering

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Engineering on EC 2.5.1.113 - [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

DELTA319-323

Mycobacterium tuberculosis

P9WP53

the deletion mutant shows increased catalytic efficiency for O-phospho-L-serine and reduced catalytic efficiency for [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH

724996

R220A

Mycobacterium tuberculosis

P9WP53

the mutant shows reduced activity with O-phospho-L-serine and increased activity with O-acetyl-L-serine compared to the wild type enzyme

687773

DELTA319-323

Mycobacterium tuberculosis H37Rv

-

the deletion mutant shows increased catalytic efficiency for O-phospho-L-serine and reduced catalytic efficiency for [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH

-

R220A

Mycobacterium tuberculosis H37Rv

-

the mutant shows reduced activity with O-phospho-L-serine and increased activity with O-acetyl-L-serine compared to the wild type enzyme

-