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2.5.1.106: tryprostatin B synthase

This is an abbreviated version!
For detailed information about tryprostatin B synthase, go to the full flat file.

Word Map on EC 2.5.1.106

Reaction

dimethylallyl diphosphate
+
brevianamide F
=
diphosphate
+
tryprostatin B

Synonyms

brevianamide F prenyltransferase, cyclic dipeptide C2-prenyltransferase FtmPT1, FtmPT1, indole prenyltransferase, tryprostatin B synthase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.106 tryprostatin B synthase

Reference

Reference on EC 2.5.1.106 - tryprostatin B synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wollinsky, B.; Ludwig, L.; Hamacher, A.; Yu, X.; Kassack, M.U.; Li, S.M.
Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides
Bioorg. Med. Chem. Lett.
22
3866-3869
2012
Aspergillus fumigatus (Q4WAW7), Aspergillus fumigatus Af293 (Q4WAW7)
Manually annotated by BRENDA team
Jost, M.; Zocher, G.; Tarcz, S.; Matuschek, M.; Xie, X.; Li, S.M.; Stehle, T.
Structure-function analysis of an enzymatic prenyl transfer reaction identifies a reaction chamber with modifiable specificity
J. Am. Chem. Soc.
132
17849-17858
2010
Aspergillus fumigatus (Q4WAW7), Aspergillus fumigatus, Aspergillus fumigatus Af293 (Q4WAW7)
Manually annotated by BRENDA team
Zou, H.; Zheng, X.; Li, S.M.
Substrate promiscuity of the cyclic dipeptide prenyltransferases from Aspergillus fumigatus
J. Nat. Prod.
72
44-52
2009
Aspergillus fumigatus (Q4WAW7), Aspergillus fumigatus Af293 (Q4WAW7)
Manually annotated by BRENDA team
Grundmann, A.; Li, S.M.
Overproduction, purification and characterization of FtmPT1, a brevianamide F prenyltransferase from Aspergillus fumigatus
Microbiology
151
2199-2207
2005
Aspergillus fumigatus (Q4WAW7), Aspergillus fumigatus, Aspergillus fumigatus Af293 (Q4WAW7)
Manually annotated by BRENDA team
Wollinsky, B.; Ludwig, L.; Xie, X.; Li, S.M.
Breaking the regioselectivity of indole prenyltransferases: identification of regular C3-prenylated hexahydropyrrolo[2,3-b]indoles as side products of the regular C2-prenyltransferase FtmPT1
Org. Biomol. Chem.
10
9262-9270
2012
Aspergillus fumigatus (Q4WAW7), Aspergillus fumigatus Af293 (Q4WAW7)
Manually annotated by BRENDA team
Chen, J.; Morita, H.; Wakimoto, T.; Mori, T.; Noguchi, H.; Abe, I.
Prenylation of a nonaromatic carbon of indolylbutenone by a fungal indole prenyltransferase
Org. Lett.
14
3080-3083
2012
Aspergillus fumigatus (Q4WAW7), Aspergillus fumigatus, Aspergillus fumigatus Af293 (Q4WAW7)
Manually annotated by BRENDA team
Mahmoodi, N.; Tanner, M.E.
Potential rearrangements in the reaction catalyzed by the indole prenyltransferase FtmPT1
ChemBioChem
14
2029-2037
2013
Aspergillus fumigatus
Manually annotated by BRENDA team
Mahmoodi, N.; Qian, Q.; Luk, L.; Tanner, M.
Rearrangements in the mechanisms of the indole alkaloid prenyltransferases
Pure Appl. Chem.
85
1935-1948
2013
Aspergillus fumigatus
-
Manually annotated by BRENDA team
Zhou, K.; Zhao, W.; Liu, X.; Li, S.
Saturation mutagenesis on Tyr205 of the cyclic dipeptide C2-prenyltransferase FtmPT1 results in mutants with strongly increased C3-prenylating activity
Appl. Microbiol. Biotechnol.
100
943-9953
2016
Aspergillus fumigatus (Q4WAW7), Aspergillus fumigatus ATCC MYA-4609 (Q4WAW7)
Manually annotated by BRENDA team
Pan, L.L.; Yang, Y.; Merz, K.M.
Origin of product selectivity in a prenyl transfer reaction from the same intermediate: exploration of multiple FtmPT1-catalyzed prenyl transfer pathways
Biochemistry
53
6126-6138
2014
Aspergillus fumigatus (Q4WAW7), Aspergillus fumigatus ATCC MYA-4609 (Q4WAW7)
Manually annotated by BRENDA team
Couillaud, J.; Rico, J.; Rubini, A.; Hamrouni, T.; Courvoisier-Dezord, E.; Petit, J.; Mariage, A.; Darii, E.; Duquesne, K.; De Berardinis, V.; Iacazio, G.
Simplified in vitro and in vivo bioaccess to prenylated compounds
ACS Omega
4
7838-7849
2019
Aspergillus fumigatus
-
Manually annotated by BRENDA team
Zhao, W.; Fan, A.; Tarcz, S.; Zhou, K.; Yin, W.B.; Liu, X.Q.; Li, S.M.
Mutation on Gly115 and Tyr205 of the cyclic dipeptide C2-prenyltransferase FtmPT1 increases its catalytic activity toward hydroxynaphthalenes
Appl. Microbiol. Biotechnol.
101
1989-1998
2017
Aspergillus fumigatus
Manually annotated by BRENDA team
Pan, L.L.; Song, L.F.; Miao, Y.; Yang, Y.; Merz, K.M.
Mechanism of formation of the nonstandard product in the prenyltransferase reaction of the G115T mutant of FtmPT1 A case of reaction dynamics calling the shots?
Biochemistry
56
2995-3007
2017
Aspergillus fumigatus (Q4WAW7)
Manually annotated by BRENDA team