2.5.1.108: 2-(3-amino-3-carboxypropyl)histidine synthase
This is an abbreviated version!
For detailed information about 2-(3-amino-3-carboxypropyl)histidine synthase, go to the full flat file.
Word Map on EC 2.5.1.108
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2.5.1.108
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diphtheria
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toxin
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horikoshii
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pyrococcus
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s-adenosylmethionine
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cluster-containing
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fe-s
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heterodimer
- 2.5.1.108
-
diphtheria
- toxin
- horikoshii
-
pyrococcus
- s-adenosylmethionine
-
cluster-containing
- fe-s
- heterodimer
Reaction
Synonyms
diphthamide biosynthesis protein 2, diphthine synthase, Dph1-Dph2, Dph2, DPH4, PhDph2, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase
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General Information
General Information on EC 2.5.1.108 - 2-(3-amino-3-carboxypropyl)histidine synthase
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malfunction
physiological function
malfunction
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loss of Dph4 results in lack of diphthamide modification of eEF2 and resistance to diphtheria toxin. Dph4 mutant mice are growth retarded and have a specific digit defect with one or more additional preaxial digits
first step of diphthamide biosynthesis, a unique posttranslational modification on a histidine residue of translational elongation factor 2
physiological function
the enzyme is involved in diphthamide biosynthesis
physiological function
the enzyme is involved in diphthamide biosynthesis
physiological function
the enzyme is involved in diphthamide biosynthesis
physiological function
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diphthamide biosynthesis proteins Dph1 and Dph2 interact and the first step of diphthamide formation on eukaryotic translation elongation factor eEF2 requires a complex formed in vivo between Dph1, Dph2 and Dph3