2.5.1.108: 2-(3-amino-3-carboxypropyl)histidine synthase
This is an abbreviated version!
For detailed information about 2-(3-amino-3-carboxypropyl)histidine synthase, go to the full flat file.
Word Map on EC 2.5.1.108
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2.5.1.108
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diphtheria
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toxin
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horikoshii
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pyrococcus
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s-adenosylmethionine
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cluster-containing
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fe-s
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heterodimer
- 2.5.1.108
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diphtheria
- toxin
- horikoshii
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pyrococcus
- s-adenosylmethionine
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cluster-containing
- fe-s
- heterodimer
Reaction
Synonyms
diphthamide biosynthesis protein 2, diphthine synthase, Dph1-Dph2, Dph2, DPH4, PhDph2, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase
ECTree
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Substrates Products
Substrates Products on EC 2.5.1.108 - 2-(3-amino-3-carboxypropyl)histidine synthase
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REACTION DIAGRAM
5'-deoxy-5'-(3-(3-N,N-dimethylamino)phenoxy)propyl-5'-methyl-5'-thioadenosine + a protein
5'-deoxy-5'-(3-(3-N,N-dimethylamino)phenoxy)propyl-5'-thioadenosine + a methylated protein
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5'-deoxy-5'-(3-phenoxy)propyl-5'-methyl-5'-thioadenosine + a protein
5'-deoxy-5'-(3-phenoxy)propyl-5'-thioadenosine + a methylated protein
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?
L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine
2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine
L-histidine-[translation elongation factor 2] + [[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl][(2E)-3-carboxyprop-2-en-1-yl]methylsulfonium
2-(3-carboxyprop-2-en-1-yl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine
S-adenosyl-L-methionine analogue, in which the 3-amino-3-carboxypropyl group is replaced with a 3-carboxyallyl group. The analogue is cleaved by Dph2, yielding a paramagnetic (S = 1/2) species, which is assigned to a complex formed between the reaction product, alpha-sulfinyl-3-butenoic acid, and the [4Fe-4S] cluster. Data support a pi-complex between the C=C double bond of alpha-sulfinyl-3-butenoic acid and the unique iron of the [4Fe-4S] cluster, i.e. a radical S-adenosyl-L-methionine-related [4Fe-4S]+ cluster forming an organometallic complex with an alkene
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S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]
S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-carboxypropyl]-L-histidine-[translation elongation factor 2]
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S-adenosyl-L-methionine + L-histidine600-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine500-[translation elongation factor 2]
the enzyme is involved in diphthamide biosynthesis
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S-adenosyl-L-methionine + L-histidine600-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine600-[translation elongation factor 2]
S-adenosyl-L-methionine + L-histidine699-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine699-[translation elongation factor 2]
the enzyme is involved in diphthamide biosynthesis
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S-adenosyl-L-methionine + L-histidine715-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine715-[translation elongation factor 2]
the enzyme is involved in diphthamide biosynthesis
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additional information
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no activity is detected using dithionite or the Dph3/Cbr1/NADH system as the reductant
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2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine
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L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine
2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine
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?
L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine
2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine
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?
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]
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?
S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]
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?
S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]
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?
S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]
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?
S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]
first step of diphthamide biosynthesis, a unique posttranslational modification on a histidine residue of translational elongation factor 2
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S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]
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S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]
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S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine600-[translation elongation factor 2]
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S-adenosyl-L-methionine + L-histidine600-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine600-[translation elongation factor 2]
the enzyme is involved in diphthamide biosynthesis
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?
S-adenosyl-L-methionine + L-histidine600-[translation elongation factor 2]
S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine600-[translation elongation factor 2]
the 3-amino-3-carboxypropyl radical is added to the imidazole ring in the pathway towards the formation of the product
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