2.5.1.111: 4-hydroxyphenylpyruvate 3-dimethylallyltransferase

This is an abbreviated version!
For detailed information about 4-hydroxyphenylpyruvate 3-dimethylallyltransferase, go to the full flat file.

Word Map on EC 2.5.1.111

2.5.1.111

geranylation

isoprenylation

dmapp

dimethylallyltryptophan

clorobiocin

isonitrile

hapalindole-type

aptase

synthesis

Reaction

Synonyms

4HPP dimethylallyltransferase, apT, aromatic prenyltransferase, CloQ, FamD1, isoprenyl transferase, NovQ

ECTree

2 Transferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

2.5.1.111 4-hydroxyphenylpyruvate 3-dimethylallyltransferase

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Results	in table
5	AA Sequence
2	Application
8	Cloned(Commentary)
4	Crystallization (Commentary)
1	Expression
4	General Information
3	Inhibitors
13	kcat/KM [mM/s]
17	KM Value [mM]
8	Metals/Ions
3	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
18	Organism
3	Pathway
4	pH Optimum
23	Protein Variants
7	Purification (Commentary)
1	Reaction
16	Reference
51	Substrates and Products (Substrate)
8	Subunits
22	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
15	Turnover Number [1/s]

General Information

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General Information on EC 2.5.1.111 - 4-hydroxyphenylpyruvate 3-dimethylallyltransferase

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malfunction

Streptomyces roseochromogenus subsp. oscitans

Q8GHB2

cloQ-defective mutant of the clorobiocin producer Streptomyces roseochromogenes, which is blocked in the biosynthesis of the prenylated 4-hydroxybenzoic acid moiety of clorobiocin produces three new antibiotics, vanillobiocin, isovanillobiocin and declovanillobiocin. The isolated compounds are similar to clorobiocin, but contain vanillic acid as the acyl component instead of the prenylated 4-hydroxybenzoic acid present in clorobiocin. Isovanillobiocin differs from vanillobiocin by the position of the pyrrole unit attached to the sugar moiety of the antibiotic. Declovanillobiocin lacks the chlorine atom at the aminocoumarin ring. All three compounds have lower antibiotic activity against Bacillus subtilis than clorobiocin

722464

physiological function

3 entries